Replicative senescence in organ transplantation—mechanisms and significance
In the past two decades, transplantation has become a preferred modality of treatment of end-stage failure of vital organs. Currently, with the significant improvement in short-term graft survival rates, the main effort is concentrated on prolonging the functional life span of transplanted organs. O...
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Published in | Transplant Immunology Vol. 9; no. 2; pp. 165 - 171 |
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Main Authors | , , , , , , |
Format | Book Review Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.05.2002
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Abstract | In the past two decades, transplantation has become a preferred modality of treatment of end-stage failure of vital organs. Currently, with the significant improvement in short-term graft survival rates, the main effort is concentrated on prolonging the functional life span of transplanted organs. One of the theories which were put forward to explain the progressive deterioration of transplant function was that of replicative senescence. Senescence of an organ or tissue results from age and/or environmental stress-dependant modification of cellular function. With time, the accumulation of cellular alterations may lead to deleterious effects in various organs and tissues and adversely affect transplants. In this article we are reviewing the candidate mechanisms of senescence such as telomere shortening, genetic regulation and environmental–‘toxic’ factors and are examining the implications of the theory of replicative senescence for organ allograft. We are also presenting our experiments with renal ischemia/reperfusion in rat serving as a model of kidney transplantation, where baseline kidney telomere length and novel marker of cellular senescence—senescence associated beta-Galactosidase (SA-Gal) expression in tissue served as markers. For the first time in vivo, we were able to show that with aging of the animals the amount of senescent cells in kidney tissue was increasing, while the average renal tissue telomere length was decreasing. The degree of tissue senescence, as determined by amount of SA-Gal positively stained cells, was inversely correlated with the recovery of the kidney function after ischemia/reperfusion injury. These results confirm the theory of replicative senescence in organ ischemia for the first time in vivo, and quantitatively validate the direct correlation between the amount of senescent cells in the organ and its susceptibility to ischemic injury. We conclude that recent advances in study of the cellular basis of senescence, in vitro and especially in vivo, may hold clues to the understanding of events which could be implicated in the damage or protection of organ allografts. |
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AbstractList | In the past two decades, transplantation has become a preferred modality of treatment of end-stage failure of vital organs. Currently, with the significant improvement in short-term graft survival rates, the main effort is concentrated on prolonging the functional life span of transplanted organs. One of the theories which were put forward to explain the progressive deterioration of transplant function was that of replicative senescence. Senescence of an organ or tissue results from age and/or environmental stress-dependant modification of cellular function. With time, the accumulation of cellular alterations may lead to deleterious effects in various organs and tissues and adversely affect transplants. In this article we are reviewing the candidate mechanisms of senescence such as telomere shortening, genetic regulation and environmental-'toxic' factors and are examining the implications of the theory of replicative senescence for organ allograft. We are also presenting our experiments with renal ischemia/reperfusion in rat serving as a model of kidney transplantation, where baseline kidney telomere length and novel marker of cellular senescence--senescence associated beta-Galactosidase (SA-Gal) expression in tissue served as markers. For the first time in vivo, we were able to show that with aging of the animals the amount of senescent cells in kidney tissue was increasing, while the average renal tissue telomere length was decreasing. The degree of tissue senescence, as determined by amount of SA-Gal positively stained cells, was inversely correlated with the recovery of the kidney function after ischemia/reperfusion injury. These results confirm the theory of replicative senescence in organ ischemia for the first time in vivo, and quantitatively validate the direct correlation between the amount of senescent cells in the organ and its susceptibility to ischemic injury. We conclude that recent advances in study of the cellular basis of senescence, in vitro and especially in vivo, may hold clues to the understanding of events which could be implicated in the damage or protection of organ allografts. |
Author | Kaganovski, E Chkhotua, A Tobar, A Shohat, M Shapira, Z Yussim, A Magal, N |
