Cortical lesion load associates with progression of disability in multiple sclerosis

• Published in: Brain (London, England : 1878) Vol. 135; no. Pt 10; pp. 2952 - 2961
• Main Authors: CALABRESE, Massimiliano, PORETTO, Valentina, FAVARETTO, Alice, ALESSIO, Sara, BERNARDI, Valentina, ROMUALDI, Chiara, RINALDI, Francesca, PERINI, Paola, GALLO, Paolo
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2012
• Subjects: Adolescent; Adult; Biological and medical sciences; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Child; Disability Evaluation; Female; Humans; Indexing in process; Male; Medical sciences; Middle Aged; Multiple Sclerosis - diagnosis; Multiple Sclerosis - pathology; Multiple Sclerosis - physiopathology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Relapsing-Remitting - diagnosis; Multiple Sclerosis, Relapsing-Remitting - pathology; Multiple Sclerosis, Relapsing-Remitting - physiopathology; Neurologic Examination; Neurology; Phenotype; Prospective Studies; Severity of Illness Index; Young Adult; Disability; Nervous system diseases; Multiple sclerosis; MRI; Central nervous system disease; Inversion recovery; double inversion recovery; disability progression; Nuclear magnetic resonance imaging; cortical lesions; Inflammatory disease

Cortical inflammatory lesions have been correlated with disability and cortical atrophy in multiple sclerosis. The extent to which cortical lesion load is associated with longer-term physical and cognitive disability in different multiple sclerosis phenotypes has not yet been investigated. Thus, a 5...