Molecular Mechanisms Underlying the Divergent Roles of SPARC in Human Carcinogenesis

• Published in: Carcinogenesis (New York) Vol. 35; no. 5; pp. 967 - 973
• Main Authors: Nagaraju, Ganji Purnachandra, Dontula, Ranadheer, Bassel, El-Rayes F., Lakka, Sajani S
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2014
• Subjects: Animals; Apoptosis - genetics; Carcinogenesis - genetics; Carcinogenesis - metabolism; Cell Adhesion - genetics; Cell Movement - genetics; Cell Survival - genetics; Disease Progression; Extracellular Matrix - metabolism; Humans; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Osteonectin - genetics; Osteonectin - metabolism

Communication between the cell and its surrounding environment, consisting of proteinaceous (non-living material) and extracellular matrix (ECM), is important for bio-physiological and chemical signaling. This signaling results in a range of cellular activities, including cell division, adhesion, di...