Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies
Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food consumption (FC) rather than toxicity. When offered a choice, rats preferred basal diet to diet with relatively low concentrations of neotame. When...
Saved in:
Published in | Regulatory toxicology and pharmacology Vol. 38; no. 2; pp. 124 - 143 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
01.10.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food consumption (FC) rather than toxicity. When offered a choice, rats preferred basal diet to diet with relatively low concentrations of neotame. When no choice was available, rats ate less as concentrations increased, demonstrating reduced palatability. Changes in dietary concentrations of neotame resulted in changes in FC. The maximum tolerable doses (MTDs) in rats, dogs, and mice were due to decreases in BWG secondary to poor palatability of diets when neotame concentrations exceeded approximately 35,000
ppm. Concentrations were increased as animals grew to maintain constant dosing on a “mg/kg bw/day” basis. Food conversion efficiency (FCE) was not changed in rats during periods of active growth. The only consistent findings across safety studies were reductions in BW, BWG, and FC with no dose–response in rats, mice, and dogs. In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings. Analysis of data from long-term studies in Sprague–Dawley rats support the conclusion that changes in FC alone can cause the observed changes in BWG in neotame studies when changes are scaled allometrically [Regul. Toxicol. Pharmacol. (2003)]. Consequently, BW parameters are not appropriate endpoints for setting no-observed-effect levels (NOELs) for neotame. |
---|---|
AbstractList | Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food consumption (FC) rather than toxicity. When offered a choice, rats preferred basal diet to diet with relatively low concentrations of neotame. When no choice was available, rats ate less as concentrations increased, demonstrating reduced palatability. Changes in dietary concentrations of neotame resulted in changes in FC. The maximum tolerable doses (MTDs) in rats, dogs, and mice were due to decreases in BWG secondary to poor palatability of diets when neotame concentrations exceeded approximately 35,000 ppm. Concentrations were increased as animals grew to maintain constant dosing on a "mg/kg bw/day" basis. Food conversion efficiency (FCE) was not changed in rats during periods of active growth. The only consistent findings across safety studies were reductions in BW, BWG, and FC with no dose-response in rats, mice, and dogs. In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings. Analysis of data from long-term studies in Sprague-Dawley rats support the conclusion that changes in FC alone can cause the observed changes in BWG in neotame studies when changes are scaled allometrically [Regul. Toxicol. Pharmacol. (2003)]. Consequently, BW parameters are not appropriate endpoints for setting no-observed-effect levels (NOELs) for neotame. Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food consumption (FC) rather than toxicity. When offered a choice, rats preferred basal diet to diet with relatively low concentrations of neotame. When no choice was available, rats ate less as concentrations increased, demonstrating reduced palatability. Changes in dietary concentrations of neotame resulted in changes in FC. The maximum tolerable doses (MTDs) in rats, dogs, and mice were due to decreases in BWG secondary to poor palatability of diets when neotame concentrations exceeded approximately 35,000ppm. Concentrations were increased as animals grew to maintain constant dosing on a 'mg/kg bw/day' basis. Food conversion efficiency (FCE) was not changed in rats during periods of active growth. The only consistent findings across safety studies were reductions in BW, BWG, and FC with no dose-response in rats, mice, and dogs. In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings. Analysis of data from long-term studies in Sprague-Dawley rats support the conclusion that changes in FC alone can cause the observed changes in BWG in neotame studies when changes are scaled allometrically [Regul. Toxicol. Pharmacol. (2003)]. Consequently, BW parameters are not appropriate endpoints for setting no-observed-effect levels (NOELs) for neotame. Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food consumption (FC) rather than toxicity. When offered a choice, rats preferred basal diet to diet with relatively low concentrations of neotame. When no choice was available, rats ate less as concentrations increased, demonstrating reduced palatability. Changes in dietary concentrations of neotame resulted in changes in FC. The maximum tolerable doses (MTDs) in rats, dogs, and mice were due to decreases in BWG secondary to poor palatability of diets when neotame concentrations exceeded approximately 35,000 ppm. Concentrations were increased as animals grew to maintain constant dosing on a “mg/kg bw/day” basis. Food conversion efficiency (FCE) was not changed in rats during periods of active growth. The only consistent findings across safety studies were reductions in BW, BWG, and FC with no dose–response in rats, mice, and dogs. In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings. Analysis of data from long-term studies in Sprague–Dawley rats support the conclusion that changes in FC alone can cause the observed changes in BWG in neotame studies when changes are scaled allometrically [Regul. Toxicol. Pharmacol. (2003)]. Consequently, BW parameters are not appropriate endpoints for setting no-observed-effect levels (NOELs) for neotame. |