Author_xml | – sequence: 1 givenname: A surname: Chkhotua fullname: Chkhotua, A organization: Institute of Urology, University of Tbilisi, Georgia – sequence: 2 givenname: M surname: Shohat fullname: Shohat, M organization: Institute of Genetics, Rabin Medical Centre, Tel Aviv University, Israel – sequence: 3 givenname: A surname: Tobar fullname: Tobar, A organization: Institute of Pathology, Rabin Medical Centre, Tel Aviv University, Israel – sequence: 4 givenname: N surname: Magal fullname: Magal, N organization: Institute of Genetics, Rabin Medical Centre, Tel Aviv University, Israel – sequence: 5 givenname: E surname: Kaganovski fullname: Kaganovski, E organization: Institute of Pathology, Rabin Medical Centre, Tel Aviv University, Israel – sequence: 6 givenname: Z surname: Shapira fullname: Shapira, Z organization: Department of Transplantation, Rabin Medical Centre, Tel Aviv University, Israel – sequence: 7 givenname: A surname: Yussim fullname: Yussim, A email: ayussim@post.tau.ac.il organization: Department of Transplantation, Rabin Medical Centre, Tel Aviv University, Israel |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12180826$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1159/000020664 10.1016/S0002-9440(10)64089-8 10.1007/BF00865466 10.3109/08860229909085100 10.1007/s004670050777 10.1097/00007890-199212000-00018 10.1073/pnas.93.24.13742 10.1681/ASN.V781106 10.1038/sj.onc.1201227 10.1046/j.1523-1755.2000.00999.x 10.1016/S0272-6386(97)90567-9 10.1016/0531-5565(82)90032-8 10.1681/ASN.V101167 10.1681/ASN.V113444 10.1006/excr.1999.4398 10.1002/(SICI)1096-9896(199901)187:1<100::AID-PATH236>3.0.CO;2-T 10.1111/j.1600-0773.1990.tb00716.x 10.1038/sj.onc.1201862 10.1038/nbt0598-396 10.1128/MCB.15.9.4745 10.1006/excr.1995.1306 10.1128/MCB.18.4.1793 10.1097/00041552-199805000-00005 10.1038/ki.1993.206 10.1016/S0024-3205(99)00064-8 10.1097/00007890-199608150-00002 10.1016/S0092-8674(00)00046-5 10.1203/00006450-199708000-00016 10.1097/00007890-198908000-00026 10.1097/00007890-199608270-00001 10.1046/j.1523-1755.1999.00696.x 10.1126/science.7605428 10.1097/00007890-199002000-00041 10.1161/01.HYP.27.5.1140 10.1128/MCB.18.3.1611 10.1016/S0749-0690(18)30965-0 10.1681/ASN.V122385 10.1152/ajpcell.1990.259.6.C897 10.1073/pnas.92.18.8348 10.1126/science.277.5327.831 10.1006/excr.1998.4207 10.1016/0006-2952(90)90010-I 10.1111/j.1532-5415.1985.tb07117.x 10.1126/science.279.5349.349 10.1093/carcin/19.1.29 10.1093/ndt/8.8.748 10.1016/S0041-1345(01)02248-5 10.1006/excr.1994.1063 10.1128/MCB.16.3.859 10.1038/sj.onc.1201446 10.1046/j.1523-1755.1998.00202.x |
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References | Atadja, Wong, Garkavtsev, Veillette, Riabowol (BIB15) 1995; 92 Wynford-Thomas, Blaydes (BIB35) 1998; 19 Linderman, Tobin, Shock (BIB5) 1985; 33 Campisi (BIB12) 1998; 16 Amore, Emancipator, Cirina (BIB38) 2000; 57 Chkhotua, Shapira, Tovar, Shabtai, Yussim (BIB64) 2001; 33 Blais, Morvan-Baleynaud, Friedlender, Le Grimrllrc (BIB40) 1993; 44 Adoh, Bennett (BIB56) 1998; 7 Ramirez, Olmo, O'Valle (BIB52) 2000; 8 Xu, Zhou, Ji (BIB31) 1997; 15 Vinik, Pittenger, Rafaeloff, Rosenberg, Duguid (BIB2) 1996; 4 Allsop, Chang, Kashefi-Aazam (BIB19) 1995; 220 Clarke, Ryan (BIB48) 1999; 64 Abassi, Pieruzzi, Nakhoul, Keizer (BIB49) 1996; 27 Boogard, Zoeteweig, Van Berkel, van't Noordende, Mulder, Nagelkerke (BIB39) 1990; 39 Prevot, Semama, Justrabo, Guignard, Escousse, Gouyon (BIB47) 2000; 14 Al Khadar, Al Sulaiman, Kishore, Morais, Tariq (BIB54) 1996; 62 Sokol, Capodagli, Dixon (BIB44) 1990; 269 Kim, Piatyszek, Prowse (BIB9) 1994; 266 Kang, Guo, Park (BIB34) 1998; 9 Moutabarric, Ishibashi, Fukunaga (BIB57) 1992; 54 Kaysen, Myers (BIB10) 1985; 1 Uhrbon, Nister, Westermark (BIB29) 1997; 15 Blaehr, Andersen, Ladeforged (BIB45) 1993; 228 Walker, Lazzaro, Duggin, Horvath, Tiller (BIB58) 1989; 48 Rubin (BIB13) 1998; 16 Hara, Smith, Parry, Tahara, Stone, Peter (BIB28) 1996; 16 Hayflick (BIB11) 1997; 33 Mohrmann, Ansorge, Schmich, Schonfeld, Brandis (BIB41) 1994; 8 Ong, Jewett, Scoble, O'Shea, Varghese, Moorhead (BIB43) 1993; 8 Goyal (BIB4) 1982; 17 Lunz, Contrucci, Ruppert (BIB1) 2001; 158 Shihab, Adoh, Tanner, Bennett (BIB51) 1997; 30 Bond, Wyllie, Wynfold-Thomas (BIB22) 1994; 9 Gire, Wynford-Thomas (BIB27) 1998; 18 Puthenvettil, Frederikson, Reznikoff (BIB36) 1996; 13 Rogan, Bryan, Hukku (BIB23) 1995; 15 Adoh, Lindsley, Franceschini, Bennett (BIB55) 1996; 62 Rosen, Greenfeld, Brezis (BIB50) 1990; 49 Lally, Healy, Ryan (BIB63) 1999; 56 Ceol, Anglani, Vianello (BIB53) 2000; 53 Brown, Wei, Sedivy (BIB17) 1997; 277 Porter, Adoh, Bennett (BIB46) 1999; 21 Melk A, Rayner D, Solez K, Halloran PF. Renal senescence reflects different mechanisms in human and rodent kidneys. Abstracts of Banff Conference on Transplant Pathology. 2001:27. Oexle, Zwirner, Freudenberg, Kohlschutter, Speer (BIB20) 1997; 42 Brady, Zeidel, Kone, Giebisch, Gullans (BIB42) 1993; 265 Healy, Dempsey, Larry, Ryan (BIB59) 1998; 54 Wynford-Thomas (BIB25) 1999; 187 Shihab (BIB62) 1996; 16 Bond, Haughton, Blaydes, Gire, Wynford-Thomas, Wyllie (BIB24) 1996; 13 Gjertson (BIB7) 1997 Epstein (BIB3) 1996; 7 Halloran, Melk, Barth (BIB8) 1999; 10 Bodnar, Quellette, Frolkis (BIB14) 1998; 279 Alcorta, Xiong, Phelps, Hannon, Beach, Barrett (BIB16) 1996; 93 Bennett (BIB61) 1996; 34 Melk, Halloran (BIB67) 2001; 12 (BIB6) 1996 Blaehr, Friis (BIB60) 1990; 66 Robles, Adami (BIB30) 1998; 16 Mondello, Petropoulou, Mouti, Gonos, Franceschi, Nuzzo (BIB32) 1999; 248 Carman, Afshari, Barrett (BIB37) 1998; 244 Vaziri, Schachter, Uchida (BIB18) 1993; 52 Sherr, DePinho (BIB65) 2000; 102 Noda, Ning, Venable, Pereira-Smith, Smith (BIB26) 1994; 211 Melk, Ramassar, Helms (BIB21) 2000; 11 Foster, Wong, Barrett, Galloway (BIB33) 1998; 18 Carman (10.1016/S0966-3274(02)00003-5_BIB37) 1998; 244 Puthenvettil (10.1016/S0966-3274(02)00003-5_BIB36) 1996; 13 Porter (10.1016/S0966-3274(02)00003-5_BIB46) 1999; 21 Halloran (10.1016/S0966-3274(02)00003-5_BIB8) 1999; 10 Ramirez (10.1016/S0966-3274(02)00003-5_BIB52) 2000; 8 Bennett (10.1016/S0966-3274(02)00003-5_BIB61) 1996; 34 Gjertson (10.1016/S0966-3274(02)00003-5_BIB7) 1997 Bond (10.1016/S0966-3274(02)00003-5_BIB24) 1996; 13 Hayflick (10.1016/S0966-3274(02)00003-5_BIB11) 1997; 33 Uhrbon (10.1016/S0966-3274(02)00003-5_BIB29) 1997; 15 Ong (10.1016/S0966-3274(02)00003-5_BIB43) 1993; 8 Brown (10.1016/S0966-3274(02)00003-5_BIB17) 1997; 277 Oexle (10.1016/S0966-3274(02)00003-5_BIB20) 1997; 