Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects
Compelling evidence supports the health benefits of physical exercise on the immune system, possibly through the molecules secreted by the skeletal muscles known as myokines. Herein, we assessed the impact of exercise interventions on plasma Heat shock protein 90 (Hsp90) levels in 27 patients with i...
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| Published in | International journal of molecular sciences Vol. 23; no. 19; p. 11451 |
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| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.10.2022
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| Online Access | Get full text |
| ISSN | 1422-0067 1661-6596 1422-0067 |
| DOI | 10.3390/ijms231911451 |
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| Abstract | Compelling evidence supports the health benefits of physical exercise on the immune system, possibly through the molecules secreted by the skeletal muscles known as myokines. Herein, we assessed the impact of exercise interventions on plasma Heat shock protein 90 (Hsp90) levels in 27 patients with idiopathic inflammatory myopathies (IIM) compared with 23 IIM patients treated with standard-of-care immunosuppressive therapy only, and in 18 healthy subjects undergoing strenuous eccentric exercise, and their associations with the traditional serum markers of muscle damage and inflammation. In contrast to IIM patients treated with pharmacotherapy only, in whom we demonstrated a significant decrease in Hsp90 over 24 weeks, the 24-week exercise program resulted in a stabilization of Hsp90 levels. These changes in Hsp90 levels were associated with changes in several inflammatory cytokines/chemokines involved in the pathogenesis of IIM or muscle regeneration in general. Strenuous eccentric exercise in healthy volunteers induced a brief increase in Hsp90 levels with a subsequent return to baseline levels at 14 days after the exercise, with less pronounced correlations to systemic inflammation. In this study, we identified Hsp90 as a potential myokine and mediator for exercise-induced immune response and as a potential biomarker predicting improvement after physiotherapy in muscle endurance in IIM. |
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| AbstractList | Compelling evidence supports the health benefits of physical exercise on the immune system, possibly through the molecules secreted by the skeletal muscles known as myokines. Herein, we assessed the impact of exercise interventions on plasma Heat shock protein 90 (Hsp90) levels in 27 patients with idiopathic inflammatory myopathies (IIM) compared with 23 IIM patients treated with standard-of-care immunosuppressive therapy only, and in 18 healthy subjects undergoing strenuous eccentric exercise, and their associations with the traditional serum markers of muscle damage and inflammation. In contrast to IIM patients treated with pharmacotherapy only, in whom we demonstrated a significant decrease in Hsp90 over 24 weeks, the 24-week exercise program resulted in a stabilization of Hsp90 levels. These changes in Hsp90 levels were associated with changes in several inflammatory cytokines/chemokines involved in the pathogenesis of IIM or muscle regeneration in general. Strenuous eccentric exercise in healthy volunteers induced a brief increase in Hsp90 levels with a subsequent return to baseline levels at 14 days after the exercise, with less pronounced correlations to systemic inflammation. In this study, we identified Hsp90 as a potential myokine and mediator for exercise-induced immune