Quantitative proteomics revealed novel proteins associated with molecular subtypes of breast cancer

• Published in: Journal of proteomics Vol. 148; pp. 183 - 193
• Main Authors: Suman, Shankar, Basak, Trayambak, Gupta, Prachi, Mishra, Sanjay, Kumar, Vijay, Sengupta, Shantanu, Shukla, Yogeshwer
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 04.10.2016
• Subjects: Adult; Alpha-2-macroglobulin; alpha-Macroglobulins - analysis; BC subtypes; Biomarkers, Tumor - analysis; blood plasma; breast neoplasms; Breast Neoplasms - chemistry; Breast Neoplasms - classification; Breast Neoplasms - diagnosis; Case-Control Studies; complement; Complement C4b-Binding Protein - analysis; Complement component-4-binding protein-alpha; Complement factor-B; data analysis; early diagnosis; Female; Fibronectin; fibronectins; Fibronectins - analysis; Gene Expression Regulation, Neoplastic; Humans; iTRAQ; Membrane Glycoproteins; Middle Aged; neoplasm cells; patients; prognosis; proteomics; Proteomics - methods; Receptor, ErbB-2; regression analysis; therapeutics; Triple Negative Breast Neoplasms; iTRAQ; Alpha-2-macroglobulin; BC subtypes; Complement component-4-binding protein-alpha; Complement factor-B; Fibronectin

The early diagnosis and successful treatment of breast cancer (BC) is still a challenging task due to the diverse origin and functional heterogeneity of cancer cells. The heterogeneity of BC may likely to explained by molecular BC subtypes, comprises Luminal-A (LA), Luminal-B (LB), Triple-negative (...