Action of green tea catechin on bone metabolic disorder in chronic cadmium-poisoned rats

• Published in: Life sciences (1973) Vol. 73; no. 12; pp. 1479 - 1489
• Main Authors: Choi, Jeong-Hwa, Rhee, In-Koo, Park, Keun-Yong, Park, Kun-Young, Kim, Jong-Ki, Rhee, Soon-Jae
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 08.08.2003
• Subjects: Amino Acids - urine; Animals; Bone and Bones - drug effects; Bone Density - drug effects; Bone Diseases, Metabolic - chemically induced; Bone Diseases, Metabolic - metabolism; Bone mineral density; Bone Resorption - chemically induced; Bone Resorption - metabolism; Cadmium; Cadmium Poisoning - metabolism; Calcium - metabolism; Catechin; Catechin - administration & dosage; Chronic Disease; Creatinine - urine; Deoxypyridinoline; Dose-Response Relationship, Drug; Male; Osteocalcin; Osteocalcin - blood; Rats; Rats, Sprague-Dawley; Tea - chemistry; Deoxypyridinoline; Cadmium; Osteocalcin; Catechin; Bone mineral density
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/S0024-3205(03)00433-8

The purpose of this study was to investigate the effects of green tea catechin on bone metabolic disorders and its mechanism in chronic cadmium-poisoned rats. Sprague-Dawley male rats weighing 100 ± 10 g were randomly assigned to one control group and three cadmium-poisoned groups. The cadmium groups included a catechin free diet (Cd-0C) group, a 0.25% catechin diet (Cd-0.25C) group and a 0.5% catechin diet (Cd-0.5C) group according to their respective levels of catechin supplement. After 20 weeks, the deoxypyridinoline and crosslink values measured in urine were significantly increased in the Cd-0C group. Cadmium intoxication seemed to lead to an increase in bone resorption. In the catechin supplemented group (Cd-0.5C group), these urinary bone resorption marks, were decreased. The serum osteocalcin content in the cadmium-poisoned group was significantly increased as compared with the control group. In the catechin supplemented group serum osteocalcin content values were lower than the control group. The cadmium-intoxicated group (Cd-0C group), had lower bone mineral density than the control group (total body, vertebra, pelvis, tibia and femur). The catechin supplement increased bone mineral density to about the same as the control group. Bone mineral content showed a similar trend to total bone mineral density. Therefore, the bone mineral content of the Cd-0C group at the 20th week was significantly lower than the control group. The catechin supplemented group (Cd-0.5C group) was about the same as the control group. The cause of decreasing bone mineral density and bone mineral content by cadmium poisoning was due to the fast bone turnover rate, where bone resorption occurred at a higher rate than bone formation. The green tea catechin aided in normalizing bone metabolic disorders in bone mineral density, bone mineral content and bone calcium content caused by chronic cadmium intoxication.