42 Amore (10.1016/S0966-3274(02)00003-5_BIB38) 2000; 57 Adoh (10.1016/S0966-3274(02)00003-5_BIB55) 1996; 62 Kim (10.1016/S0966-3274(02)00003-5_BIB9) 1994; 266 Boogard (10.1016/S0966-3274(02)00003-5_BIB39) 1990; 39 Lally (10.1016/S0966-3274(02)00003-5_BIB63) 1999; 56 Alcorta (10.1016/S0966-3274(02)00003-5_BIB16) 1996; 93 Prevot (10.1016/S0966-3274(02)00003-5_BIB47) 2000; 14 Clarke (10.1016/S0966-3274(02)00003-5_BIB48) 1999; 64 Hara (10.1016/S0966-3274(02)00003-5_BIB28) 1996; 16 Epstein (10.1016/S0966-3274(02)00003-5_BIB3) 1996; 7 Shihab (10.1016/S0966-3274(02)00003-5_BIB62) 1996; 16 Bodnar (10.1016/S0966-3274(02)00003-5_BIB14) 1998; 279 Kang (10.1016/S0966-3274(02)00003-5_BIB34) 1998; 9 Walker (10.1016/S0966-3274(02)00003-5_BIB58) 1989; 48 Rubin (10.1016/S0966-3274(02)00003-5_BIB13) 1998; 16 Melk (10.1016/S0966-3274(02)00003-5_BIB21) 2000; 11 Chkhotua (10.1016/S0966-3274(02)00003-5_BIB64) 2001; 33 Kaysen (10.1016/S0966-3274(02)00003-5_BIB10) 1985; 1 Bond (10.1016/S0966-3274(02)00003-5_BIB22) 1994; 9 (10.1016/S0966-3274(02)00003-5_BIB6) 1996 Atadja (10.1016/S0966-3274(02)00003-5_BIB15) 1995; 92 Adoh (10.1016/S0966-3274(02)00003-5_BIB56) 1998; 7 Lunz (10.1016/S0966-3274(02)00003-5_BIB1) 2001; 158 Rogan (10.1016/S0966-3274(02)00003-5_BIB23) 1995; 15 Mohrmann (10.1016/S0966-3274(02)00003-5_BIB41) 1994; 8 Blaehr (10.1016/S0966-3274(02)00003-5_BIB60) 1990; 66 Mondello (10.1016/S0966-3274(02)00003-5_BIB32) 1999; 248 Robles (10.1016/S0966-3274(02)00003-5_BIB30) 1998; 16 Gire (10.1016/S0966-3274(02)00003-5_BIB27) 1998; 18 Brady (10.1016/S0966-3274(02)00003-5_BIB42) 1993; 265 Rosen (10.1016/S0966-3274(02)00003-5_BIB50) 1990; 49 Allsop (10.1016/S0966-3274(02)00003-5_BIB19) 1995; 220 Shihab (10.1016/S0966-3274(02)00003-5_BIB51) 1997; 30 Sherr (10.1016/S0966-3274(02)00003-5_BIB65) 2000; 102 10.1016/S0966-3274(02)00003-5_BIB66 Wynford-Thomas (10.1016/S0966-3274(02)00003-5_BIB25) 1999; 187 Sokol (10.1016/S0966-3274(02)00003-5_BIB44) 1990; 269 Abassi (10.1016/S0966-3274(02)00003-5_BIB49) 1996; 27 Melk (10.1016/S0966-3274(02)00003-5_BIB67) 2001; 12 Al Khadar (10.1016/S0966-3274(02)00003-5_BIB54) 1996; 62 Linderman (10.1016/S0966-3274(02)00003-5_BIB5) 1985; 33 Healy (10.1016/S0966-3274(02)00003-5_BIB59) 1998; 54 Goyal (10.1016/S0966-3274(02)00003-5_BIB4) 1982; 17 Blaehr (10.1016/S0966-3274(02)00003-5_BIB45) 1993; 228 Xu (10.1016/S0966-3274(02)00003-5_BIB31) 1997; 15 Vaziri (10.1016/S0966-3274(02)00003-5_BIB18) 1993; 52 Blais (10.1016/S0966-3274(02)00003-5_BIB40) 1993; 44 Foster (10.1016/S0966-3274(02)00003-5_BIB33) 1998; 18 Noda (10.1016/S0966-3274(02)00003-5_BIB26) 1994; 211 Ceol (10.1016/S0966-3274(02)00003-5_BIB53) 2000; 53 Moutabarric (10.1016/S0966-3274(02)00003-5_BIB57) 1992; 54 Wynford-Thomas (10.1016/S0966-3274(02)00003-5_BIB35) 1998; 19 Campisi (10.1016/S0966-3274(02)00003-5_BIB12) 1998; 16 Vinik (10.1016/S0966-3274(02)00003-5_BIB2) 1996; 4 |
References_xml | – volume: 57 start-page: 1549 year: 2000 end-page: 1559 ident: BIB38 article-title: Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells publication-title: Kidney Int contributor: fullname: Cirina – volume: 53 start-page: 8 year: 2000 end-page: 9 ident: BIB53 article-title: Direct effect of chronic cyclosporine treatment on collagen III mRNA expression and deposition in rat kidneys publication-title: Clin Nephrol contributor: fullname: Vianello – volume: 7 start-page: 265 year: 1998 end-page: 270 ident: BIB56 article-title: Chronic cyclosporine nephrotoxicity publication-title: Curr Opin Nephrol Hypertens contributor: fullname: Bennett – volume: 93 start-page: 13742 year: 1996 end-page: 13747 ident: BIB16 article-title: Involvement of cycline dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts publication-title: Proc Natl Acad Sci USA contributor: fullname: Barrett – volume: 19 start-page: 29 year: 1998 end-page: 36 ident: BIB35 article-title: The influence of cell context on the selection pressure for p53 mutation in human cancer publication-title: Carcinogenesis contributor: fullname: Blaydes – volume: 33 start-page: 703 year: 1997 end-page: 709 ident: BIB11 article-title: The limited in vitro lifetime of human diploid cell strains publication-title: Exp Cell Res contributor: fullname: Hayflick – volume: 62 start-page: 311 year: 1996 end-page: 316 ident: BIB55 article-title: Synergistic effects of cyclosporine and rapamycin in a chronic nephrotoxicity model publication-title: Transplantation contributor: fullname: Bennett – volume: 92 start-page: 8348 year: 1995 end-page: 8352 ident: BIB15 article-title: Increased activity of p53 in senescing fibroblasts publication-title: Proc Natl Acad Sci USA contributor: fullname: Riabowol – volume: 16 start-page: 859 year: 1996 end-page: 867 ident: BIB28 article-title: Regulation of p16 CDKN2 expression and its implications for cell immortalisation and senescence publication-title: Mol Cell Biol contributor: fullname: Peter – volume: 269 start-page: C897 year: 1990 end-page: C903 ident: BIB44 article-title: Cyclosporin A and vehicle toxicity in primary cultures of rabbit renal proximal tubular cells publication-title: Am J Physiol contributor: fullname: Dixon – volume: 14 start-page: 370 year: 2000 end-page: 375 ident: BIB47 article-title: Acute cyclosporine A-induced nephrotoxicity: a rabbit model publication-title: Pediatr Nephrol contributor: fullname: Gouyon – volume: 16 start-page: 396 year: 1998 end-page: 397 ident: BIB13 article-title: Telomerase and cellular lifespan: ending the debate? publication-title: Natl Biotechnol contributor: fullname: Rubin – volume: 16 start-page: 536 year: 1996 end-page: 547 ident: BIB62 article-title: Cyclosporine nephropathy: pathophysiology and clinical impact publication-title: Semin Nephrol contributor: fullname: Shihab – volume: 49 start-page: 445 year: 1990 end-page: 452 