Author | Mayhew, Dale A. Wayne Stargel, W. Phil Comer, C. |
Author_xml | – sequence: 1 givenname: Dale A. surname: Mayhew fullname: Mayhew, Dale A. email: dale.a.mayhew@nutrasweet.com organization: Regulatory Affairs, The NutraSweet Company, 1801 Maple Street, Evanston, IL 60201, USA – sequence: 2 givenname: C. surname: Phil Comer fullname: Phil Comer, C. organization: Graystone Associates, Inc., P.O. Box 6598, Macon, GA31208, USA – sequence: 3 givenname: W. surname: Wayne Stargel fullname: Wayne Stargel, W. organization: Research and Development, The NutraSweet Company, Evanston, IL, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14550755$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkc-OFCEQxolZ486uPoKGk3ETW2lo-s9ejNm4arKJB_VMqqGYwXTDCLTjvNI-pczORI-eoKp-VR_Fd0HOfPBIyPOavalZ3b79yngnKi4Ye8XEFWOsa6r2EVnVbGgrxgd5RlZ_kXNykdKPAvG-756Q87qRknVSrsj9bQiG6uDTMm-zC56CN3QMZk936NabTPUG_BoT3bm8oR5DhhlfUyjXHU07xIwe47HqfAkS0gwp4zU1zlqM6LOD7PyaYgl1TjRYuoUJMoxucnlPbQwzzeG304fI-dKIGeKeJrBYMikvJZOekscWpoTPTucl-X774dvNp-ruy8fPN-_vKi0Gnqu-Ay2labCWvZFy5JzbTksxyNb0o7CiZwhygK7tobO2F43QfanzhsFgoRWX5OVx7jaGnwumrGaXNE4TlO2XpOqBMy7roYDyCOoYUopo1Ta6uTxc1UwdTFIPJqmDA4oJ9WCSOgi8OAks44zmX9fJlQK8OwJY1vzlMKqkHXqNxsXyg8oE9x-JPyRCpx0 |
CitedBy_id | crossref_primary_10_1080_00032719_2014_924008 crossref_primary_10_2903_j_efsa_2007_581 crossref_primary_10_1016_j_fct_2015_12_024 crossref_primary_10_2903_j_efsa_2013_3301 crossref_primary_10_3390_molecules23102454 crossref_primary_10_1177_216507990805600604 crossref_primary_10_1016_j_fct_2017_06_046 crossref_primary_10_1007_s10068_024_01597_x crossref_primary_10_1016_j_fct_2015_12_022 crossref_primary_10_2174_1573399818666220429083052 crossref_primary_10_1111_ijfs_12123 crossref_primary_10_1214_09_STS301 crossref_primary_10_3390_molecules23020367 crossref_primary_10_1016_j_fct_2017_05_047 crossref_primary_10_1016_j_fct_2008_05_003 crossref_primary_10_1111_j_1541_4337_2006_tb00081_x crossref_primary_10_4236_health_2018_105054 crossref_primary_10_1016_j_fct_2008_04_042 crossref_primary_10_1080_10408398_2021_1895057 crossref_primary_10_3928_08910162_20080601_02 crossref_primary_10_1016_j_anifeedsci_2016_02_013 crossref_primary_10_15237_gida_GD20070 crossref_primary_10_1016_j_fct_2011_09_004 crossref_primary_10_1016_j_yrtph_2004_01_001 crossref_primary_10_1016_j_fct_2015_11_014 crossref_primary_10_1016_j_fct_2021_112236 |
Cites_doi | 10.1016/0031-9384(78)90220-2 10.1037/h0077474 10.1093/chemse/20.5.573 10.1016/0300-483X(77)90037-3 10.1006/appe.2001.0467 10.1016/S0940-2993(97)80135-2 10.1016/0041-008X(79)90066-8 10.1093/chemse/13.3.397 10.1177/019262339602400620 10.1016/0278-6915(85)90142-5 10.1016/S0278-6915(00)00023-5 10.1098/rspb.1950.0065 10.1159/000177589 10.1139/y86-167 10.1177/019262339402200308 10.1038/bjc.1974.45 10.1152/ajplegacy.1947.151.1.110 10.1016/0031-9384(78)90262-7 10.2307/2528490 10.1016/0031-9384(86)90228-3 10.1093/geronj/32.1.49 10.1093/toxsci/58.1.195 10.1007/BF03353422 10.1016/S0273-2300(03)00075-8 10.1093/jn/132.1.101 10.1093/jn/102.11.1477 10.1037/0097-7403.25.1.28 10.1038/bjc.1979.68 10.1016/0149-7634(84)90041-1 10.3109/01480549809017854 |
ContentType | Journal Article |
Copyright | 2003 Elsevier Inc. |
Copyright_xml | – notice: 2003 Elsevier Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U7 C1K |
DOI | 10.1016/S0273-2300(03)00074-6 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Toxicology Abstracts Environmental Sciences and Pollution Management |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Toxicology Abstracts Environmental Sciences and Pollution Management |
DatabaseTitleList | MEDLINE Toxicology Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1096-0295 |
EndPage | 143 |
ExternalDocumentID | 10_1016_S0273_2300_03_00074_6 14550755 S0273230003000746 |
Genre | Journal Article Comparative Study |
GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29P 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATCM AAXUO ABEFU ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFS ACRLP ADBBV ADEZE ADFGL ADMUD AEBSH AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC C45 CAG COF CS3 DM4 DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F3I F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMT HVGLF HZ~ IHE J1W KCYFY KOM LG5 M33 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SPT SSJ SSP SSZ T5K TEORI UHS WUQ XPP ZGI ZMT ZU3 ZXP ~G- ~KM AAHBH AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7U7 C1K |
ID | FETCH-LOGICAL-c392t-87ac55d4e158d55b222f7c53956d8b3f380ea59a768a7ff8343c8c53240a9fa63 |
IEDL.DBID | AIKHN |
ISSN | 0273-2300 |
