The therapeutic effectiveness of ibuprofen on the symptoms of naturally acquired common colds

The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs)(1,2) and increased levels of inflammatory cytokines and mediators in nasal secretions.(3,4) We have investigated the effect of a nonsteroidal anti-inflammatory drug (N...

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Published inAmerican journal of rhinology Vol. 15; no. 4; pp. 239 - 242
Main Authors Winther, B, Mygind, N
Format Journal Article
LanguageEnglish
Published United States SAGE PUBLICATIONS, INC 01.07.2001
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Common Cold - classification
Common Cold - drug therapy
Double-Blind Method
Female
Humans
Ibuprofen - adverse effects
Ibuprofen - therapeutic use
Male
Middle Aged
Severity of Illness Index
Sneezing - drug effects
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Abstract The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs)(1,2) and increased levels of inflammatory cytokines and mediators in nasal secretions.(3,4) We have investigated the effect of a nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, 400 mg three times daily, in a placebo-controlled trial of 80 adults with naturally occurring common colds. Ibuprofen caused a significant reduction of headache (p = 0.008), earache (p = 0.01), muscle/joint pain (p = 0.045), and reduced body temperature (p = 0.02). There was a 40% reduction in the number of sneezes (p = 0.02) and a 33% reduction in the symptom score for sneezing (p = 0.04). This study did not detect any effect on other nasal symptoms.
AbstractList The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs) and increased levels of inflammatory cytokines and mediators in nasal secretions. We have investigated the effect of a nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, 400 mg three times daily, in a placebocontrolled trial of 80 adults with naturally occurring common colds. Ibuprofen caused a significant reduction of headache ( p = 0.008), earache (p = 0.01), muscle/joint pain (p = 0.045), and reduced body temperature (p = 0.02). There was a 40% reduction in the number of sneezes (p = 0.02) and a 33% reduction in the symptom score for sneezing (p = 0.04). This study did not detect any effect on other nasal symptoms. [PUBLICATION ABSTRACT]
The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs) 1,2 and increased levels of inflammatory cytokines and mediators in nasal secretions. 3,4 We have investigated the effect of a nonsteroidal anti-inflammatory drug (NSAID) ibuprofen, 400 mg three times daily, in a placebo-controlled trial of 80 adults with naturally occurring common colds. Ibuprofen caused a significant reduction of headache (p = 0.008), earache (p = 0.01), muscle/joint pain (p = 0.045), and reduced body temperature (p = 0.02). There was a 40% reduction in the number of sneezes (p = 0.02) and a 33% reduction in the symptom score for sneezing (p = 0.04). This study did not detect any effect on other nasal symptoms.
Author Mygind, N
Winther, B
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Snippet The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs)(1,2) and increased levels...
The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs) 1,2 and increased levels...
The pathogenesis of the common cold is associated with inflammation of the nasal mucous membrane with polymorphonuclear cells (PMNs) and increased levels of...
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SubjectTerms Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Common Cold - classification
Common Cold - drug therapy
Double-Blind Method
Female
Humans
Ibuprofen - adverse effects
Ibuprofen - therapeutic use
Male
Middle Aged
Severity of Illness Index
Sneezing - drug effects
Title The therapeutic effectiveness of ibuprofen on the symptoms of naturally acquired common colds
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