ident: BIB50 article-title: Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury publication-title: Transplantation contributor: fullname: Brezis – volume: 158 start-page: 1379 year: 2001 end-page: 1390 ident: BIB1 article-title: Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection publication-title: Am J Pathol contributor: fullname: Ruppert – volume: 11 start-page: 444 year: 2000 end-page: 453 ident: BIB21 article-title: Telomere shortening in kidneys with age publication-title: J Am Soc Nephrol contributor: fullname: Helms – volume: 33 start-page: 2910 year: 2001 end-page: 2915 ident: BIB64 article-title: Cellular senescence: a new marker of kidney function recovery after ischemic injury in rats publication-title: Transplant Proc contributor: fullname: Yussim – volume: 16 start-page: 396 year: 1998 end-page: 397 ident: BIB12 article-title: The biology of replicative senescence publication-title: Eur J Cancer contributor: fullname: Campisi – volume: 211 start-page: 90 year: 1994 end-page: 98 ident: BIB26 article-title: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen publication-title: Exp Cell Res contributor: fullname: Smith – volume: 244 start-page: 33 year: 1998 end-page: 42 ident: BIB37 article-title: Cellular senescence in telomerase-expressing Syrian hamster embryo cells publication-title: Exp Cell Res contributor: fullname: Barrett – volume: 9 start-page: 1885 year: 1994 end-page: 1889 ident: BIB22 article-title: Escape from senescence in human diploid fibroblasts induced directly by mutant p53 publication-title: Oncogene contributor: fullname: Wynfold-Thomas – volume: 228 start-page: 283 year: 1993 end-page: 288 ident: BIB45 article-title: Acute effects of FK 506 and cyclosporin A on cultured human proximal tubular cells publication-title: Eur J Pharmacol contributor: fullname: Ladeforged – volume: 4 start-page: 235 year: 1996 end-page: 263 ident: BIB2 article-title: Determinants of pancreatic islet cell mass: a balance between neogenesis and senescence/apoptosis publication-title: Diabetes Rev contributor: fullname: Duguid – volume: 54 start-page: 1955 year: 1998 end-page: 1966 ident: BIB59 article-title: Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line publication-title: Kidney Int contributor: fullname: Ryan – volume: 15 start-page: 4745 year: 1995 end-page: 4753 ident: BIB23 article-title: Alterations in p53 and p16ink4 expression and telomere length during spontaneous immortalisation of Li-Fraumeni syndrome fibroblasts publication-title: Mol Cell Biol contributor: fullname: Hukku – volume: 8 start-page: 748 year: 1993 end-page: 753 ident: BIB43 article-title: Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells publication-title: Nephron Dial Transplant contributor: fullname: Moorhead – volume: 64 start-page: 1295 year: 1999 end-page: 1306 ident: BIB48 article-title: Cyclosporine A induced alterations in magnesium homeostasis in the rat publication-title: Life Sci contributor: fullname: Ryan – volume: 9 start-page: 85 year: 1998 end-page: 95 ident: BIB34 article-title: Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres publication-title: Cell Growth Diff contributor: fullname: Park – volume: 102 start-page: 407 year: 2000 end-page: 410 ident: BIB65 article-title: Cellular senescence: mitotic clock or culture shock? publication-title: Cell contributor: fullname: DePinho – volume: 1 start-page: 207 year: 1985 end-page: 222 ident: BIB10 article-title: The aging kidney publication-title: Clin Geriatr Med contributor: fullname: Myers – volume: 277 start-page: 831 year: 1997 end-page: 834 ident: BIB17 article-title: Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts publication-title: Science contributor: fullname: Sedivy – volume: 12 start-page: 385 year: 2001 end-page: 393 ident: BIB67 article-title: Cell senescence and its implications for nephrology publication-title: J Am Soc Nephrol contributor: fullname: Halloran – volume: 42 start-page: 226 year: 1997 end-page: 231 ident: BIB20 article-title: Examination of telomere length in muscle tissue casts doubt on replicative aging as cause of progression in Duchenne muscular dystrophy publication-title: Pediatr Res contributor: fullname: Speer – volume: 66 start-page: 115 year: 1990 end-page: 120 ident: BIB60 article-title: Acute inhibition of human renal tubular cell growth by cyclosporin A publication-title: Pharmacol Toxicol contributor: fullname: Friis – volume: 15 start-page: 505 year: 1997 end-page: 514 ident: BIB29 article-title: Induction of senescence in human malignant glioma cell by p16 INK4a publication-title: Oncogene contributor: fullname: Westermark – volume: 13 start-page: 2097 year: 1996 end-page: 2104 ident: BIB24 article-title: Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence publication-title: Oncogene contributor: fullname: Wyllie – volume: 16 start-page: 1113 year: 1998 end-page: 1123 ident: BIB30 article-title: Agents that cause DNA double strand breaks lead to p16 INK4a enrichment and the premature senescence of normal fibroblasts publication-title: Oncogene contributor: fullname: Adami – volume: 18 start-page: 1793 year: 1998 end-page: 1801 ident: BIB33 article-title: Inactivation of p16 in human mammary epithelial cells by CpG island methilation publication-title: Mol Cell Biol contributor: fullname: Galloway – volume: 18 start-page: 1611 year: 1998 end-page: 1621 ident: BIB27 article-title: Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti p53 antibodies publication-title: Mol Cell Biol contributor: fullname: Wynford-Thomas – volume: 44 start-page: 13 year: 1993 end-page: 18 ident: BIB40 article-title: Primary culture of rabbit proximal tubules as a cellular model to study nephrotoxicity of xenobiotics publication-title: Kidney Int contributor: fullname: Le Grimrllrc – volume: 54 start-page: 1041 year: 1992 end-page: 1047 ident: BIB57 article-title: FK 506-induced kidney tubular cell injury publication-title: Transplantation contributor: fullname: Fukunaga – volume: 187 start-page: 100 year: 1999 end-page: 111 ident: BIB25 article-title: Cellular senescence and cancer publication-title: J Pathol contributor: fullname: Wynford-Thomas – volume: 30 start-page: 71 year: 1997 end-page: 81 ident: BIB51 article-title: Sodium depletion enhances fibrosis and the excretion of TGF-1 and matrix proteins in experimental chronic cyclosporine nephrotoxicity publication-title: Am J Kidney Dis contributor: fullname: Bennett – volume: 7 start-page: 1006 year: 1996 end-page: 1122 ident: BIB3 article-title: Aging and the kidney publication-title: J Am Soc Nephrol contributor: fullname: Epstein – volume: 279 start-page: 349 year: 1998 end-page: 352 ident: BIB14 article-title: Extension of lifespan by introduction of telomerase into normal human cells publication-title: Science contributor: fullname: Frolkis – volume: 21 start-page: 365 year: 1999 end-page: 368 ident: BIB46 article-title: An animal model of chronic cyclosporine nephrotoxicity publication-title: Renal Fail contributor: fullname: Bennett – volume: 62 start-page: 427 year: 1996 end-page: 435 ident: BIB54 article-title: Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats publication-title: Transplantation contributor: fullname: Tariq – year: 1996 ident: BIB6 publication-title: USRDS 1996 Annual Data Report – start-page: 343 year: 1997 end-page: 360 ident: BIB7 article-title: A multifactor analysis of kidney graft outcomes at 1 and 5 years posttransplantation: 1996 UNOS update publication-title: Clinical Transplants, 12th ed contributor: fullname: Gjertson – volume: 52 start-page: 661 year: 1993 end-page: 667 ident: BIB18 article-title: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes publication-title: Am J Hum Genet contributor: fullname: Uchida – volume: 27 start-page: 1140 year: 1996 end-page: 1148 ident: BIB49 article-title: Effects of cyclosporine A on the synthesis, excretion and metabolism of endothelin in the rat publication-title: Hypertension contributor: fullname: Keizer – volume: 17 start-page: 321 year: 1982 end-page: 331 ident: BIB4 article-title: Changes with age in the human kidney publication-title: Exp Gerontol contributor: fullname: Goyal – volume: 56 start-page: 1254 year: 1999 ident: BIB63 article-title: Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells publication-title: Kidney Int contributor: fullname: Ryan – volume: 220 start-page: 194 year: 1995 end-page: 200 ident: BIB19 article-title: Telomere shortening is associated well with cell division in vitro and in vivo publication-title: Exp Cell Res contributor: fullname: Kashefi-Aazam – volume: 248 start-page: 234 year: 1999 end-page: 242 ident: BIB32 article-title: Telomere length in fibroblasts and blood cells from healthy centerians publication-title: Exp Cell Res contributor: fullname: Nuzzo – volume: 39 start-page: 1335 year: 1990 end-page: 1345 ident: BIB39 article-title: Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity. Toxicity of nephrotoxins at low concentrations during prolonged exposure publication-title: Biochem Pharmacol contributor: fullname: Nagelkerke – volume: 265 start-page: 1421 year: 1993 end-page: 1428 ident: BIB42 article-title: Differential actions of cisplantin on renal proximal tubule and inner medullary collecting duct cells publication-title: J Pharmacol Exp Ther contributor: fullname: Gullans – volume: 13 start-page: 1123 year: 1996 end-page: 1131 ident: BIB36 article-title: Apoptosis in human papilomavirus 16 E7—but not E6—immortalized human uroepithelial cells publication-title: Oncogene contributor: fullname: Reznikoff – volume: 10 start-page: 167 year: 1999 end-page: 181 ident: BIB8 article-title: Rethinking chronic allograft nephropathy: the concept of accelerated senescence publication-title: J Am Soc Nephrol contributor: fullname: Barth – volume: 48 start-page: 321 year: 1989 end-page: 327 ident: BIB58 article-title: Structure–activity relationships of cyclosporines. Toxicity in cultured renal tubular epithelial cells publication-title: Transplantation contributor: fullname: Tiller – volume: 34 start-page: 515 year: 1996 end-page: 519 ident: BIB61 article-title: Insights into cyclosporine nephrotoxicity publication-title: Int J Pharmacol Ther contributor: fullname: Bennett – volume: 266 start-page: 2011 year: 1994 end-page: 2015 ident: BIB9 article-title: Specific association of human telomerase activity with immortal cells and cancer publication-title: Science contributor: fullname: Prowse – volume: 8 start-page: 161 year: 2000 end-page: 172 ident: BIB52 article-title: Role of intrarenal endothelin 1, endothelin 3 and angiotenzin II expression in chronic cyclosporin A nephrotoxicity in rats publication-title: Exp Nephrol contributor: fullname: O'Valle – volume: 33 start-page: 278 year: 1985 end-page: 285 ident: BIB5 article-title: Longitudinal studies on the rate of decline in renal function with age publication-title: J Am Geriatr Soc contributor: fullname: Shock – volume: 8 start-page: 157 year: 1994 end-page: 163 ident: BIB41 article-title: Toxicity of cyclophosphamide and their metabolites in renal tubular cells in culture publication-title: Pediatr Nephrol contributor: fullname: Brandis – volume: 15 start-page: 2589 year: 1997 end-page: 2596 ident: BIB31 article-title: Reexpression of retinoblastoma protein in tumor cells induces senescence and telomerase inhibition publication-title: Oncogene contributor: fullname: Ji – volume: 34 start-page: 515 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB61 article-title: Insights into cyclosporine nephrotoxicity publication-title: Int J Pharmacol