IngestDate | Fri Aug 16 05:16:32 EDT 2024 Thu Sep 26 16:46:53 EDT 2024 Sat Sep 28 07:49:25 EDT 2024 Fri Feb 23 02:17:14 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | Sprague–Dawley Palatability Rat Preference Neotame Food consumption Sweeteners Dog Allometric growth |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c392t-87ac55d4e158d55b222f7c53956d8b3f380ea59a768a7ff8343c8c53240a9fa63 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
PMID | 14550755 |
PQID | 19202519 |
PQPubID | 23462 |
PageCount | 20 |
ParticipantIDs | proquest_miscellaneous_19202519 crossref_primary_10_1016_S0273_2300_03_00074_6 pubmed_primary_14550755 elsevier_sciencedirect_doi_10_1016_S0273_2300_03_00074_6 |
PublicationCentury | 2000 |
PublicationDate | 2003-10-01 |
PublicationDateYYYYMMDD | 2003-10-01 |
PublicationDate_xml | – month: 10 year: 2003 text: 2003-10-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Regulatory toxicology and pharmacology |
PublicationTitleAlternate | Regul Toxicol Pharmacol |
PublicationYear | 2003 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Thomford, P., Carter, J., 1997b. 52-Week Dietary Toxicity Study of NC-00723 in Dogs Followed by a 4-Week Reversibility Period. Study Number (PCR 1017). Unpublished Report from Covance Laboratories Inc., Madison, WI Sclafani, Abrams (BIB49) 1986; 37 Peto (BIB45) 1974; 29 Smith, Sclafani (BIB50) 2002; 38 Willoughby, C., 1997. NC-00723: Two Generation Reproductive Study by Dietary Administration to CD Rats. Study Number (PCR 1001). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK FDA, 2002. Food additives permitted for direct addition to food for human consumption; neotame. Fed. Regist. 67 (131), 45300–45310 Keenan, Laroque, Ballam, Soper, Dixit, Mattson, Adams, Coleman (BIB27) 1996; 24 Peck (BIB44) 1978; 92 Dunnett (BIB8) 1964; 20 Flamm, W.G., Blackburn, G.L., Comer, C.P., Mayhew, D.A., Stargel, W.W., 2003. Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions. Regul. Toxicol. Pharmacol. 38 Schoenig, Goldenthal, Geil, Frith, Richter, Carlborg (BIB48) 1985; 23 Thomsen, Dalton, Stewart (BIB54) 1988; 13 Nofre, Tinti (BIB41) 1991 Jakubczak (BIB24) 1977; 32 Ferrell (BIB10) 1984; 8 Kratz, Levitsky, Lustick (BIB30) 1978; 20 Ackroff, Sclafani (BIB1) 1999; 25 Mitchell, D., Brown, M., 1997a. NC-00723: 52-Week Toxicity Study by Dietary Administration to CD Rats with Exposure In Utero and Followed by a 4-Week Reversibility Period. Study Number (PCR 1011). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK FDA, 1982. Toxicological principles for the safety assessment of direct food additives and color additives used in food: “Redbook.” Washington, DC FDA, 1998a. Food additives permitted for direct addition to food for human consumption; sucralose. Fed. Regist. 63 (64), 16417–16433 Flamm, G., 2002. A proposed policy for assessing palatability issues based on lessons learned. Toxicology Forum symposium, Aspen, Colorado, USA, July 8, 2002. Toxicology Forum Proceedings, Summer Meeting, 2002 Pizzi, Holson, Merkel, Gough (BIB46) 1986; 12 Adolph (BIB2) 1947; 151 Oishi, Oishi, Hiraga (BIB43) 1979; 47 ANZFA, 2001. Inquiry Report and Regulatory Impact Statement, Permission for Use of Neotame, Australia New Zealand Food Authority (ANZFA) 30 May, 2001, p. 9 Duffy, Lewis, Mayhugh, McCracken, Thom, Reeves, Blakely, Casciano, Feuers (BIB7) 2002; 132 Levene (BIB33) 1960 WHO, 1983. Evaluation of certain food additives and contaminants. Acesulfame Potassium. 27th Report of the Joint/WHO/FAO Expert Committee on Food Additives (JECFA), World Health Organization (WHO) Technical Report Series No. 696 Nicholls, I., 1997a. NC-00723: Dietary Preference Study. Study Number (PCR 1150). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK Chowaniec, Hicks (BIB4) 1979; 39 Kennedy (BIB28) 1950; 137 FDA , 1999a. Food additives permitted for direct addition to food for human consumption; sucralose. Fed. Regist. 64 (155), 43908–43909 Schärer (BIB47) 1977; 7 Glaser, Tinti, Nofre (BIB21) 1995; 20 Jakubczak (BIB25) 1978; 20 Christian, Hoberman, Johnson, Brown, Bucci (BIB5) 1998; 21 Keenan, Smith, Hertzog, Soper, Ballam, Clark (BIB26) 1994; 22 Nicholls, I., 1997b. NC-00723: Dietary Preference Feasibility Study. Study Number (PCR 1132). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK Grice, Goldsmith (BIB22) 2000; 38 Thomford, P., Carter, J., 1997a. 104-Week Dietary Carcinogenicity Study with NC-00723 in CD-1 Mice. Study Number (PCR 1014). Unpublished Report from Covance Laboratories Inc., Madison, WI Kennedy (BIB29) 1967; vol. 1 Mitchell, D., Brown, M., 1995. NC-00723: Toxicity Study by Dietary Administration to CD Rats for 13-Weeks Followed by a 4-Week Reversibility Period. Study Number (PCR 0988). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK Eaton, Klaassen (BIB9) 2001 Nolen (BIB42) 1972; 102 Macdonald (BIB34) 1990; 34 Duffy, Seng, Lewis, Mayhugh, Aidoo, Hattan, Casiciano, Feuers (BIB6) 2001; 13 FDA, 1988. Food additives permitted for direct addition to food for human consumption; acesulfame potassium. Fed. Regist. 53 (145), 20379–26383 WHO, 2003. Summary and conclusions, food additives evaluated toxicologically (JECFA/61/SC). Joint FAO/WHO Expert Committee on Food Additives (JECFA), Sixty-first meeting, Rome, 10–19 June 2003. (Toxicological monograph to be published in WHO Food Additives Series No. 52.) LeBlanc, Lupin, Diamond, Macari, Richard (BIB32) 1986; 64 Winer (BIB59) 1971 FDA, 1999b. Monsanto Co.: Filing a food additive petition. Fed. Regist. 