Propofol attenuates the adhesion of tumor and endothelial cells through inhibiting glycolysis in human umbilical vein endothelial cells

• Published in: Acta biochimica et biophysica Sinica Vol. 51; no. 11; pp. 1114 - 1122
• Main Authors: Qi, Jie, Wu, Qichao, Zhu, Xuqin, Zhang, Shan, Chen, Xiangyuan, Chen, Wankun, Sun, Zhirong, Zhu, Minmin, Miao, Changhong
• Format: Journal Article
• Language: English
• Published: China China Science Publishing & Media Ltd 18.11.2019
• Subjects: Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; CaMKII; Carcinoma, Hepatocellular - drug therapy; Cell Adhesion - drug effects; Cell Adhesion Molecules - metabolism; Cells, Cultured; glycolysis; Glycolysis - drug effects; HIF-1α; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - pathology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver Neoplasms - drug therapy; propofol; Propofol - pharmacology; tumor endothelial cell; tumor endothelial cell; HIF-1α; CaMKII; propofol; glycolysis

Propofol is one of the most commonly used intravenous anesthetics and plays an important role in tumor suppression. In the present study, we aimed to investigate the mechanism by which propofol attenuates tumor endothelial cells (TECs) and tumor cell adhesion to inhibit tumor metastasis in vitro. Hu...