Ther contributor: fullname: Bennett – volume: 8 start-page: 161 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB52 article-title: Role of intrarenal endothelin 1, endothelin 3 and angiotenzin II expression in chronic cyclosporin A nephrotoxicity in rats publication-title: Exp Nephrol doi: 10.1159/000020664 contributor: fullname: Ramirez – year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB6 – volume: 158 start-page: 1379 year: 2001 ident: 10.1016/S0966-3274(02)00003-5_BIB1 article-title: Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64089-8 contributor: fullname: Lunz – volume: 8 start-page: 157 year: 1994 ident: 10.1016/S0966-3274(02)00003-5_BIB41 article-title: Toxicity of cyclophosphamide and their metabolites in renal tubular cells in culture publication-title: Pediatr Nephrol doi: 10.1007/BF00865466 contributor: fullname: Mohrmann – volume: 13 start-page: 1123 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB36 article-title: Apoptosis in human papilomavirus 16 E7—but not E6—immortalized human uroepithelial cells publication-title: Oncogene contributor: fullname: Puthenvettil – volume: 21 start-page: 365 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB46 article-title: An animal model of chronic cyclosporine nephrotoxicity publication-title: Renal Fail doi: 10.3109/08860229909085100 contributor: fullname: Porter – volume: 14 start-page: 370 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB47 article-title: Acute cyclosporine A-induced nephrotoxicity: a rabbit model publication-title: Pediatr Nephrol doi: 10.1007/s004670050777 contributor: fullname: Prevot – volume: 54 start-page: 1041 year: 1992 ident: 10.1016/S0966-3274(02)00003-5_BIB57 article-title: FK 506-induced kidney tubular cell injury publication-title: Transplantation doi: 10.1097/00007890-199212000-00018 contributor: fullname: Moutabarric – volume: 93 start-page: 13742 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB16 article-title: Involvement of cycline dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.24.13742 contributor: fullname: Alcorta – volume: 7 start-page: 1006 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB3 article-title: Aging and the kidney publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V781106 contributor: fullname: Epstein – volume: 15 start-page: 505 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB29 article-title: Induction of senescence in human malignant glioma cell by p16 INK4a publication-title: Oncogene doi: 10.1038/sj.onc.1201227 contributor: fullname: Uhrbon – ident: 10.1016/S0966-3274(02)00003-5_BIB66 – volume: 57 start-page: 1549 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB38 article-title: Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells publication-title: Kidney Int doi: 10.1046/j.1523-1755.2000.00999.x contributor: fullname: Amore – volume: 30 start-page: 71 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB51 article-title: Sodium depletion enhances fibrosis and the excretion of TGF-1 and matrix proteins in experimental chronic cyclosporine nephrotoxicity publication-title: Am J Kidney Dis doi: 10.1016/S0272-6386(97)90567-9 contributor: fullname: Shihab – volume: 17 start-page: 321 year: 1982 ident: 10.1016/S0966-3274(02)00003-5_BIB4 article-title: Changes with age in the human kidney publication-title: Exp Gerontol doi: 10.1016/0531-5565(82)90032-8 contributor: fullname: Goyal – volume: 10 start-page: 167 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB8 article-title: Rethinking chronic allograft nephropathy: the concept of accelerated senescence publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V101167 contributor: fullname: Halloran – volume: 33 start-page: 703 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB11 article-title: The limited in vitro lifetime of human diploid cell strains publication-title: Exp Cell Res contributor: fullname: Hayflick – volume: 11 start-page: 444 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB21 article-title: Telomere shortening in kidneys with age publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V113444 contributor: fullname: Melk – volume: 248 start-page: 234 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB32 article-title: Telomere length in fibroblasts and blood cells from healthy centerians publication-title: Exp Cell Res doi: 10.1006/excr.1999.4398 contributor: fullname: Mondello – volume: 187 start-page: 100 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB25 article-title: Cellular senescence and cancer publication-title: J Pathol doi: 10.1002/(SICI)1096-9896(199901)187:1<100::AID-PATH236>3.0.CO;2-T contributor: fullname: Wynford-Thomas – volume: 66 start-page: 115 year: 1990 ident: 10.1016/S0966-3274(02)00003-5_BIB60 article-title: Acute inhibition of human renal tubular cell growth by cyclosporin A publication-title: Pharmacol Toxicol doi: 10.1111/j.1600-0773.1990.tb00716.x contributor: fullname: Blaehr – volume: 16 start-page: 1113 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB30 article-title: Agents that cause DNA double strand breaks lead to p16 INK4a enrichment and the premature senescence of normal fibroblasts publication-title: Oncogene doi: 10.1038/sj.onc.1201862 contributor: fullname: Robles – volume: 16 start-page: 396 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB13 article-title: Telomerase and cellular lifespan: ending the debate? publication-title: Natl Biotechnol doi: 10.1038/nbt0598-396 contributor: fullname: Rubin – volume: 15 start-page: 4745 year: 1995 ident: 10.1016/S0966-3274(02)00003-5_BIB23 article-title: Alterations in p53 and p16ink4 expression and telomere length during spontaneous immortalisation of Li-Fraumeni syndrome fibroblasts publication-title: Mol Cell Biol doi: 10.1128/MCB.15.9.4745 