Pharmacology of recombinant low-voltage activated calcium channels

• Published in: Current drug targets. CNS & neurological disorders Vol. 3; no. 2; p. 105
• Main Author: Lacinová, L
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2004
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Anesthetics - pharmacology; Animals; Anticonvulsants - pharmacology; Anticonvulsants - therapeutic use; Antipsychotic Agents - pharmacology; Calcium Channel Blockers - pharmacology; Calcium Channels, T-Type - classification; Calcium Channels, T-Type - drug effects; Calcium Channels, T-Type - metabolism; Cations - pharmacology; Cloning, Molecular; Epilepsy - drug therapy; Epilepsy - physiopathology; Humans; Inorganic Chemicals - pharmacology; Neurons - drug effects; Neurons - metabolism; Rats; Recombinant Proteins - drug effects; Toxins, Biological - pharmacology

Several types of voltage- or ligand-activated calcium channels contribute to the excitability of neuronal cells. Low-voltage-activated (LVA), T-type calcium channels are characterised by relatively negative threshold of activation and therefore they can generate low-threshold spikes, which are essen...