Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model

• Published in: Pharmaceutical research Vol. 23; no. 8; pp. 1675 - 1686
• Main Authors: Cao, Xianhua, Gibbs, Seth T., Fang, Lanyan, Miller, Heather A., Landowski, Christopher P., Shin, Ho-Chul, Lennernas, Hans, Zhong, Yanqiang, Amidon, Gordon L., Yu, Lawrence X., Sun, Duxin
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01.08.2006; Springer Nature B.V
• Subjects: Animals; Bioavailability; Biological and medical sciences; Biological Availability; Carrier Proteins - genetics; Carrier Proteins - metabolism; Chromatography, High Pressure Liquid; Colon - metabolism; Correlation analysis; Data Interpretation, Statistical; drug transporter; Duodenum - metabolism; FARMACI; Gene expression; General pharmacology; Human subjects; Humans; inter-species correlation; Intestinal Absorption - physiology; intestinal permeability; Large intestine; Medical sciences; metabolizing enzyme; Oligonucleotide Array Sequence Analysis; oral bioavailability; Perfusion; Permeability; Pharmaceutical Preparations - metabolism; Pharmaceutical technology. Pharmaceutical industry; Pharmacology; Pharmacology. Drug treatments; PHARMACY; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; RNA - biosynthesis; RNA - isolation & purification; RNA, Complementary - biosynthesis; RNA, Complementary - genetics; Rodents; Small intestine; Species Specificity; Correlation; Rat; drug transporter; intestinal permeability; Absorption; oral bioavailability; Species; Carrier protein; Human; Drug; metabolizing enzyme; Pharmaceutical technology; Enzyme; Rodentia; Gut; Oral administration; Bioavailability; Permeability; Gene expression; Vertebrata; Mammalia; Animal; Drug-metabolizing enzyme; inter-species correlation; Pharmacokinetics

To study the correlation of intestinal absorption for drugs with various absorption routes between human and rat, and to explore the underlying molecular mechanisms for the similarity in drug intestinal absorption and the differences in oral bioavailability between human and rat. The intestinal perm...