64 (25), 6100. Study reports available by Freedom of Information (FOI) request from US FDA Laroque, Keenan, Soper, Dorian, Gerin, Hoe, Duprat (BIB31) 1997; 49 Thomford, P., Saunders, W., 1995. 13-Week Dietary Toxicity Study of NC-00723 in Dogs Followed by a 4-Week Reversibility Period. Study Number (PCR 0990). Unpublished Report from Hazleton Wisconsin Inc., Madison, WI WHO, 1991. Evaluation of certain food additives and contaminants. Trichlorogalactosucrose. WHO Food Additive Series 28. TRS 806, pp. 219–228 FDA, 1993. Toxicological principles for the safety assessment of direct food additives and color additives used in food: “Redbook II.” Washington, DC Hubert, Laroque, Gillet, Keenan (BIB23) 2000; 58 Mitchell, D., Brown, M., 1997b. NC-00723: Oncogenicity Study by Dietary Administration to CD Rats with Exposure In Utero. Study Number (PCR 1000). Unpublished Report from Huntingdon Life Sciences Ltd., Eye, Suffolk, England, UK FDA, 1998b. Monsanto Co.: Filing a food additive petition. Fed. Regist. 63 (27), 6762. Study reports available by Freedom of Information (FOI) request from US FDA Mantel (BIB35) 1966; 50 Ferrell (10.1016/S0273-2300(03)00074-6_BIB10) 1984; 8 10.1016/S0273-2300(03)00074-6_BIB18 10.1016/S0273-2300(03)00074-6_BIB19 Thomsen (10.1016/S0273-2300(03)00074-6_BIB54) 1988; 13 10.1016/S0273-2300(03)00074-6_BIB16 10.1016/S0273-2300(03)00074-6_BIB17 Keenan (10.1016/S0273-2300(03)00074-6_BIB27) 1996; 24 Hubert (10.1016/S0273-2300(03)00074-6_BIB23) 2000; 58 10.1016/S0273-2300(03)00074-6_BIB20 Grice (10.1016/S0273-2300(03)00074-6_BIB22) 2000; 38 Pizzi (10.1016/S0273-2300(03)00074-6_BIB46) 1986; 12 Jakubczak (10.1016/S0273-2300(03)00074-6_BIB25) 1978; 20 Mantel (10.1016/S0273-2300(03)00074-6_BIB35) 1966; 50 Kennedy (10.1016/S0273-2300(03)00074-6_BIB28) 1950; 137 Smith (10.1016/S0273-2300(03)00074-6_BIB50) 2002; 38 10.1016/S0273-2300(03)00074-6_BIB36 Nofre (10.1016/S0273-2300(03)00074-6_BIB41) 1991 10.1016/S0273-2300(03)00074-6_BIB37 Sclafani (10.1016/S0273-2300(03)00074-6_BIB49) 1986; 37 LeBlanc (10.1016/S0273-2300(03)00074-6_BIB32) 1986; 64 Laroque (10.1016/S0273-2300(03)00074-6_BIB31) 1997; 49 Christian (10.1016/S0273-2300(03)00074-6_BIB5) 1998; 21 Duffy (10.1016/S0273-2300(03)00074-6_BIB6) 2001; 13 Keenan (10.1016/S0273-2300(03)00074-6_BIB26) 1994; 22 Peck (10.1016/S0273-2300(03)00074-6_BIB44) 1978; 92 10.1016/S0273-2300(03)00074-6_BIB38 10.1016/S0273-2300(03)00074-6_BIB39 Ackroff (10.1016/S0273-2300(03)00074-6_BIB1) 1999; 25 Adolph (10.1016/S0273-2300(03)00074-6_BIB2) 1947; 151 Duffy (10.1016/S0273-2300(03)00074-6_BIB7) 2002; 132 Levene (10.1016/S0273-2300(03)00074-6_BIB33) 1960 10.1016/S0273-2300(03)00074-6_BIB3 10.1016/S0273-2300(03)00074-6_BIB40 Schoenig (10.1016/S0273-2300(03)00074-6_BIB48) 1985; 23 Macdonald (10.1016/S0273-2300(03)00074-6_BIB34) 1990; 34 Nolen (10.1016/S0273-2300(03)00074-6_BIB42) 1972; 102 Eaton (10.1016/S0273-2300(03)00074-6_BIB9) 2001 Peto (10.1016/S0273-2300(03)00074-6_BIB45) 1974; 29 Jakubczak (10.1016/S0273-2300(03)00074-6_BIB24) 1977; 32 Dunnett (10.1016/S0273-2300(03)00074-6_BIB8) 1964; 20 Kratz (10.1016/S0273-2300(03)00074-6_BIB30) 1978; 20 Kennedy (10.1016/S0273-2300(03)00074-6_BIB29) 1967; vol. 1 Winer (10.1016/S0273-2300(03)00074-6_BIB59) 1971 10.1016/S0273-2300(03)00074-6_BIB14 Oishi (10.1016/S0273-2300(03)00074-6_BIB43) 1979; 47 10.1016/S0273-2300(03)00074-6_BIB58 10.1016/S0273-2300(03)00074-6_BIB15 10.1016/S0273-2300(03)00074-6_BIB12 10.1016/S0273-2300(03)00074-6_BIB56 10.1016/S0273-2300(03)00074-6_BIB13 10.1016/S0273-2300(03)00074-6_BIB57 10.1016/S0273-2300(03)00074-6_BIB11 10.1016/S0273-2300(03)00074-6_BIB55 10.1016/S0273-2300(03)00074-6_BIB52 Chowaniec (10.1016/S0273-2300(03)00074-6_BIB4) 1979; 39 10.1016/S0273-2300(03)00074-6_BIB53 Schärer (10.1016/S0273-2300(03)00074-6_BIB47) 1977; 7 10.1016/S0273-2300(03)00074-6_BIB51 Glaser (10.1016/S0273-2300(03)00074-6_BIB21) 1995; 20 |
References_xml | – volume: 20 start-page: 665 year: 1978 end-page: 667 ident: BIB30 article-title: Differential effects of quinine and sucrose octa acetate on food intake in the rat publication-title: Physiol. Behav. contributor: fullname: Lustick – volume: 50 start-page: 163 year: 1966 end-page: 170 ident: BIB35 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration publication-title: Cancer Chemother. Rep. contributor: fullname: Mantel – volume: 34 start-page: 213 year: 1990 end-page: 215 ident: BIB34 article-title: Non-linear relationship between reduced energy intake and rate of weight loss in rats publication-title: Ann. Nutr. Metab. contributor: fullname: Macdonald – volume: 38 start-page: S1 year: 2000 end-page: S6 ident: BIB22 article-title: Sucralose—an overview of the toxicity data publication-title: Food Chem. Toxicol. contributor: fullname: Goldsmith – volume: 132 start-page: 101 year: 2002 end-page: 107 ident: BIB7 article-title: Effect of the AIN-93M purified diet and dietary restriction on survival in Sprague–Dawley rats: implications for chronic studies publication-title: J. Nutr. contributor: fullname: Feuers – volume: 