Replicative senescence in organ transplantation—mechanisms and significance

• Published in: Transplant Immunology Vol. 9; no. 2; pp. 165 - 171
• Main Authors: Chkhotua, A, Shohat, M, Tobar, A, Magal, N, Kaganovski, E, Shapira, Z, Yussim, A
• Format: Book Review Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2002
• Subjects: Animals; Cellular Senescence; Genes, p16 - physiology; Genes, p53 - physiology; Humans; Immunosuppressive Agents - toxicity; Ischemia; Kidney; Kidney - drug effects; Kidney - pathology; Kidney - physiology; Kidney Transplantation - adverse effects; Mechanism; Senescence; Telomere; Transplantation; Senescence; Transplantation; Ischemia; Mechanism; Kidney

In the past two decades, transplantation has become a preferred modality of treatment of end-stage failure of vital organs. Currently, with the significant improvement in short-term graft survival rates, the main effort is concentrated on prolonging the functional life span of transplanted organs. O...