Subtle upper limb impairment in asymptomatic multiple sclerosis subjects
We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and...
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| Published in | Multiple sclerosis Vol. 13; no. 3; pp. 428 - 432 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London, England
SAGE Publications
01.04.2007
Arnold Sage Publications Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1352-4585 1477-0970 |
| DOI | 10.1177/1352458506069926 |
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| Abstract | We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. Multiple Sclerosis 2007; 13: 428-432. http://msj.sagepub.com |
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| AbstractList | We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. Multiple Sclerosis 2007; 13: 428-432. http://msj.sagepub.com We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. Multiple Sclerosis 2007; 13: 428-432. http://msj.sagepub.com [PUBLICATION ABSTRACT] We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control.We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. We evaluated upper limb function in multiple sclerosis (MS) subjects (11 clinically definite MS patients and seven clinically isolated syndrome (CIS) subjects), with a normal upper limb standard neurological examination. Subjects performed center-out reaching movements under visual control, with and without vision of the hand. Their movements were recorded through a digitizing tablet. Motor performance was also related to lesion load, estimated from magnetic resonance imaging (MRI). We found that in MS and CIS subjects, under the hand vision condition, movements were significantly less smooth, and had a less symmetric speed profile. However, the observed impairment did not correlate with MRI findings. This result may be interpreted as evidence of a compensatory strategy, elicited by subtle alterations in sensorimotor control. |
| Author | Brichetto, G. Roccatagliata, L. Morasso, P.G. Tanganelli, P. Mancardi, G.L. Casadio, M. Ruggiu, P. Solaro, C. Sanguineti, V. |
| Author_xml | – sequence: 1 givenname: C. surname: Solaro fullname: Solaro, C. email: csolaro@libero.it organization: Department of Neurology, Hospital 'P Antero Micone', Genova, Italy – sequence: 2 givenname: G. surname: Brichetto fullname: Brichetto, G. organization: Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy – sequence: 3 givenname: M. surname: Casadio fullname: Casadio, M. organization: Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy – sequence: 4 givenname: L. surname: Roccatagliata fullname: Roccatagliata, L. organization: Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy – sequence: 5 givenname: P. surname: Ruggiu fullname: Ruggiu, P. organization: Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy – sequence: 6 givenname: G.L. surname: Mancardi fullname: Mancardi, G.L. organization: Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy, Center for Excellence for Biomedical Research, University of Genova, Genova, Italy – sequence: 7 givenname: P.G. surname: Morasso fullname: Morasso, P.G. organization: Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy – sequence: 8 givenname: P. surname: Tanganelli fullname: Tanganelli, P. organization: Department of Neurology, Hospital 'P Antero Micone', Genova, Italy – sequence: 9 givenname: V. surname: Sanguineti fullname: Sanguineti, V. organization: Department of Informatics, Systems and Telematics, University of Genova, Genova, Italy |
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| Cites_doi | 10.1016/S0022-510X(99)00006-4 10.1016/S0165-0270(01)00373-9 10.1136/jnnp.66.1.43 10.1002/ana.1032 10.1212/WNL.56.10.1324 10.1002/ana.410130302 10.1038/nn963 10.1212/WNL.33.11.1444 10.1038/35000576 10.1016/S0167-9457(02)00159-8 10.1152/jn.1996.76.1.492 |
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| Keywords | upper limb asymptomatic multiple sclerosis sensorimotor control digitizing tablet Human Speed Multiple sclerosis Nervous system diseases Digitizing Asymptomatic Nuclear magnetic resonance imaging Hand Inflammatory disease Vision Central nervous system disease Strategy Tablet Degenerative disease Upper limb Performance Visual control |
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| References_xml | – volume: 163 start-page: 61 year: 1999 end-page: 69 article-title: Influence ofl visual and proprioceptive aflflerences on upper limb ataxia in patients with multiple sclerosis publication-title: J Neurol Sci – volume: 108 start-page: 25 year: 2001 end-page: 37 article-title: Measurement ofl ataxic symptoms with a graphic tablet: standard values in controls and validity in multiple sclerosis patients publication-title: J Neurosci Methods – volume: 50 start-page: 121 year: 2001 end-page: 27 article-title: Recommended diagnostic criteria flor multiple sclerosis: guidelines flrom the International Panel on the Diagnosis ofl Multiple Sclerosis publication-title: Ann Neurol – volume: 76 start-page: 492 year: 1996 end-page: 509 article-title: Cerebellar ataxia: abnormal control ofl interaction torques across multiple joints publication-title: J Neurophysiol – volume: 403 start-page: 544 year: 2000 end-page: 49 article-title: Motor disorder in Huntington's disease begins as a dysflunction in error fleedback control publication-title: Nature – volume: 66 start-page: 43 year: 1999 end-page: 47 article-title: Distal versus proximal arm tremor in multiple sclerosis assessed by visually guided tracking tasks publication-title: J Neurol Neurosurg Psychiatry – volume: 13 start-page: 227 year: 1983 end-page: 31 article-title: New diagnostic criteria flor multiple sclerosis: guidelines flor research protocols publication-title: Ann Neurol – volume: 56 start-page: 1324 year: 2001 end-page: 30 article-title: Use ofl the Multiple Sclerosis Functional Composite to predict disability in relapsing MS publication-title: Neurology – volume: 5 start-page: 1226 year: 2002 end-page: 35 article-title: Optimal fleedback control as a theory ofl motor coordination publication-title: Nat Neurosci – volume: 33 start-page: 1444 year: 1983 end-page: 52 article-title: Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS) publication-title: Neurology – volume: 22 start-page: 189 year: 2003 end-page: 205 article-title: Cerebellar ataxia: quantitative assessment and cybernetic interpretation publication-title: Hum Mov Sci – volume: 34 start-page: 136872 year: 1984 article-title: A neurologic rating scale (NRS) flor use in multiple sclerosis publication-title: Neurology – ident: atypb5 doi: 10.1016/S0022-510X(99)00006-4 – ident: atypb7 doi: 10.1016/S0165-0270(01)00373-9 – ident: atypb6 doi: 10.1136/jnnp.66.1.43 – ident: atypb8 doi: 10.1002/ana.1032 – ident: atypb11 doi: 10.1212/WNL.56.10.1324 – ident: atypb9 doi: 10.1002/ana.410130302 – volume: 34 start-page: 136872 year: 1984 ident: atypb10 publication-title: Neurology – ident: atypb12 doi: 10.1038/nn963 – ident: atypb1 doi: 10.1212/WNL.33.11.1444 – ident: atypb2 doi: 10.1038/35000576 – ident: atypb3 doi: 10.1016/S0167-9457(02)00159-8 – ident: atypb4 doi: 10.1152/jn.1996.76.1.492 |
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| SubjectTerms | Adult Age of Onset Arm Biological and medical sciences Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Demyelinating Diseases - physiopathology Demyelinating Diseases - psychology Humans Immunomodulators Magnetic Resonance Imaging Medical sciences Middle Aged Motor Activity Multiple Sclerosis - physiopathology Multiple Sclerosis - psychology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Pharmacology. Drug treatments Psychomotor Performance Reference Values |
| Title | Subtle upper limb impairment in asymptomatic multiple sclerosis subjects |
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