29 start-page: 101 year: 1974 end-page: 105 ident: BIB45 article-title: Editorial: guidelines on the analysis of tumour rates and death rates in experimental animals publication-title: Br. J. Cancer contributor: fullname: Peto – volume: 58 start-page: 195 year: 2000 end-page: 207 ident: BIB23 article-title: The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague–Dawley rats publication-title: Toxicol. Sci. contributor: fullname: Keenan – volume: 8 start-page: 199 year: 1984 end-page: 203 ident: BIB10 article-title: Preference for sugars and nonnutritive sweeteners in young beagles publication-title: Neurosci. Biobehav. Rev. contributor: fullname: Ferrell – volume: 25 start-page: 28 year: 1999 end-page: 36 ident: BIB1 article-title: Palatability and foraging cost interact to control caloric intake publication-title: J. Exp. Psychol.: Anim. Behav. contributor: fullname: Sclafani – volume: 37 start-page: 253 year: 1986 end-page: 256 ident: BIB49 article-title: Rats show only a weak preference for the artificial sweetener aspartame publication-title: Physiol. Behav. contributor: fullname: Abrams – volume: 20 start-page: 482 year: 1964 end-page: 491 ident: BIB8 article-title: New tables for multiple comparisons with a control publication-title: Biometrics contributor: fullname: Dunnett – start-page: 205 year: 1991 end-page: 236 ident: BIB41 article-title: In quest of hyperpotent sweeteners publication-title: Sweet-Taste Chemoreception contributor: fullname: Tinti – start-page: 16 year: 2001 end-page: 17 ident: BIB9 publication-title: Casarett & Doull’s Toxicology contributor: fullname: Klaassen – volume: 22 start-page: 300 year: 1994 end-page: 315 ident: BIB26 article-title: The effects of overfeeding and dietary restriction on Sprague–Dawley rat survival and early pathology biomarkers of aging publication-title: Toxicol. Pathol. contributor: fullname: Clark – volume: 13 start-page: 263 year: 2001 end-page: 272 ident: BIB6 article-title: The effects of different levels of dietary restriction on aging and survival in the Sprague–Dawley rat: implications for chronic studies publication-title: Aging Clin. Exp. Res. contributor: fullname: Feuers – volume: 151 start-page: 110 year: 1947 end-page: 125 ident: BIB2 article-title: Urges to eat and drink in rats publication-title: Am. J. Physiol. contributor: fullname: Adolph – volume: 12 start-page: 1298 year: 1986 ident: BIB46 article-title: A study of taste preferences and polydipsic drinking elicited by saccharin but not aspartame in rat, mouse, and hamster publication-title: Soc. Neurosci. Abstr. contributor: fullname: Gough – volume: 21 start-page: 97 year: 1998 end-page: 117 ident: BIB5 article-title: Effect of dietary optimization on growth, survival, tumor incidences and clinical pathology parameters in CD Sprague–Dawley and Fischer-344 rats: a 104-week study publication-title: Drug Chem. Toxicol. contributor: fullname: Bucci – volume: 23 start-page: 475 year: 1985 end-page: 490 ident: BIB48 article-title: Evaluation of the dose response and in utero exposure to saccharin in the rat publication-title: Food Chem. Toxicol. contributor: fullname: Carlborg – volume: 137 start-page: 535 year: 1950 end-page: 549 ident: BIB28 article-title: The hypothalamic control of food intake in rats publication-title: Proc. R. Soc. contributor: fullname: Kennedy – volume: 7 start-page: 45 year: 1977 end-page: 56 ident: BIB47 article-title: The effect of chronic underfeeding on organ weights on rats. How to interpret organ weight changes in cases of marked growth retardation in toxicity tests? publication-title: Toxicology contributor: fullname: Schärer – volume: 92 start-page: 555 year: 1978 end-page: 570 ident: BIB44 article-title: Rats defend different body weights depending on palatability and accessibility of their food publication-title: J. Comp. Physiol. Psychol. contributor: fullname: Peck – volume: 32 start-page: 49 year: 1977 end-page: 57 ident: BIB24 article-title: Age differences in the effects of palatability of diet on regulation of calorie intake and body weight of rats publication-title: J. Gerontol. contributor: fullname: Jakubczak – volume: 20 start-page: 273 year: 1978 end-page: 278 ident: BIB25 article-title: Calorie and water intakes as a function of strain, age, and caloric-density of diet publication-title: Physiol. Behav. contributor: fullname: Jakubczak – volume: 102 start-page: 1477 year: 1972 end-page: 1494 ident: BIB42 article-title: Effect of various restricted dietary regimens on the growth, health, and longevity of albino rats publication-title: J. Nutr. contributor: fullname: Nolen – volume: 47 start-page: 15 year: 1979 end-page: 22 ident: BIB43 article-title: The effect of food restriction for 4 weeks on common toxicity parameters in male rats publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Hiraga – volume: 24 start-page: 757 year: 1996 end-page: 768 ident: BIB27 article-title: The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment publication-title: Toxicol. Pathol. contributor: fullname: Coleman – volume: 20 start-page: 573 year: 1995 end-page: 584 ident: BIB21 article-title: Evolution of the sweetness receptor in primates publication-title: