The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and borderline personality disorder in female heroin-dependent Chinese subjects

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 50; pp. 74 - 82
• Main Authors: Yang, Mei, Mamy, Jules, Wang, Qiang, Liao, Yan-Hui, Seewoobudul, Vasish, Xiao, Shui-Yuan, Hao, Wei
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.04.2014
• Subjects: Adult; Alleles; Asian Continental Ancestry Group - genetics; Asian Continental Ancestry Group - psychology; Association study; Borderline personality disorder; Borderline Personality Disorder - complications; Borderline Personality Disorder - genetics; Case-Control Studies; Catechol O-Methyltransferase - genetics; Co-morbidity; Diagnosis, Dual (Psychiatry); Dopamine Plasma Membrane Transport Proteins - genetics; Epistasis, Genetic - genetics; Female; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Heroin dependence; Heroin Dependence - complications; Heroin Dependence - genetics; Heroin Dependence - psychology; Humans; Monoamine Oxidase - genetics; Polymorphism, Genetic - genetics; Receptor, Serotonin, 5-HT2A - genetics; Serotonin Plasma Membrane Transport Proteins - genetics; MAOA-LPR; PS; MAOA; COMT; Gene polymorphism; bp; R; SNP; MDR; LDR; VNTR; Association study; Co-morbidity; 5-HTR2A; 5-HTT; Heroin dependence; DAT; BPD; NE; ASPD; 5-HTTVNTR; 5-HT; STin2VNTR; DA; PCR; Borderline personality disorder
• ISSN: 0278-5846; 1878-4216; 1878-4216
• DOI: 10.1016/j.pnpbp.2013.12.005

To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with co-morbid borderline personality disorder (BPD) in female heroin-dependent patients. In a case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 296 female heroin-dependent patients (including 61 patients with BPD and 235 without BPD) and 101 normal females by genotypes, alleles, and interaction between genes. Female heroin-dependent subjects with BPD have lower frequency of the high activity allele (L: 4 repeats (4R)) of MAOA-LPR than those female heroin-dependent subjects without BPD, and have higher 5-HTTVNTR 10R/10R genotype frequency than normal female controls, with adjusted P-value<0.05 (after adjusted for multiple testing by 1000-fold permutation tests) respectively. By MDR (Multifactor Dimensionality Reduction) analyses, the interactive effects between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 were close to the significance level (P=0.05) in predicting the risk of co-morbidity of BPD and heroin dependence relative to normal female controls, with 1000-fold permutation testing P-value<0.06 however >0.05 respectively. 5-HTTVNTR and MAOA-LPR may have independent predictive effects on co-morbid BPD in female heroin-dependent patients; the gene–gene interactions between MAOA-LPR and 5-HTTVNTR, and among MAOA-LPR, 5-HTTVNTR and rs6311 might also be involved in the etiology of this co-morbidity. •Gene polymorphisms were selected from serotonergic and catecholaminergic systems.•MAOA-LPR was associated with co-morbid BPD in female heroin-dependent patients.•5-HTTVNTR was associated with the co-morbidity of BPD and heroin-dependence.•The interactions among MAOA-LPR, 5-HTTVNTR and rs6311 were close to significance.•The interaction between MAOA-LPR and 5-HTTVNTR was also close to significance level.