Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function

• Published in: Molecular biology of the cell Vol. 22; no. 9; pp. 1575 - 1584
• Main Authors: Liu, Yuan, Nakatsukasa, Kunio, Kotera, Michiko, Kanada, Akira, Nishimura, Takashi, Kishi, Tsutomu, Mimura, Satoru, Kamura, Takumi
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.05.2011
• Subjects: F-Box Proteins - metabolism; Gene Deletion; HEK293 Cells; Humans; Protein Binding; rab5 GTP-Binding Proteins - antagonists & inhibitors; rab5 GTP-Binding Proteins - metabolism; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - antagonists & inhibitors; Saccharomyces cerevisiae Proteins - metabolism; Sequence Deletion - genetics; SKP Cullin F-Box Protein Ligases - metabolism; Ubiquitin-Protein Ligases - metabolism

Skp1/Cul1/F-box (SCF)-type F-box proteins are a component of the Cullin-RING SCF ubiquitin E3 ligase, which is involved in numerous cellular processes. However, the function of non-SCF-type F-box proteins remains largely unknown. The Rab5-like small guanosine 5'-triphosphatase Vps21/Ypt51 is a...