Chem. Senses contributor: fullname: Nofre – start-page: 278 year: 1960 end-page: 292 ident: BIB33 article-title: Robust tests for equality of variances publication-title: Contributions to Probability and Statistics contributor: fullname: Levene – volume: vol. 1 start-page: 337 year: 1967 end-page: 351 ident: BIB29 article-title: Ontogeny of mechanisms controlling food and water intake publication-title: Handbook of Physiology. Section 6, Alimentary Canal contributor: fullname: Kennedy – volume: 39 start-page: 355 year: 1979 end-page: 375 ident: BIB4 article-title: Response of the rat to saccharin with particular reference to the urinary bladder publication-title: Br. J. Cancer contributor: fullname: Hicks – volume: 64 start-page: 976 year: 1986 end-page: 982 ident: BIB32 article-title: Thermogenesis in response to various intakes of palatable food publication-title: Can. J. Physiol. Pharmacol. contributor: fullname: Richard – volume: 13 start-page: 397 year: 1988 end-page: 405 ident: BIB54 article-title: Comparison of aspartame and 4-chloroaspartame taste characteristics in rats and monkeys publication-title: Chem. Senses contributor: fullname: Stewart – start-page: 149 year: 1971 end-page: 260 ident: BIB59 article-title: Design and analysis of single-factor experiments publication-title: Statistical Principles in Experimental Design contributor: fullname: Winer – volume: 38 start-page: 155 year: 2002 end-page: 160 ident: BIB50 article-title: Saccharin as a sugar surrogate revisited publication-title: Appetite contributor: fullname: Sclafani – volume: 49 start-page: 459 year: 1997 end-page: 465 ident: BIB31 article-title: Effect of early body weight and moderate dietary restriction on the survival of the Sprague–Dawley rat publication-title: Exp. Toxicol. Pathol. contributor: fullname: Duprat – volume: 20 start-page: 273 year: 1978 ident: 10.1016/S0273-2300(03)00074-6_BIB25 article-title: Calorie and water intakes as a function of strain, age, and caloric-density of diet publication-title: Physiol. Behav. doi: 10.1016/0031-9384(78)90220-2 contributor: fullname: Jakubczak – volume: 92 start-page: 555 year: 1978 ident: 10.1016/S0273-2300(03)00074-6_BIB44 article-title: Rats defend different body weights depending on palatability and accessibility of their food publication-title: J. Comp. Physiol. Psychol. doi: 10.1037/h0077474 contributor: fullname: Peck – ident: 10.1016/S0273-2300(03)00074-6_BIB53 – start-page: 16 year: 2001 ident: 10.1016/S0273-2300(03)00074-6_BIB9 contributor: fullname: Eaton – volume: 20 start-page: 573 year: 1995 ident: 10.1016/S0273-2300(03)00074-6_BIB21 article-title: Evolution of the sweetness receptor in primates publication-title: Chem. Senses doi: 10.1093/chemse/20.5.573 contributor: fullname: Glaser – ident: 10.1016/S0273-2300(03)00074-6_BIB57 – volume: 7 start-page: 45 year: 1977 ident: 10.1016/S0273-2300(03)00074-6_BIB47 article-title: The effect of chronic underfeeding on organ weights on rats. How to interpret organ weight changes in cases of marked growth retardation in toxicity tests? publication-title: Toxicology doi: 10.1016/0300-483X(77)90037-3 contributor: fullname: Schärer – volume: 38 start-page: 155 year: 2002 ident: 10.1016/S0273-2300(03)00074-6_BIB50 article-title: Saccharin as a sugar surrogate revisited publication-title: Appetite doi: 10.1006/appe.2001.0467 contributor: fullname: Smith – volume: 49 start-page: 459 year: 1997 ident: 10.1016/S0273-2300(03)00074-6_BIB31 article-title: Effect of early body weight and moderate dietary restriction on the survival of the Sprague–Dawley rat publication-title: Exp. Toxicol. Pathol. doi: 10.1016/S0940-2993(97)80135-2 contributor: fullname: Laroque – ident: 10.1016/S0273-2300(03)00074-6_BIB20 – ident: 10.1016/S0273-2300(03)00074-6_BIB14 – volume: 47 start-page: 15 year: 1979 ident: 10.1016/S0273-2300(03)00074-6_BIB43 article-title: The effect of food restriction for 4 weeks on common toxicity parameters in male rats publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/0041-008X(79)90066-8 contributor: fullname: Oishi – ident: 10.1016/S0273-2300(03)00074-6_BIB37 – volume: 13 start-page: 397 year: 1988 ident: 10.1016/S0273-2300(03)00074-6_BIB54 article-title: Comparison of aspartame and 4-chloroaspartame taste characteristics in rats and monkeys publication-title: Chem. Senses doi: 10.1093/chemse/13.3.397 contributor: fullname: Thomsen – volume: 24 start-page: 757 year: 1996 ident: 10.1016/S0273-2300(03)00074-6_BIB27 article-title: The effects of diet, ad libitum overfeeding, and moderate dietary restriction on the rodent bioassay: the uncontrolled variable in safety assessment publication-title: Toxicol. Pathol. doi: 10.1177/019262339602400620 contributor: fullname: Keenan – ident: 10.1016/S0273-2300(03)00074-6_BIB18 – volume: 23 start-page: 475 year: 1985 ident: 10.1016/S0273-2300(03)00074-6_BIB48 article-title: Evaluation of the dose response and in utero exposure to saccharin in the rat publication-title: Food Chem. Toxicol. doi: 10.1016/0278-6915(85)90142-5 contributor: fullname: Schoenig – volume: 38 start-page: S1 issue: Suppl. 