Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation

• Published in: International journal of molecular sciences Vol. 23; no. 21; p. 13477
• Main Authors: Lei, Lijuan, Chen, Minghua, Wang, Chenyin, Jiang, Xinhai, Li, Yinghong, Wang, Weizhi, Li, Shunwang, Zhao, Liping, Sheng, Ren, Han, Jiangxue, Zhang, Yuyan, Chen, Yuchuan, Yan, Biying, Wu, Yexiang, Yu, Liyan, Si, Shuyi, Xu, Yanni
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 03.11.2022; MDPI
• Subjects: Atherosclerosis; Cardiovascular disease; Cell adhesion & migration; Chromatography; Inflammation; NMR; Nuclear magnetic resonance; Proteins; Thrombosis; Transcription factors

Krüppel-like factor 2 (KLF2) is an atherosclerotic protective transcription factor that maintains endothelial cell homeostasis through its anti-inflammatory, anti-oxidant, and antithrombotic properties. The aim of this study was to discover KLF2 activators from microbial secondary metabolites and ex...