Improvement of succinate production by release of end-product inhibition in Corynebacterium glutamicum

• Published in: Metabolic engineering Vol. 40; pp. 157 - 164
• Main Authors: Chung, Soon-Chun, Park, Joon-Song, Yun, Jiae, Park, Jin Hwan
• Format: Journal Article
• Language: English
• Published: Belgium Elsevier Inc 01.03.2017
• Subjects: batch fermentation; biochemical pathways; Biosynthetic Pathways - physiology; cell growth; Corynebacterium glutamicum; Corynebacterium glutamicum - physiology; End-product inhibition; gene expression regulation; Gene Expression Regulation, Bacterial - physiology; gene overexpression; genes; Genetic Enhancement - methods; glucose; Glucose - metabolism; metabolic engineering; Metabolic Engineering - methods; Metabolic Flux Analysis - methods; Metabolic Networks and Pathways - physiology; NCgl0275; Protein Degradation End Products; Succinate; succinic acid; Succinic Acid - isolation & purification; Succinic Acid - metabolism; Transcriptome analysis; transcriptomics; WhiB-like protein; WhiB-like protein; Transcriptome analysis; NCgl0275; Succinate; End-product inhibition; Corynebacterium glutamicum

Succinate is a renewable-based platform chemical that may be used to produce a wide range of chemicals including 1,4-butanediol, tetrahydrofurane, and γ-butyrolactone. However, industrial fermentation of organic acids is often subject to end-product inhibition, which significantly retards cell growt...