Monitoring xenotransplant recipients for infection by PERV

• Published in: Clinical biochemistry Vol. 34; no. 1; pp. 23 - 27
• Main Authors: Herring, Chris, Cunningham, Deirdre A, Whittam, Alison J, Fernández-Suárez, Xosé M, Langford, Gillian A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2001
• Subjects: Animals; Chemistry, Clinical - methods; DNA, Viral - analysis; Humans; microchimerism; Patient monitoring; pigs; Porcine endogenous retrovirus; Retrospective Studies; Retroviridae - metabolism; Retroviridae Infections - diagnosis; Retroviridae Infections - transmission; Reverse Transcriptase Polymerase Chain Reaction; Review; Swine; Transplantation, Heterologous - adverse effects; Xenotransplantation; Xenozoonosis; Patient monitoring; Porcine endogenous retrovirus; Review; Xenozoonosis; Xenotransplantation

Objectives: Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus ( PERV) to porcine xenograft recipients. Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell...