Age-related Changes in Bone Marrow Mesenchymal Stromal Cells A Potential Impact on Osteoporosis and Osteoarthritis Development

Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has...

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Published inCell transplantation Vol. 26; no. 9; pp. 1520 - 1529
Main Authors Ganguly, Payal, El-Jawhari, Jehan J., Giannoudis, Peter V., Burska, Agata N., Ponchel, Frederique, Jones, Elena A.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.2017
Subjects
Original
mesenchymal stromal cells (MSCs)
in vivo
aging
bone marrow (BM)
in vitro
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Abstract Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and “fitness” of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs “age” similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.
AbstractList Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and “fitness” of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs “age” similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.
Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and "fitness" of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs "age" similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and "fitness" of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs "age" similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.
Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and “fitness” of mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well recognized that MSCs in vitro acquire culture-induced aging features such as gradual telomere shortening, increased numbers of senescent cells, and reduced resistance to oxidative stress as a result of serial population doublings. In contrast, there is only limited evidence that human BM-MSCs “age” similarly in vivo . This review compares the various aspects of in vitro and in vivo MSC aging and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.
Author Ganguly, Payal
Ponchel, Frederique
El-Jawhari, Jehan J.
Giannoudis, Peter V.
Burska, Agata N.
Jones, Elena A.
AuthorAffiliation 1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
2 Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
AuthorAffiliation_xml – name: 1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
– name: 2 Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Author_xml – sequence: 1
  givenname: Payal
  surname: Ganguly
  fullname: Ganguly, Payal
– sequence: 2
  givenname: Jehan J.
  surname: El-Jawhari
  fullname: El-Jawhari, Jehan J.
– sequence: 3
  givenname: Peter V.
  surname: Giannoudis
  fullname: Giannoudis, Peter V.
– sequence: 4
  givenname: Agata N.
  surname: Burska
  fullname: Burska, Agata N.
– sequence: 5
  givenname: Frederique
  surname: Ponchel
  fullname: Ponchel, Frederique
– sequence: 6
  givenname: Elena A.
  surname: Jones
  fullname: Jones, Elena A.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29113463$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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Keywords mesenchymal stromal cells (MSCs)
in vivo
aging
bone marrow (BM)
in vitro
Language English
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crossref_primary_10_1177_0963689717721201
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PublicationDate 20170900
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PublicationDate_xml – month: 9
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PublicationTitle Cell transplantation
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Publisher SAGE Publications
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Snippet Aging at the cellular level is a complex process resulting from accumulation of various damages leading to functional impairment and a reduced quality of life...
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SubjectTerms Original
Subtitle A Potential Impact on Osteoporosis and Osteoarthritis Development
Title Age-related Changes in Bone Marrow Mesenchymal Stromal Cells
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https://www.ncbi.nlm.nih.gov/pubmed/29113463
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Volume 26
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