2 year: 2000 ident: 10.1016/S0273-2300(03)00074-6_BIB22 article-title: Sucralose—an overview of the toxicity data publication-title: Food Chem. Toxicol. doi: 10.1016/S0278-6915(00)00023-5 contributor: fullname: Grice – volume: 137 start-page: 535 year: 1950 ident: 10.1016/S0273-2300(03)00074-6_BIB28 article-title: The hypothalamic control of food intake in rats publication-title: Proc. R. Soc. doi: 10.1098/rspb.1950.0065 contributor: fullname: Kennedy – volume: 34 start-page: 213 year: 1990 ident: 10.1016/S0273-2300(03)00074-6_BIB34 article-title: Non-linear relationship between reduced energy intake and rate of weight loss in rats publication-title: Ann. Nutr. Metab. doi: 10.1159/000177589 contributor: fullname: Macdonald – ident: 10.1016/S0273-2300(03)00074-6_BIB52 – volume: vol. 1 start-page: 337 year: 1967 ident: 10.1016/S0273-2300(03)00074-6_BIB29 article-title: Ontogeny of mechanisms controlling food and water intake contributor: fullname: Kennedy – ident: 10.1016/S0273-2300(03)00074-6_BIB56 – volume: 64 start-page: 976 year: 1986 ident: 10.1016/S0273-2300(03)00074-6_BIB32 article-title: Thermogenesis in response to various intakes of palatable food publication-title: Can. J. Physiol. Pharmacol. doi: 10.1139/y86-167 contributor: fullname: LeBlanc – start-page: 278 year: 1960 ident: 10.1016/S0273-2300(03)00074-6_BIB33 article-title: Robust tests for equality of variances contributor: fullname: Levene – volume: 22 start-page: 300 year: 1994 ident: 10.1016/S0273-2300(03)00074-6_BIB26 article-title: The effects of overfeeding and dietary restriction on Sprague–Dawley rat survival and early pathology biomarkers of aging publication-title: Toxicol. Pathol. doi: 10.1177/019262339402200308 contributor: fullname: Keenan – volume: 29 start-page: 101 year: 1974 ident: 10.1016/S0273-2300(03)00074-6_BIB45 article-title: Editorial: guidelines on the analysis of tumour rates and death rates in experimental animals publication-title: Br. J. Cancer doi: 10.1038/bjc.1974.45 contributor: fullname: Peto – ident: 10.1016/S0273-2300(03)00074-6_BIB15 – volume: 151 start-page: 110 year: 1947 ident: 10.1016/S0273-2300(03)00074-6_BIB2 article-title: Urges to eat and drink in rats publication-title: Am. J. Physiol. doi: 10.1152/ajplegacy.1947.151.1.110 contributor: fullname: Adolph – volume: 20 start-page: 665 year: 1978 ident: 10.1016/S0273-2300(03)00074-6_BIB30 article-title: Differential effects of quinine and sucrose octa acetate on food intake in the rat publication-title: Physiol. Behav. doi: 10.1016/0031-9384(78)90262-7 contributor: fullname: Kratz – ident: 10.1016/S0273-2300(03)00074-6_BIB36 – start-page: 149 year: 1971 ident: 10.1016/S0273-2300(03)00074-6_BIB59 article-title: Design and analysis of single-factor experiments contributor: fullname: Winer – volume: 20 start-page: 482 year: 1964 ident: 10.1016/S0273-2300(03)00074-6_BIB8 article-title: New tables for multiple comparisons with a control publication-title: Biometrics doi: 10.2307/2528490 contributor: fullname: Dunnett – ident: 10.1016/S0273-2300(03)00074-6_BIB19 – volume: 37 start-page: 253 year: 1986 ident: 10.1016/S0273-2300(03)00074-6_BIB49 article-title: Rats show only a weak preference for the artificial sweetener aspartame publication-title: Physiol. Behav. doi: 10.1016/0031-9384(86)90228-3 contributor: fullname: Sclafani – volume: 32 start-page: 49 year: 1977 ident: 10.1016/S0273-2300(03)00074-6_BIB24 article-title: Age differences in the effects of palatability of diet on regulation of calorie intake and body weight of rats publication-title: J. Gerontol. doi: 10.1093/geronj/32.1.49 contributor: fullname: Jakubczak – start-page: 205 year: 1991 ident: 10.1016/S0273-2300(03)00074-6_BIB41 article-title: In quest of hyperpotent sweeteners contributor: fullname: Nofre – ident: 10.1016/S0273-2300(03)00074-6_BIB11 – ident: 10.1016/S0273-2300(03)00074-6_BIB51 – ident: 10.1016/S0273-2300(03)00074-6_BIB55 – ident: 10.1016/S0273-2300(03)00074-6_BIB39 – ident: 10.1016/S0273-2300(03)00074-6_BIB16 – volume: 12 start-page: 1298 issue: 2 year: 1986 ident: 10.1016/S0273-2300(03)00074-6_BIB46 article-title: A study of taste preferences and polydipsic drinking elicited by saccharin but not aspartame in rat, mouse, and hamster publication-title: Soc. Neurosci. Abstr. contributor: fullname: Pizzi – volume: 58 start-page: 195 year: 2000 ident: 10.1016/S0273-2300(03)00074-6_BIB23 article-title: The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague–Dawley rats publication-title: Toxicol. Sci. doi: 10.1093/toxsci/58.1.195 contributor: fullname: Hubert – volume: 13 start-page: 263 year: 2001 ident: 10.1016/S0273-2300(03)00074-6_BIB6 article-title: The effects of different levels of dietary restriction on aging and survival in the Sprague–Dawley rat: implications for chronic studies publication-title: Aging Clin. Exp. Res. doi: 10.1007/BF03353422 contributor: fullname: Duffy – ident: 10.1016/S0273-2300(03)00074-6_BIB58 – ident: 10.1016/S0273-2300(03)00074-6_BIB3 – ident: 10.1016/S0273-2300(03)00074-6_BIB12 doi: 10.1016/S0273-2300(03)00075-8 – volume: 132 start-page: 101 year: 2002 ident: 10.1016/S0273-2300(03)00074-6_BIB7 article-title: Effect of the AIN-93M purified diet and dietary restriction on survival in Sprague–Dawley rats: implications for chronic studies publication-title: J. Nutr. doi: 10.1093/jn/132.1.101 contributor: fullname: Duffy – volume: 102 start-page: 1477 year: 1972 ident: 10.1016/S0273-2300(03)00074-6_BIB42 article-title: Effect of various restricted dietary regimens on the growth, health, and longevity of albino rats publication-title: J. Nutr. doi: 10.1093/jn/102.11.1477 contributor: fullname: Nolen – volume: 25 start-page: 28 year: 1999 ident: 10.1016/S0273-2300(03)00074-6_BIB1 article-title: Palatability and foraging cost interact to control caloric intake publication-title: J. Exp. Psychol.: Anim. Behav. doi: 10.1037/0097-7403.25.1.28 contributor: fullname: Ackroff – volume: 50 start-page: 163 year: 1966 ident: 10.1016/S0273-2300(03)00074-6_BIB35 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration publication-title: Cancer Chemother. Rep. contributor: fullname: Mantel – ident: 10.1016/S0273-2300(03)00074-6_BIB40 – ident: 10.1016/S0273-2300(03)00074-6_BIB38 – ident: 10.1016/S0273-2300(03)00074-6_BIB17 – volume: 39 start-page: 355 year: 1979 ident: 10.1016/S0273-2300(03)00074-6_BIB4 article-title: Response of the rat to saccharin with particular reference to the urinary bladder publication-title: Br. J. Cancer doi: 10.1038/bjc.1979.68 contributor: fullname: Chowaniec – volume: 8 start-page: 199 year: 1984 ident: 10.1016/S0273-2300(03)00074-6_BIB10 article-title: Preference for sugars and nonnutritive sweeteners in young beagles publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/0149-7634(84)90041-1 contributor: fullname: Ferrell – ident: 10.1016/S0273-2300(03)00074-6_BIB13 – volume: 21 start-page: 97 year: 1998 ident: 10.1016/S0273-2300(03)00074-6_BIB5 article-title: Effect of dietary optimization on growth, survival, tumor incidences and clinical pathology parameters in CD Sprague–Dawley and Fischer-344 rats: a 104-week study publication-title: Drug Chem. Toxicol. doi: 10.3109/01480549809017854 contributor: fullname: Christian |
SSID | ssj0002887 |
Score | 1.8560691 |
Snippet | Safety studies done with neotame, a sweetener with intense taste, demonstrate that changes in bodyweight (BW) and BW gain (BWG) are due to reduced food... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 124 |
SubjectTerms | Administration, Oral Allometric growth Animals Body Weight - drug effects Carcinogenicity Tests Diet Dipeptides - administration & dosage Dipeptides - toxicity Dog Dogs Dose-Response Relationship, Drug Eating - drug effects Embryonic and Fetal Development - drug effects Female Food consumption Food Preferences Male Maternal-Fetal Exchange Mice Neotame Palatability Preference Pregnancy Rat Rats Rats, Sprague-Dawley Sprague–Dawley Sweeteners Sweetening Agents - administration & dosage Sweetening Agents - toxicity Taste Toxicity Tests, Chronic |
Title | Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies |
URI | https://dx.doi.org/10.1016/S0273-2300(03)00074-6 https://www.ncbi.nlm.nih.gov/pubmed/14550755 https://search.proquest.com/docview/19202519 |
Volume | 38 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbJ5lIopU1f20c6hxJaWGftleVHbyF02bY0BJpAbmIsycXQ2svaYetLf1B_ZUeSt6aHUOjNlixbaMajb6T5Roy9Flql5PvkAWoeBnFk93ezhQlCXRSJwEQoY9nIn8-T1VX88Vpc77GzHRfGhlUOtt_bdGeth5L5MJrzdVXNv9hMLASgrZq6UzP22QFNR3E8YQenHz6tzv8Y5EXmzsmzzwe2wUjk8S9xhW9C_ta9J0hum6Jug6BuKlreZ_cGDAmnvpsP2J6pD9nxhU9C3c_gcuRUtTM4hosxPXV_yO76lTrwBKSH7NeyaTQoR8V09gOw1lA0uoetWzcFTw5uwa7ZQm2aDr-bGSBdbqHdGgu7zcbXVi4i3kCHpD3vYHf8SmcVoP4KQ_QINCWs8Rt2Pkl4D5bkAl3zo1L2rqqpoelw00OLpaGS1kc7PmJXy_eXZ6tgOMEhUIS7OjK1qITQsYlEpoUoCIyUqRKcnDKdFbzkWWhQ5Eg-D6ZlmfGYq4zqCWZgXmLCH7NJ3dTmKQNT5MYIpbJFSkZnEWGCKEqjs4SrKErKKTvZCU2ufaIOOUawkZSllbIMuXRSlsmUZTvRyr80TtJk8q-mr3aqIOlvtFssSKN_00rCy9Zpy6fsideQsS-WPp4K8ez_P_uc3RlDCV-wSbe5MS8JEnXFEds_-RkdDYr_GydKCUA |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKOYCEEJTX8uocUAXSppus13lwQxWrBdqqElupN2tiOygSJKtNqiUXfhC_krGdKOJQIXFL_IrlmYw_2_ONGXsjtEpo7ZMFqHkYLCJ7vpvOTRDqPI8FxkIZy0Y-O49Xl4vPV-Jqj50MXBjrVtnbfm_TnbXuU2b9aM42ZTn7aiOxEIC2aupuzbjFbls0YP26jn-Nfh7z1N2SZ0sHtvhI4_FNuMS3IX_nWgnimyaomwCom4iWD9j9HkHCB9_Jh2zPVAfs6MKHoO6msB4ZVc0UjuBiDE7dHbB7fp8OPP3oEfu9rGsNyhExnfUArDTkte5g53ZNwVODG7A7tlCZusUfZgpIjztodsaCbrP1uaXzhzfQIunOexguX2mt-Ktv0PuOQF3ABr9j60OEd2ApLtDWP0tl38qKKpoWtx00WBhKabyv42N2ufy4PlkF_f0NgSLU1ZKhRSWEXphIpFqInKBIkSjBaUmm05wXPA0NigxpxYNJUaR8wVVK-QQyMCsw5k_YflVX5hkDk2fGCKXSeUImZx5hjCgKo9OYqyiKiwk7HoQmNz5Mhxz910jK0kpZhlw6Kct4wtJBtPIvfZM0lfyr6uGgCpL-RXvAgjT6140ktGyXbNmEPfUaMvbFkscTIZ7__2cP2Z3V-uxUnn46__KC3R2dCl-y_XZ7bV4ROGrz1075_wCEKQoV |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Food+consumption+and+body+weight+changes+with+neotame%2C+a+new+sweetener+with+intense+taste%3A+differentiating+effects+of+palatability+from+toxicity+in+dietary+safety+studies&rft.jtitle=Regulatory+toxicology+and+pharmacology&rft.au=Mayhew%2C+Dale+A&rft.au=Comer%2C+C+Phil&rft.au=Stargel%2C+W+Wayne&rft.date=2003-10-01&rft.issn=0273-2300&rft.volume=38&rft.issue=2&rft.spage=124&rft_id=info:doi/10.1016%2FS0273-2300%2803%2900074-6&rft_id=info%3Apmid%2F14550755&rft.externalDocID=14550755 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0273-2300&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0273-2300&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0273-2300&client=summon |