response and as a potential biomarker predicting improvement after physiotherapy in muscle endurance in IIM.Compelling evidence supports the health benefits of physical exercise on the immune system, possibly through the molecules secreted by the skeletal muscles known as myokines. Herein, we assessed the impact of exercise interventions on plasma Heat shock protein 90 (Hsp90) levels in 27 patients with idiopathic inflammatory myopathies (IIM) compared with 23 IIM patients treated with standard-of-care immunosuppressive therapy only, and in 18 healthy subjects undergoing strenuous eccentric exercise, and their associations with the traditional serum markers of muscle damage and inflammation. In contrast to IIM patients treated with pharmacotherapy only, in whom we demonstrated a significant decrease in Hsp90 over 24 weeks, the 24-week exercise program resulted in a stabilization of Hsp90 levels. These changes in Hsp90 levels were associated with changes in several inflammatory cytokines/chemokines involved in the pathogenesis of IIM or muscle regeneration in general. Strenuous eccentric exercise in healthy volunteers induced a brief increase in Hsp90 levels with a subsequent return to baseline levels at 14 days after the exercise, with less pronounced correlations to systemic inflammation. In this study, we identified Hsp90 as a potential myokine and mediator for exercise-induced immune response and as a potential biomarker predicting improvement after physiotherapy in muscle endurance in IIM. Compelling evidence supports the health benefits of physical exercise on the immune system, possibly through the molecules secreted by the skeletal muscles known as myokines. Herein, we assessed the impact of exercise interventions on plasma Heat shock protein 90 (Hsp90) levels in 27 patients with idiopathic inflammatory myopathies (IIM) compared with 23 IIM patients treated with standard-of-care immunosuppressive therapy only, and in 18 healthy subjects undergoing strenuous eccentric exercise, and their associations with the traditional serum markers of muscle damage and inflammation. In contrast to IIM patients treated with pharmacotherapy only, in whom we demonstrated a significant decrease in Hsp90 over 24 weeks, the 24-week exercise program resulted in a stabilization of Hsp90 levels. These changes in Hsp90 levels were associated with changes in several inflammatory cytokines/chemokines involved in the pathogenesis of IIM or muscle regeneration in general. Strenuous eccentric exercise in healthy volunteers induced a brief increase in Hsp90 levels with a subsequent return to baseline levels at 14 days after the exercise, with less pronounced correlations to systemic inflammation. In this study, we identified Hsp90 as a potential myokine and mediator for exercise-induced immune response and as a potential biomarker predicting improvement after physiotherapy in muscle endurance in IIM. |
| Author | Zámečník, Josef Štorkánová, Hana Špiritović, Maja Heřmánková, Barbora Česák, Petr Slabý, Kryštof Bubová, Kristýna Khouri, Haya Tomčík, Michal Švec, Xiao Pekáčová, Aneta Mann, Heřman Komarc, Martin Amjad, Gulalai Pavelka, Karel Vencovský, Jiří Šenolt, Ladislav Oreská, Sabína |
| AuthorAffiliation | 6 Department of Human Movement Laboratory, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic 4 Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic 3 Department of Rheumatology, 1st Faculty of Medicine, Charles University, 128 50 Prague, Czech Republic 1 Institute of Rheumatology, 128 00 Prague, Czech Republic 5 Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic 2 1st Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic 7 Department of Methodology, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic 8 Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic |
| AuthorAffiliation_xml | – name: 2 1st Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic – name: 1 Institute of Rheumatology, 128 00 Prague, Czech Republic – name: 7 Department of Methodology, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic – name: 5 Department of Rehabilitation and Sports Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic – name: 6 Department of Human Movement Laboratory, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic – name: 8 Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University, University Hospital Motol, 150 06 Prague, Czech Republic – name: 3 Department of Rheumatology, 1st Faculty of Medicine, Charles University, 128 50 Prague, Czech Republic – name: 4 Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic |
| Author_xml | – sequence: 1 givenname: Xiao orcidid: 0000-0001-5700-9055 surname: Švec fullname: Švec, Xiao – sequence: 2 givenname: Hana surname: Štorkánová fullname: Štorkánová, Hana – sequence: 3 givenname: Maja surname: Špiritović fullname: Špiritović, Maja – sequence: 4 givenname: Kryštof surname: Slabý fullname: Slabý, Kryštof – sequence: 5 givenname: Sabína orcidid: 0000-0002-9912-725X surname: Oreská fullname: Oreská, Sabína – sequence: 6 givenname: Aneta orcidid: 0000-0002-8947-5955 surname: Pekáčová fullname: Pekáčová, Aneta – sequence: 7 givenname: Barbora surname: Heřmánková fullname: Heřmánková, Barbora – sequence: 8 givenname: Kristýna surname: Bubová fullname: Bubová, Kristýna – sequence: 9 givenname: Petr surname: Česák fullname: Česák, Petr – sequence: 10 givenname: Haya surname: Khouri fullname: Khouri, Haya – sequence: 11 givenname: Gulalai surname: Amjad fullname: Amjad, Gulalai – sequence: 12 givenname: Heřman surname: Mann fullname: Mann, Heřman – sequence: 13 givenname: Martin orcidid: 0000-0003-4106-5217 surname: Komarc fullname: Komarc, Martin – sequence: 14 givenname: Karel surname: Pavelka fullname: Pavelka, Karel – sequence: 15 givenname: Ladislav surname: Šenolt fullname: Šenolt, Ladislav – sequence: 16 givenname: Josef surname: Zámečník fullname: Zámečník, Josef – sequence: 17 givenname: Jiří surname: Vencovský fullname: Vencovský, Jiří – sequence: 18 givenname: Michal orcidid: 0000-0002-8616-7850 surname: Tomčík fullname: Tomčík, Michal |
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| Cites_doi | 10.1249/MSS.0000000000002628 10.1515/CCLM.2006.179 10.4314/ahs.v19i2.45 10.1073/pnas.85.11.3850 10.1152/physrev.2000.80.3.1055 10.1007/s10067-019-04571-9 10.1016/j.apmr.2016.09.125 10.3389/fphys.2019.00086 10.1186/s13075-021-02544-5 10.18632/oncotarget.12411 10.1016/j.ehj.2003.12.006 10.1016/j.biopsycho.2018.01.015 10.1080/00365510802126844 10.1007/978-3-030-02254-9_5 10.1111/1346-8138.14518 10.3389/fphys.2020.567881 10.3389/fimmu.2022.811045 10.1007/978-3-030-02254-9_12 10.1038/s41572-021-00321-x 10.4161/adip.20344 10.1038/nrrheum.2018.48 10.1097/BOR.0b013e3283317b31 10.1210/endrev/bnaa016 10.1186/s42358-018-0018-8 10.1007/s004010051041 10.1016/j.bbadis.2020.165823 10.1042/BCJ20160005 10.1097/BOR.0b013e3283319d53 10.1016/j.berh.2020.101504 10.1007/978-3-319-11251-0_24 10.1007/s10067-009-1316-7 10.1007/s00421-005-0035-2 10.1038/s41574-022-00641-2 10.1007/s12192-016-0670-z 10.1186/s40001-019-0368-7 10.4049/jimmunol.164.12.6593 10.1111/imj.15358 10.1212/WNL.58.12.1779 10.1155/2014/627150 10.1111/apha.13367 10.1007/978-981-15-1792-1_27 10.1152/japplphysiol.00164.2004 10.1186/s13075-014-0473-5 