Differences in the Nasal Inflammatory Response to Cynodon dactylon From Rural and Urban Areas in Patients With Allergic Rhinitis
Background Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied. Objectives To explore if th...
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| Published in | Allergy & rhinology (Providence, R.I.) Vol. 9; p. 2152656718815870 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Los Angeles, CA
SAGE Publications
01.01.2018
Sage Publications Ltd |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied.
Objectives
To explore if the growth conditions of the Cynodon dactylon (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis.
Methodology: Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (−) Cyn d.
Results
There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (P = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, P = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test.
Conclusion
The findings suggest that the growth conditions in urban area of Cynodon dactylon can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis. |
|---|---|
| AbstractList | Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied.
To explore if the growth conditions of the
(rural vs urban area) modify the inflammatory response among patients with allergic rhinitis.
Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (-) Cyn d.
There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (
= .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14,
= .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test.
The findings suggest that the growth conditions in urban area of
can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis. Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied.BACKGROUNDEpidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied.To explore if the growth conditions of the Cynodon dactylon (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis.Methodology: Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (-) Cyn d.OBJECTIVESTo explore if the growth conditions of the Cynodon dactylon (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis.Methodology: Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (-) Cyn d.There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (P = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, P = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test.RESULTSThere was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (P = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, P = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test.The findings suggest that the growth conditions in urban area of Cynodon dactylon can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis.CONCLUSIONThe findings suggest that the growth conditions in urban area of Cynodon dactylon can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis. Background Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied. Objectives To explore if the growth conditions of the Cynodon dactylon (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis. Methodology: Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (−) Cyn d. Results There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (P = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, P = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test. Conclusion The findings suggest that the growth conditions in urban area of Cynodon dactylon can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis. Background Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical implications of changes in environmental allergens secondary to air pollution have been little studied. Objectives To explore if the growth conditions of the Cynodon dactylon (rural vs urban area) modify the inflammatory response among patients with allergic rhinitis. Methodology: Two extracts were prepared for diagnostic test with Cyn d proteins obtained from rural and urban environment. Skin prick test (SPT), nasal challenge test (NCT), and eosinophil count in nasal mucus were performed in 3 groups: healthy subjects without rhinitis, rhinitis with (+) Cyn d, and rhinitis with (−) Cyn d. Results There was a 97% concordance in the positive and negative results of the SPT with the 2 extracts. However, Cyn d-urban extract generated larger wheals (P = .03) and a higher number of patients with rhinitis presented a positive NCT to this extract (n = 7 vs 14, P = .04). Patients with positive NCT had a significant increase in eosinophils in mucus, but there was no difference between the extracts. The healthy controls did not react to the extracts tested in the skin or nasal test. Conclusion The findings suggest that the growth conditions in urban area of Cynodon dactylon can generate changes in the protein extract and have clinical implications in patients with allergic rhinitis. |
| Author | Sánchez, Andres Sánchez, Jorge |
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| CitedBy_id | crossref_primary_10_2217_imt_2022_0215 crossref_primary_10_1159_000540646 |
| Cites_doi | 10.29262/ram.v62i4.96 10.1002/alr.21988 10.1016/S0091-6749(99)70011-4 10.1186/s40413-016-0110-7 10.1371/journal.pone.0104520 10.1016/j.jaci.2011.11.021 10.1111/j.1398-9995.2009.02093.x 10.4049/jimmunol.158.5.2406 10.1038/onc.2010.129 10.1016/j.envint.2018.04.048 10.1016/j.scitotenv.2012.02.015 10.1016/j.ijporl.2016.06.008 10.1111/cea.12377 10.1165/ajrcmb.19.3.3143 10.1111/all.12002 10.3892/mmr.2015.3655 10.18176/jiaci.0049 10.1016/j.envpol.2017.02.032 10.1006/clim.2000.4921 10.1371/journal.pone.0031483 10.17533/udea.iatreia.13133 10.1093/aje/kws451 10.1371/journal.pone.0117904 10.1097/EDE.0b013e31816a1ce3 10.1159/000358860 10.1186/s12989-014-0071-3 10.1371/journal.pone.0119501 |
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bibr3-2152656718815870 publication-title: Iatreia doi: 10.17533/udea.iatreia.13133 – ident: bibr5-2152656718815870 doi: 10.1093/aje/kws451 – ident: bibr13-2152656718815870 doi: 10.1371/journal.pone.0117904 – ident: bibr8-2152656718815870 doi: 10.1097/EDE.0b013e31816a1ce3 – ident: bibr9-2152656718815870 doi: 10.1159/000358860 – volume: 21 start-page: 1 issue: 1 year: 2011 ident: bibr19-2152656718815870 publication-title: J Investig Allergol Clin Immunol – ident: bibr2-2152656718815870 doi: 10.1186/s12989-014-0071-3 – ident: bibr20-2152656718815870 doi: 10.1371/journal.pone.0119501 |
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Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the... Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the clinical... Background Epidemiological and experimental studies suggest that air pollution has a negative impact on human health and modifies the environment. However, the... |
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| SubjectTerms | Air pollution Allergies Asthma Leukocytes (eosinophilic) Nose Urban areas |
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| Title | Differences in the Nasal Inflammatory Response to Cynodon dactylon From Rural and Urban Areas in Patients With Allergic Rhinitis |
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