Lymph Node Subcapsular Sinus Macrophages as the Frontline of Lymphatic Immune Defense

• Published in: Frontiers in immunology Vol. 10; p. 347
• Main Authors: Louie, Dante Alexander Patrick, Liao, Shan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.02.2019
• Subjects: bacteria; CD169; free-floating antigens; Immunology; lymph node (LN); subcapsular sinus macrophage; virus; lymph node (LN); bacteria; subcapsular sinus macrophage; cancer; free-floating antigens; CD169; virus

Lymphatic vessels collect and transport lymph and pathogens to the draining lymph node (LN) to generate proper immune protection. A layer of macrophages that strategically line the LN subcapsular sinus (SCS) is directly exposed to the afferent lymph and are denoted as SCS macrophages. These macropha...