10.1515/CCLM.2010.179 10.1016/j.berh.2020.101547 10.1038/nrrheum.2014.193 10.1016/j.rdc.2019.07.006 10.1097/BOR.0000000000000744 10.1002/cphy.c120033 10.1016/j.bbi.2011.02.010 10.1007/s13105-010-0052-4 10.1152/japplphysiol.00811.2015 10.1007/978-3-030-03952-3 10.3390/cancers12010021 10.3389/fphys.2019.00536 10.1111/eci.12781 10.1080/10408363.2021.2000584 10.1007/978-3-030-02254-9_8 10.1002/mus.23317 10.1177/1099800420958068 10.1016/j.nmd.2011.07.007 10.14814/phy2.14552 10.1097/00003246-200210000-00006 10.1046/j.1365-201X.2002.00979.x 10.1016/j.cyto.2018.10.020 10.1007/s10067-020-05339-2 10.1046/j.1365-2567.1999.00773.x 10.1152/japplphysiol.01052.2018 10.1007/s00125-019-4927-9 10.1016/j.mayocp.2012.10.017 10.1097/BOR.0000000000000829 10.1023/A:1026070911202 10.1074/jbc.274.3.1723 10.1007/s00296-020-04735-w 10.21873/invivo.11108 10.3389/fnagi.2019.00098 10.1111/j.1749-6632.2009.04812.x |
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| References | Miller (ref_21) 2018; 14 Ernste (ref_26) 2013; 88 Alexanderson (ref_23) 2019; 45 Peake (ref_79) 2005; 95 Paolucci (ref_69) 2018; 133 Ashton (ref_24) 2021; 51 Liprandi (ref_38) 1999; 97 Stephanou (ref_42) 1999; 7 Lappalainen (ref_59) 2002; 30 Wang (ref_12) 2020; 1228 Tukaj (ref_45) 2016; 21 Wu (ref_39) 2019; 24 Benatti (ref_28) 2015; 11 Pedersen (ref_4) 2017; 47 Stephanou (ref_43) 1999; 274 Chow (ref_9) 2022; 18 Ripley (ref_56) 1999; 97 (ref_49) 2019; 19 Bay (ref_13) 2020; 11 Hody (ref_32) 2019; 10 Prodromou (ref_44) 2016; 473 Tiffreau (ref_76) 2017; 98 Lippi (ref_58) 2008; 68 Shastry (ref_61) 2002; 175 Severinsen (ref_2) 2020; 41 Silva (ref_35) 2018; 58 Kim (ref_66) 2010; 29 Alexanderson (ref_74) 2020; 34 Eckel (ref_1) 2019; 62 Creus (ref_33) 2009; 21 Klein (ref_31) 2021; 23 McGarr (ref_15) 2020; 8 Asea (ref_14) 2019; Volume 16 Leers (ref_57) 2006; 44 Nader (ref_30) 2009; 21 Zheng (ref_52) 2019; 11 Vulsteke (ref_73) 2019; 38 Asea (ref_19) 2019; Volume 16 Asea (ref_18) 2019; Volume 16 Niyazi (ref_51) 2021; 23 Cronin (ref_71) 2017; 110 Mann (ref_20) 2022; 13 Bai (ref_40) 2021; 40 Pedersen (ref_6) 2003; 24 Lundberg (ref_22) 2021; 7 Creus (ref_62) 2009; 1173 Pedersen (ref_5) 2011; 25 Tsamis (ref_25) 2022; 59 Paepe (ref_63) 2012; 22 Ferris (ref_54) 1988; 85 Misse (ref_29) 2021; 33 Sag (ref_68) 2021; 41 Vanwalleghem (ref_78) 2002; 58 Das (ref_10) 2020; 228 Claudi (ref_65) 2004; 25 Metsios (ref_27) 2020; 34 Oishi (ref_36) 2018; 45 Sugiura (ref_37) 2000; 164 Pedersen (ref_3) 2012; 1 Baturcam (ref_50) 2014; 2014 Scheffer (ref_11) 2020; 1866 Fritsch (ref_41) 2016; 7 ref_47 Luk (ref_77) 2021; 53 ref_46 Isaacs (ref_64) 2019; 10 Reichel (ref_17) 2019; 126 Barabutis (ref_55) 2019; 113 Mattar (ref_75) 2014; 16 Henstridge (ref_16) 2016; 120 Pedersen (ref_70) 2000; 80 Pedersen (ref_8) 2013; 3 Bote (ref_72) 2011; 67 Yetimler (ref_67) 2017; 31 Petersen (ref_48) 2005; 98 Brancaccio (ref_60) 2010; 48 Mathers (ref_53) 2012; 46 Cerezo (ref_34) 2020; 32 ref_7 |
| References_xml | – volume: 53 start-page: 1595 year: 2021 ident: ref_77 article-title: Sex Dimorphism in Muscle Damage-Induced Inflammation publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0000000000002628 – volume: 44 start-page: 999 year: 2006 ident: ref_57 article-title: Effects of a Long-Distance Run on Cardiac Markers in Healthy Athletes publication-title: Clin. Chem. Lab. Med. doi: 10.1515/CCLM.2006.179 – volume: 19 start-page: 2198 year: 2019 ident: ref_49 article-title: Aerobic Exercise Modulates Cytokine Profile and Sleep Quality in Elderly publication-title: Afr. Health Sci. doi: 10.4314/ahs.v19i2.45 – volume: 85 start-page: 3850 year: 1988 ident: ref_54 