Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins

14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3ζ. The zetin 1/rBSPRY g...

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Published inBiochemical and biophysical research communications Vol. 302; no. 3; pp. 526 - 533
Main Authors Birkenfeld, Jörg, Kartmann, Bettina, Anliker, Brigitte, Ono, Koji, Schlötcke, Britta, Betz, Heinrich, Roth, Dagmar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.03.2003
Subjects
14-3-3 Proteins
Actin
Amino Acid Sequence
Animals
B-box
Blotting, Northern
Brain - metabolism
Brain expression
Cell Line
COS Cells
DNA, Complementary - metabolism
Gene Library
Humans
In Situ Hybridization
Molecular Sequence Data
Plasmids - metabolism
Precipitin Tests
Protein Binding
Protein Biosynthesis
Protein Isoforms
Proteins - chemistry
Proteins - metabolism
Rats
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Sequence Homology, Amino Acid
SPRY domain
Tissue Distribution
Transcription, Genetic
Transfection
Two-Hybrid System Techniques
Tyrosine 3-Monooxygenase - metabolism
B-box
SPRY domain
14-3-3 Proteins
Brain expression
Actin
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Abstract 14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3ζ. The zetin 1/rBSPRY gene is ubiquitously expressed in a variety of rat tissues, with highest expression being found in testis. In adult brain, high levels of zetin 1/rBSPRY mRNA were observed in the hippocampus, cereberal cortex, and piriform cortex. Biochemical studies confirmed zetin 1/rBSPRY to interact with 14-3-3ζ. Transient co-transfection in COS 7 cells caused a partial redistribution of zetin 1/rBSPRY into 14-3-3ζ enriched submembranous foci at leading edges. Our results suggest a role for zetin 1/rBSPRY-14-3-3 interactions at specialized submembrane domains.
AbstractList 14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3 zeta . The zetin 1/rBSPRY gene is ubiquitously expressed in a variety of rat tissues, with highest expression being found in testis. In adult brain, high levels of zetin 1 /rBSPRY mRNA were observed in the hippocampus, cereberal cortex, and piriform cortex. Biochemical studies confirmed zetin 1/rBSPRY to interact with 14-3-3 zeta . Transient co-transfection in COS 7 cells caused a partial redistribution of zetin 1/rBSPRY into 14-3-3 zeta enriched submembranous foci at leading edges. Our results suggest a role for zetin 1/rBSPRY-14-3-3 interactions at specialized submembrane domains.
14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3ζ. The zetin 1/rBSPRY gene is ubiquitously expressed in a variety of rat tissues, with highest expression being found in testis. In adult brain, high levels of zetin 1/rBSPRY mRNA were observed in the hippocampus, cereberal cortex, and piriform cortex. Biochemical studies confirmed zetin 1/rBSPRY to interact with 14-3-3ζ. Transient co-transfection in COS 7 cells caused a partial redistribution of zetin 1/rBSPRY into 14-3-3ζ enriched submembranous foci at leading edges. Our results suggest a role for zetin 1/rBSPRY-14-3-3 interactions at specialized submembrane domains.
14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid screening of a rat brain cDNA library identified a novel gene product termed zetin 1/rBSPRY that interacts with 14-3-3 zeta. The zetin 1/rBSPRY gene is ubiquitously expressed in a variety of rat tissues, with highest expression being found in testis. In adult brain, high levels of zetin 1/rBSPRY mRNA were observed in the hippocampus, cerebral cortex, and piriform cortex. Biochemical studies confirmed zetin 1/rBSPRY to interact with 14-3-3 zeta. Transient co-transfection in COS 7 cells caused a partial redistribution of zetin 1/rBSPRY into 14-3-3 zeta enriched submembranous foci at leading edges. Our results suggest a role for zetin 1/rBSPRY-14-3-3 interactions at specialized submembrane domains.
Author Kartmann, Bettina
Ono, Koji
Betz, Heinrich
Roth, Dagmar
Schlötcke, Britta
Birkenfeld, Jörg
Anliker, Brigitte
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CitedBy_id crossref_primary_10_18632_oncotarget_807
crossref_primary_10_1074_jbc_M609057200
crossref_primary_10_1111_j_1440_1681_2006_04378_x
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Keywords B-box
SPRY domain
14-3-3 Proteins
Brain expression
Actin
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Snippet 14-3-3 proteins are ubiquitously expressed proteins which serve as central adaptors in different signal transduction cascades. In this study, yeast two-hybrid...
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SubjectTerms 14-3-3 Proteins
Actin
Amino Acid Sequence
Animals
B-box
Blotting, Northern
Brain - metabolism
Brain expression
Cell Line
COS Cells
DNA, Complementary - metabolism
Gene Library
Humans
In Situ Hybridization
Molecular Sequence Data
Plasmids - metabolism
Precipitin Tests
Protein Binding
Protein Biosynthesis
Protein Isoforms
Proteins - chemistry
Proteins - metabolism
Rats
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Sequence Homology, Amino Acid
SPRY domain
Tissue Distribution
Transcription, Genetic
Transfection
Two-Hybrid System Techniques
Tyrosine 3-Monooxygenase - metabolism
Title Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins
URI https://dx.doi.org/10.1016/S0006-291X(03)00182-7
https://www.ncbi.nlm.nih.gov/pubmed/12615066
https://search.proquest.com/docview/20631372
https://search.proquest.com/docview/73067599
Volume 302
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