Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)

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Published inSouthern African journal of infectious diseases Vol. 36; no. 1; pp. e1 - e4
Main Authors Snyman, Yolandi, Whitelaw, Andrew C, Maloba, Motlatji R.B, Hesseling, Anneke C, Newton-Foot, Mae
Format Journal Article
LanguageEnglish
Published African Online Scientific Information Systems (Pty) Ltd t/a AOSIS 23.02.2021
AOSIS
Subjects
Brief Report
cape town
children
Clinical trials
Colistin
colistin resistance
communities
Drug resistance in microorganisms
enterobacterales
Gram-negative bacteria
healthy
Lipids
Medicine, Preventive
Preventive health services
south africa
Tuberculosis
South Africa
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Abstract Abstract only
AbstractList Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.
Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in South Africa. However, information on carriage of these bacteria in communities is limited. This study investigated gastrointestinal carriage of colistin-resistant Escherichia coli and Klebsiella spp. and mcr genes in children from communities in Cape Town. Colistin-resistant E. coli was isolated from two participants (4%, 2/50), and mcr-1-mcr-9 genes were not detected. Gastrointestinal carriage of colistin-resistant Enterobacterales was rare; however, continuous extensive surveillance is necessary to determine the extent of carriage and its contribution to resistance observed in clinical settings.
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Audience Academic
Author Maloba, Motlatji R.B
Whitelaw, Andrew C
Snyman, Yolandi
Newton-Foot, Mae
Hesseling, Anneke C
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Colistin is a last-resort antibiotic against multidrug-resistant, Gram-negative bacteria. Colistin resistance has been described in the clinical settings in...
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SubjectTerms Brief Report
cape town
children
Clinical trials
Colistin
colistin resistance
communities
Drug resistance in microorganisms
enterobacterales
Gram-negative bacteria
healthy
Lipids
Medicine, Preventive
Preventive health services
south africa
Tuberculosis
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Title Carriage of colistin-resistant Gram-negative bacteria in children from communities in Cape Town (Tuberculosis child multidrug-resistant preventive therapy trial sub-study)
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