DHEA and cognitive function in the elderly

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 145; pp. 281 - 292
• Main Authors: Maggio, Marcello, De Vita, Francesca, Fisichella, Alberto, Colizzi, Elena, Provenzano, Sandra, Lauretani, Fulvio, Luci, Michele, Ceresini, Graziano, Dall’Aglio, Elisabetta, Caffarra, Paolo, Valenti, Giorgio, Ceda, Gian Paolo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2015
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Brain - metabolism; Cognition; Cognition Disorders - metabolism; Cognitive function; Cross-Sectional Studies; Dehydroepiandrosterone - metabolism; Dehydroepiandrosterone Sulfate - metabolism; Dementia - metabolism; DHEA; Female; Humans; Longitudinal Studies; Male; Middle Aged; Observational Studies as Topic; Older subjects; Postmenopause; Premenopause; Randomized Controlled Trials as Topic; Steroids - metabolism; DHEA; Cognitive function; Older subjects

•DHEA and DHEAS are classified as neurosteroids.•In vitro and animal studies show a role for DHEA/S in cognitive function.•Cross-Sectional positive association between DHEA/S and cognitive domains.•DHEA/S is not a strong independent predictor of cognitive impairment.•RCTs do not support DHEA treatme...