Copper subtype of Alzheimer's disease (AD): Meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD

• Published in: Journal of trace elements in medicine and biology Vol. 28; no. 4; pp. 482 - 485
• Main Author: Squitti, Rosanna
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.10.2014
• Subjects: Adenosine Triphosphatases - metabolism; Alzheimer Disease - blood; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; ATP7B; Cation Transport Proteins - metabolism; Ceruloplasmin; Ceruloplasmin - metabolism; Cognitive Dysfunction - blood; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Copper; Copper - blood; Copper-transporting ATPases; Humans; Non-Cp copper; Ceruloplasmin; Non-Cp copper; ATP7B; Copper; Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia. A myriad of complex factors contribute to AD, promoting the deposition in plaques of amyloid-beta (Aβ), which is the main constituent of this pathognomonic sign of AD at autopsy brain inspection. Aβ toxicity is related to oxidative s...