Controlling the efficiency of excision repair

• Published in: Mutation research Vol. 485; no. 1; pp. 3 - 13
• Main Author: Hanawalt, Philip C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.02.2001
• Subjects: 5-bromouracil; Animals; Apoptosis; Cancer; Cockayne syndrome; cyclobutane pyrimidine dimers; DNA - biosynthesis; DNA - history; DNA - radiation effects; DNA Damage; DNA Repair; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli - radiation effects; Genomic instability; global genomic nucleotide excision repair; Global genomic repair; History, 20th Century; Humans; Li-Fraumeni syndrome; p53; SOS response; Transcription coupled repair; Transcription, Genetic; Ultraviolet light; Ultraviolet Rays; United States; Xeroderma pigmentosum; United States; Transcription coupled repair; Cockayne syndrome; Ultraviolet light; Global genomic repair; Xeroderma pigmentosum; SOS response; DNA repair; Genomic instability; p53; Li-Fraumeni syndrome; Cancer; Apoptosis

The early studies are recounted, that led to the discovery of the ubiquitous process of DNA excision repair, followed by a review of the pathways of transcription-coupled repair (TCR) and global genomic nucleotide excision repair (GGR). Repair replication of damaged DNA in UV-irradiated bacteria was...