A comparison between different types of covalent DNA modifications (I-compounds, persistent carcinogen adducts and 5-methylcytosine) in regenerating rat liver

• Published in: Carcinogenesis (New York) Vol. 9; no. 10; p. 1843
• Main Authors: Randerath, K, Lu, L J, Li, D
• Format: Journal Article
• Language: English
• Published: England 01.10.1988
• Subjects: 2-Acetylaminofluorene - metabolism; 5-Methylcytosine; Adenosine Triphosphate - metabolism; Animals; Body Weight; Cytosine - analogs & derivatives; Cytosine - analysis; DNA - metabolism; Liver - metabolism; Liver Regeneration; Male; Organ Size; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Reference Values

I-Compounds have been recently identified as adduct-like nonpolar covalent DNA modifications that are detectable by 32P-postlabeling assay in tissues of untreated experimental animals and increase with age. Additional I-compounds have now been observed in liver DNA of male Sprague-Dawley rats when t...