Reevaluation of nucleotide sequences of wild-type and attenuated polioviruses of type 3

• Published in: Virus research Vol. 65; no. 2; pp. 111 - 119
• Main Authors: Rezapkin, Gennady V., Douthitt, Monica, Dragunsky, Eugenia, Chumakov, Konstantin M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.1999
• Subjects: Animals; Attenuation; Base Sequence; Consumer Product Safety; Macaca mulatta; Mice; Mice, Transgenic; Neurovirulence; Oral poliovirus vaccine (OPV); Poliomyelitis - genetics; Poliomyelitis - pathology; Poliovirus; Poliovirus - genetics; Poliovirus - pathogenicity; Poliovirus Vaccine, Oral - adverse effects; Poliovirus Vaccine, Oral - genetics; Vaccine safety; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - genetics; Attenuation; Vaccine safety; Neurovirulence; Oral poliovirus vaccine (OPV)

Published sequences of wild-type and attenuated Sabin strains of type 3 poliovirus (Leon/37 and Leon 12a 1b) were derived from cDNA clones. Recent direct sequencing of Sabin 3 RNA showed that it differed from the published sequence in at least two sites. Here results of direct sequencing of genomes...