Type III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to promote bacterial infection

• Published in: Communications biology Vol. 7; no. 1; p. 162
• Main Authors: Zhou, Mengqing, Liu, Yabo, Zhang, Yibei, Ma, Yue, Zhang, Yuanxing, Choi, Sang Ho, Shao, Shuai, Wang, Qiyao
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 09.02.2024; Nature Portfolio
• Subjects: Animals; Bacteria; Bacterial infections; Cell death; Edwardsiella - metabolism; Enterobacteriaceae Infections; Immune clearance; Infections; Inflammation; Intracellular; Macrophages; Mice; Monocytes; Pathogens; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Ribose; Type III Secretion Systems - metabolism; Virulence

Modulation of cell death is a powerful strategy employed by pathogenic bacteria to evade host immune clearance and occupy profitable replication niches during infection. Intracellular pathogens employ the type III secretion system (T3SS) to deliver effectors, which interfere with regulated cell deat...