Golgi α-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals

• Published in: BBA - General Subjects Vol. 1573; no. 3; pp. 225 - 235
• Main Author: Moremen, Kelley W
• Format: Book Review Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 19.12.2002
• Subjects: Anemia, Dyserythropoietic, Congenital; animal physiology; Animals; antagonists & inhibitors; Asparagine; Asparagine - metabolism; Carbohydrates; Carbohydrates - physiology; deficiency; Disease Models, Animal; enzymology; Golgi Apparatus; Golgi Apparatus - enzymology; Golgi mannosidase II; Humans; Mammal; Mammals; Mannosidases; Mannosidases - antagonists & inhibitors; Mannosidases - deficiency; Mannosidases - metabolism; metabolism; Mice; Oligosaccharide; Oligosaccharides; Oligosaccharides - metabolism; physiology; Vertebrates; E-PHA; IL; Golgi mannosidase II; Oligosaccharide; CDG; CHO; ER; SCID; TNF; Mammal; pNP; GlcNAc; Man; HEMPAS

The maturation of N-glycans to complex type structures on cellular and secreted proteins is essential for the roles that these structures play in cell adhesion and recognition events in metazoan organisms. Critical steps in the biosynthetic pathway leading from high mannose to complex structures inc...