Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 67; pp. 92 - 97
• Main Authors: Yi, Buqing, Nichiporuk, Igor, Nicolas, Michel, Schneider, Stefan, Feuerecker, Matthias, Vassilieva, Galina, Thieme, Detlef, Schelling, Gustav, Choukèr, Alexander
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 03.06.2016
• Subjects: 2-Arachidonoylglycerol; Adult; Arachidonic Acids - blood; Brain - physiopathology; Catecholamines - urine; Chromatography, High Pressure Liquid; Chronic stress; Electroencephalography; Endocannabinoid; Endocannabinoids - blood; Female; Glycerides - blood; Healthy Volunteers; HPA axis; Humans; Linear Models; Male; N-arachidonylethanolamine; Psychiatric Status Rating Scales; Stress, Psychological - blood; Stress, Psychological - etiology; Stress, Psychological - physiopathology; Stress, Psychological - urine; Tandem Mass Spectrometry; 2-Arachidonoylglycerol; Chronic stress; HPA axis; Endocannabinoid; N-arachidonylethanolamine

Increasing evidence indicates that chronic stress, such as social isolation, plays an important role in the development of a variety of psychiatric and somatic disorders. Meanwhile, chronic stress imposed by prolonged isolation and confinement in the spacecraft is also one of the major concerns for...