Asymmetry of frameshift mutagenesis during leading and lagging-strand replication in Escherichia coli

• Published in: Mutation research Vol. 501; no. 1-2; p. 129
• Main Authors: Gawel, Damian, Jonczyk, Piotr, Bialoskorska, Malgorzata, Schaaper, Roel M, Fijalkowska, Iwona J
• Format: Journal Article
• Language: English
• Published: Netherlands 25.04.2002
• Subjects: DNA Replication - genetics; Escherichia coli - genetics; Frameshift Mutation - genetics; Lac Operon - genetics; Mutagenesis

Mutations in DNA, including frameshifts, may arise during DNA replication as a result of mistakes made by the DNA polymerase in copying the DNA template strands. In our efforts to better understand the factors that contribute to the accuracy of DNA replication, we have investigated whether frameshif...