contributor: fullname: Rogan – volume: 220 start-page: 194 year: 1995 ident: 10.1016/S0966-3274(02)00003-5_BIB19 article-title: Telomere shortening is associated well with cell division in vitro and in vivo publication-title: Exp Cell Res doi: 10.1006/excr.1995.1306 contributor: fullname: Allsop – volume: 18 start-page: 1793 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB33 article-title: Inactivation of p16 in human mammary epithelial cells by CpG island methilation publication-title: Mol Cell Biol doi: 10.1128/MCB.18.4.1793 contributor: fullname: Foster – volume: 9 start-page: 85 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB34 article-title: Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres publication-title: Cell Growth Diff contributor: fullname: Kang – volume: 7 start-page: 265 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB56 article-title: Chronic cyclosporine nephrotoxicity publication-title: Curr Opin Nephrol Hypertens doi: 10.1097/00041552-199805000-00005 contributor: fullname: Adoh – volume: 44 start-page: 13 year: 1993 ident: 10.1016/S0966-3274(02)00003-5_BIB40 article-title: Primary culture of rabbit proximal tubules as a cellular model to study nephrotoxicity of xenobiotics publication-title: Kidney Int doi: 10.1038/ki.1993.206 contributor: fullname: Blais – volume: 64 start-page: 1295 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB48 article-title: Cyclosporine A induced alterations in magnesium homeostasis in the rat publication-title: Life Sci doi: 10.1016/S0024-3205(99)00064-8 contributor: fullname: Clarke – volume: 62 start-page: 311 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB55 article-title: Synergistic effects of cyclosporine and rapamycin in a chronic nephrotoxicity model publication-title: Transplantation doi: 10.1097/00007890-199608150-00002 contributor: fullname: Adoh – volume: 102 start-page: 407 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB65 article-title: Cellular senescence: mitotic clock or culture shock? publication-title: Cell doi: 10.1016/S0092-8674(00)00046-5 contributor: fullname: Sherr – volume: 42 start-page: 226 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB20 article-title: Examination of telomere length in muscle tissue casts doubt on replicative aging as cause of progression in Duchenne muscular dystrophy publication-title: Pediatr Res doi: 10.1203/00006450-199708000-00016 contributor: fullname: Oexle – volume: 16 start-page: 396 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB12 article-title: The biology of replicative senescence publication-title: Eur J Cancer contributor: fullname: Campisi – volume: 4 start-page: 235 issue: 2 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB2 article-title: Determinants of pancreatic islet cell mass: a balance between neogenesis and senescence/apoptosis publication-title: Diabetes Rev contributor: fullname: Vinik – volume: 48 start-page: 321 year: 1989 ident: 10.1016/S0966-3274(02)00003-5_BIB58 article-title: Structure–activity relationships of cyclosporines. Toxicity in cultured renal tubular epithelial cells publication-title: Transplantation doi: 10.1097/00007890-198908000-00026 contributor: fullname: Walker – volume: 62 start-page: 427 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB54 article-title: Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats publication-title: Transplantation doi: 10.1097/00007890-199608270-00001 contributor: fullname: Al Khadar – volume: 56 start-page: 1254 year: 1999 ident: 10.1016/S0966-3274(02)00003-5_BIB63 article-title: Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells publication-title: Kidney Int doi: 10.1046/j.1523-1755.1999.00696.x contributor: fullname: Lally – start-page: 343 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB7 article-title: A multifactor analysis of kidney graft outcomes at 1 and 5 years posttransplantation: 1996 UNOS update contributor: fullname: Gjertson – volume: 266 start-page: 2011 year: 1994 ident: 10.1016/S0966-3274(02)00003-5_BIB9 article-title: Specific association of human telomerase activity with immortal cells and cancer publication-title: Science doi: 10.1126/science.7605428 contributor: fullname: Kim – volume: 49 start-page: 445 year: 1990 ident: 10.1016/S0966-3274(02)00003-5_BIB50 article-title: Chronic cyclosporine-induced nephropathy in the rat. A medullary ray and inner stripe injury publication-title: Transplantation doi: 10.1097/00007890-199002000-00041 contributor: fullname: Rosen – volume: 13 start-page: 2097 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB24 article-title: Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence publication-title: Oncogene contributor: fullname: Bond – volume: 27 start-page: 1140 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB49 article-title: Effects of cyclosporine A on the synthesis, excretion and metabolism of endothelin in the rat publication-title: Hypertension doi: 10.1161/01.HYP.27.5.1140 contributor: fullname: Abassi – volume: 265 start-page: 1421 year: 1993 ident: 10.1016/S0966-3274(02)00003-5_BIB42 article-title: Differential actions of cisplantin on renal proximal tubule and inner medullary collecting duct cells publication-title: J Pharmacol Exp Ther contributor: fullname: Brady – volume: 18 start-page: 1611 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB27 article-title: Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti p53 antibodies publication-title: Mol Cell Biol doi: 10.1128/MCB.18.3.1611 contributor: fullname: Gire – volume: 1 start-page: 207 year: 1985 ident: 10.1016/S0966-3274(02)00003-5_BIB10 article-title: The aging kidney publication-title: Clin Geriatr Med doi: 10.1016/S0749-0690(18)30965-0 contributor: fullname: Kaysen – volume: 12 start-page: 385 year: 2001 ident: 