Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model - Cao, Xianhua; Gibbs, Seth T.; Fang, Lanyan; Miller, Heather A.; Landowski, Christopher P.; Shin, Ho-Chul; Lennernas, Hans; Zhong, Yanqiang; Amidon, Gordon L.; Yu, Lawrence X.; Sun, Duxin (Pharmaceutical research, 2006)
Keywords: Animals; Bioavailability; Biological and medical sciences; Biological Availability; Carrier Proteins - genetics; Carrier Proteins - metabolism; Chromatography, High Pressure Liquid; Colon - metabolism; Correlation analysis; Data Interpretation, Statistical; drug transporter; Duodenum - metabolism; FARMACI; Gene expression; General pharmacology; Human subjects; Humans; inter-species correlation; Intestinal Absorption - physiology; intestinal permeability; Large intestine; Medical sciences; metabolizing enzyme; Oligonucleotide Array Sequence Analysis; oral bioavailability; Perfusion; Permeability; Pharmaceutical Preparations - metabolism; Pharmaceutical technology. Pharmaceutical industry; Pharmacology; Pharmacology. Drug treatments; PHARMACY; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; RNA - biosynthesis; RNA - isolation & purification; RNA, Complementary - biosynthesis; RNA, Complementary - genetics; Rodents; Small intestine; Species Specificity; Correlation; Rat; drug transporter; intestinal permeability; Absorption; oral bioavailability; Species; Carrier protein; Human; Drug; metabolizing enzyme; Pharmaceutical technology; Enzyme; Rodentia; Gut; Oral administration; Bioavailability; Permeability; Gene expression; Vertebrata; Mammalia; Animal; Drug-metabolizing enzyme; inter-species correlation; Pharmacokinetics