Monitoring xenotransplant recipients for infection by PERV
Objectives: Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus ( PERV) to porcine xenograft recipients. Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell...
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| Published in | Clinical biochemistry Vol. 34; no. 1; pp. 23 - 27 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.02.2001
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| Subjects | |
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| Abstract | Objectives: Concerns have been raised over the possibility of transmission of
porcine endogenous retrovirus (
PERV) to porcine xenograft recipients.
Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared
PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission.
Results: To date no evidence of
PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism.
Conclusions: These data suggest that
PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from
PERV is warranted. |
|---|---|
| AbstractList | Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients.OBJECTIVESConcerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients.To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission.METHODSTo help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission.To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism.RESULTSTo date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism.These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted.CONCLUSIONSThese data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted. Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients. To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission. To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism. These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted. Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients. To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission. To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism. These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted. Objectives: Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus ( PERV) to porcine xenograft recipients. Methods: To help assess this risk, diagnostic assays capable of detection of an active, latent or cleared PERV infection, and the presence of pig cell microchimerism have been developed by a number of groups. Retrospective studies of patients exposed to living pig tissues have been performed using these assays to look for evidence of cross species transmission. Results: To date no evidence of PERV infection has been found in studies of humans exposed to pig tissues, despite evidence of long lived microchimerism. Conclusions: These data suggest that PERV infection has not occurred in a clinical setting. However, as infection has been seen in a small animal model further investigation of the risk from PERV is warranted. |
| Author | Cunningham, Deirdre A Fernández-Suárez, Xosé M Herring, Chris Langford, Gillian A Whittam, Alison J |
| Author_xml | – sequence: 1 givenname: Chris surname: Herring fullname: Herring, Chris email: Chris.herring@pharma.novartis.com organization: Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, Cambridge CB2 2YP UK – sequence: 2 givenname: Deirdre A surname: Cunningham fullname: Cunningham, Deirdre A organization: Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, Cambridge CB2 2YP UK – sequence: 3 givenname: Alison J surname: Whittam fullname: Whittam, Alison J organization: Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, Cambridge CB2 2YP UK – sequence: 4 givenname: Xosé M surname: Fernández-Suárez fullname: Fernández-Suárez, Xosé M organization: Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, Cambridge CB2 2YP UK – sequence: 5 givenname: Gillian A surname: Langford fullname: Langford, Gillian A organization: Porcine Endogenous Retrovirus Research Group, Imutran Ltd (A Novartis Pharma AG Co), PO Box 399, Cambridge CB2 2YP UK |
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| Keywords | Patient monitoring Porcine endogenous retrovirus Review Xenozoonosis Xenotransplantation |
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| Snippet | Objectives: Concerns have been raised over the possibility of transmission of
porcine endogenous retrovirus (
PERV) to porcine xenograft recipients.
Methods:... Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients. To help assess this... Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients. To help assess this... Concerns have been raised over the possibility of transmission of porcine endogenous retrovirus (PERV) to porcine xenograft recipients.OBJECTIVESConcerns have... |
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| SubjectTerms | Animals Chemistry, Clinical - methods DNA, Viral - analysis Humans microchimerism Patient monitoring pigs Porcine endogenous retrovirus Retrospective Studies Retroviridae - metabolism Retroviridae Infections - diagnosis Retroviridae Infections - transmission Reverse Transcriptase Polymerase Chain Reaction Review Swine Transplantation, Heterologous - adverse effects Xenotransplantation Xenozoonosis |
| Title | Monitoring xenotransplant recipients for infection by PERV |
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