10.1016/S0966-3274(02)00003-5_BIB67 article-title: Cell senescence and its implications for nephrology publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V122385 contributor: fullname: Melk – volume: 269 start-page: C897 year: 1990 ident: 10.1016/S0966-3274(02)00003-5_BIB44 article-title: Cyclosporin A and vehicle toxicity in primary cultures of rabbit renal proximal tubular cells publication-title: Am J Physiol doi: 10.1152/ajpcell.1990.259.6.C897 contributor: fullname: Sokol – volume: 9 start-page: 1885 year: 1994 ident: 10.1016/S0966-3274(02)00003-5_BIB22 article-title: Escape from senescence in human diploid fibroblasts induced directly by mutant p53 publication-title: Oncogene contributor: fullname: Bond – volume: 52 start-page: 661 year: 1993 ident: 10.1016/S0966-3274(02)00003-5_BIB18 article-title: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes publication-title: Am J Hum Genet contributor: fullname: Vaziri – volume: 16 start-page: 536 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB62 article-title: Cyclosporine nephropathy: pathophysiology and clinical impact publication-title: Semin Nephrol contributor: fullname: Shihab – volume: 92 start-page: 8348 year: 1995 ident: 10.1016/S0966-3274(02)00003-5_BIB15 article-title: Increased activity of p53 in senescing fibroblasts publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.92.18.8348 contributor: fullname: Atadja – volume: 277 start-page: 831 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB17 article-title: Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts publication-title: Science doi: 10.1126/science.277.5327.831 contributor: fullname: Brown – volume: 244 start-page: 33 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB37 article-title: Cellular senescence in telomerase-expressing Syrian hamster embryo cells publication-title: Exp Cell Res doi: 10.1006/excr.1998.4207 contributor: fullname: Carman – volume: 39 start-page: 1335 year: 1990 ident: 10.1016/S0966-3274(02)00003-5_BIB39 article-title: Primary culture of proximal tubular cells from normal rat kidney as an in vitro model to study mechanisms of nephrotoxicity. Toxicity of nephrotoxins at low concentrations during prolonged exposure publication-title: Biochem Pharmacol doi: 10.1016/0006-2952(90)90010-I contributor: fullname: Boogard – volume: 33 start-page: 278 year: 1985 ident: 10.1016/S0966-3274(02)00003-5_BIB5 article-title: Longitudinal studies on the rate of decline in renal function with age publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.1985.tb07117.x contributor: fullname: Linderman – volume: 279 start-page: 349 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB14 article-title: Extension of lifespan by introduction of telomerase into normal human cells publication-title: Science doi: 10.1126/science.279.5349.349 contributor: fullname: Bodnar – volume: 19 start-page: 29 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB35 article-title: The influence of cell context on the selection pressure for p53 mutation in human cancer publication-title: Carcinogenesis doi: 10.1093/carcin/19.1.29 contributor: fullname: Wynford-Thomas – volume: 8 start-page: 748 year: 1993 ident: 10.1016/S0966-3274(02)00003-5_BIB43 article-title: Effect of cyclosporin A on endothelin synthesis by cultured human renal cortical epithelial cells publication-title: Nephron Dial Transplant doi: 10.1093/ndt/8.8.748 contributor: fullname: Ong – volume: 33 start-page: 2910 issue: 6 year: 2001 ident: 10.1016/S0966-3274(02)00003-5_BIB64 article-title: Cellular senescence: a new marker of kidney function recovery after ischemic injury in rats publication-title: Transplant Proc doi: 10.1016/S0041-1345(01)02248-5 contributor: fullname: Chkhotua – volume: 211 start-page: 90 year: 1994 ident: 10.1016/S0966-3274(02)00003-5_BIB26 article-title: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen publication-title: Exp Cell Res doi: 10.1006/excr.1994.1063 contributor: fullname: Noda – volume: 16 start-page: 859 year: 1996 ident: 10.1016/S0966-3274(02)00003-5_BIB28 article-title: Regulation of p16 CDKN2 expression and its implications for cell immortalisation and senescence publication-title: Mol Cell Biol doi: 10.1128/MCB.16.3.859 contributor: fullname: Hara – volume: 15 start-page: 2589 year: 1997 ident: 10.1016/S0966-3274(02)00003-5_BIB31 article-title: Reexpression of retinoblastoma protein in tumor cells induces senescence and telomerase inhibition publication-title: Oncogene doi: 10.1038/sj.onc.1201446 contributor: fullname: Xu – volume: 228 start-page: 283 year: 1993 ident: 10.1016/S0966-3274(02)00003-5_BIB45 article-title: Acute effects of FK 506 and cyclosporin A on cultured human proximal tubular cells publication-title: Eur J Pharmacol contributor: fullname: Blaehr – volume: 54 start-page: 1955 year: 1998 ident: 10.1016/S0966-3274(02)00003-5_BIB59 article-title: Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line publication-title: Kidney Int doi: 10.1046/j.1523-1755.1998.00202.x contributor: fullname: Healy – volume: 53 start-page: 8 year: 2000 ident: 10.1016/S0966-3274(02)00003-5_BIB53 article-title: Direct effect of chronic cyclosporine treatment on collagen III mRNA expression and deposition in rat kidneys publication-title: Clin Nephrol contributor: fullname: Ceol |
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SubjectTerms | Animals Cellular Senescence Genes, p16 - physiology Genes, p53 - physiology Humans Immunosuppressive Agents - toxicity Ischemia Kidney Kidney - drug effects Kidney - pathology Kidney - physiology Kidney Transplantation - adverse effects Mechanism Senescence Telomere Transplantation |
Title | Replicative senescence in organ transplantation—mechanisms and significance |
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