Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force – implications for studies on extracellular vesicles

• Published in: Cellular & molecular biology letters Vol. 20; no. 1; pp. 117 - 129
• Main Authors: Lee, Tae Hoon, Chennakrishnaiah, Shilpa, Rak, Janusz
• Format: Journal Article
• Language: English
• Published: England De Gruyter Open 01.03.2015
• Subjects: Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Extracellular vesicle; Extracellular Vesicles; Filtration; Genes, ras; Genes, src; H-ras; Humans; Hyperacceleration; PP2; TEM; Ultracentrifugation; v-src

Extracellular vesicles (EVs), including exosomes, are a subject of intense interest due to their emission by cancer cells and role in intercellular communication. Earlier reports suggested that oncogenes, such as RAS, MET or EGFR, drive cellular vesiculation. Interestingly, these oncogenes may also...