Prediction of lysine formylation sites using the composition of k-spaced amino acid pairs via Chou's 5-steps rule and general pseudo components

• Published in: Genomics (San Diego, Calif.) Vol. 112; no. 1; pp. 859 - 866
• Main Authors: Ju, Zhe, Wang, Shi-Yun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2020
• Subjects: bioinformatics; chromatin; DNA; epigenetics; Feature extraction; Formylation; histones; lysine; Post-translational modification; prediction; Support vector machine; support vector machines; Post-translational modification; Feature extraction; Formylation; Support vector machine

Lysine formylation is a newly discovered post-translational modification in histones, which plays a crucial role in epigenetics of chromatin function and DNA binding. In this study, a novel bioinformatics tool named CKSAAP_FormSite is proposed to predict lysine formylation sites. An effective featur...