article-title: Mitogen and Lymphokine Stimulation of Heat Shock Proteins in T Lymphocytes publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.85.11.3850 – volume: 80 start-page: 1055 year: 2000 ident: ref_70 article-title: Exercise and the Immune System: Regulation, Integration, and Adaptation publication-title: Physiol. Rev. doi: 10.1152/physrev.2000.80.3.1055 – volume: 38 start-page: 2039 year: 2019 ident: ref_73 article-title: Physical Therapy in Adult Inflammatory Myopathy Patients: A Systematic Review publication-title: Clin. Rheumatol. doi: 10.1007/s10067-019-04571-9 – volume: 98 start-page: 227 year: 2017 ident: ref_76 article-title: Postrehabilitation Functional Improvements in Patients With Inflammatory Myopathies: The Results of a Randomized Controlled Trial publication-title: Arch. Phys. Med. Rehabil. doi: 10.1016/j.apmr.2016.09.125 – volume: 10 start-page: 86 year: 2019 ident: ref_64 article-title: C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise publication-title: Front. Physiol. doi: 10.3389/fphys.2019.00086 – volume: 23 start-page: 173 year: 2021 ident: ref_31 article-title: The Effect of a 24-Week Training Focused on Activities of Daily Living, Muscle Strengthening, and Stability in Idiopathic Inflammatory Myopathies: A Monocentric Controlled Study with Follow-Up publication-title: Arthritis Res. Ther. doi: 10.1186/s13075-021-02544-5 – volume: 7 start-page: 75774 year: 2016 ident: ref_41 article-title: TNF Induced Cleavage of HSP90 by Cathepsin D Potentiates Apoptotic Cell Death publication-title: Oncotarget doi: 10.18632/oncotarget.12411 – volume: 25 start-page: 349 year: 2004 ident: ref_65 article-title: Exercise Reduces Plasma Levels of the Chemokines MCP-1 and IL-8 in Subjects with the Metabolic Syndrome publication-title: Eur. Heart J. doi: 10.1016/j.ehj.2003.12.006 – volume: 133 start-page: 79 year: 2018 ident: ref_69 article-title: Exercise Reduces Depression and Inflammation but Intensity Matters publication-title: Biol. Psychol. doi: 10.1016/j.biopsycho.2018.01.015 – volume: 68 start-page: 667 year: 2008 ident: ref_58 article-title: Acute Variation of Biochemical Markers of Muscle Damage Following a 21-Km, Half-Marathon Run publication-title: Scand. J. Clin. Lab. Investig. doi: 10.1080/00365510802126844 – volume: Volume 16 start-page: 105 year: 2019 ident: ref_19 article-title: Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases publication-title: Chaperokine Activity of Heat Shock Proteins doi: 10.1007/978-3-030-02254-9_5 – volume: 45 start-page: 1023 year: 2018 ident: ref_36 article-title: Increased Interleukin-9 Levels in Sera, Muscle and Skin of Patients with Dermatomyositis publication-title: J. Dermatol. doi: 10.1111/1346-8138.14518 – volume: 11 start-page: 567881 year: 2020 ident: ref_13 article-title: Muscle-Organ Crosstalk: Focus on Immunometabolism publication-title: Front. Physiol. doi: 10.3389/fphys.2020.567881 – volume: 13 start-page: 811045 year: 2022 ident: ref_20 article-title: Hsp90 Levels in Idiopathic Inflammatory Myopathies and Their Association With Muscle Involvement and Disease Activity: A Cross-Sectional and Longitudinal Study publication-title: Front. Immunol. doi: 10.3389/fimmu.2022.811045 – volume: Volume 16 start-page: 247 year: 2019 ident: ref_14 article-title: Physical Exercise and Heat Shock Proteins publication-title: Chaperokine Activity of Heat Shock Proteins doi: 10.1007/978-3-030-02254-9_12 – volume: 7 start-page: 86 year: 2021 ident: ref_22 article-title: Idiopathic Inflammatory Myopathies publication-title: Nat. Rev. Dis. Primers doi: 10.1038/s41572-021-00321-x – volume: 1 start-page: 164 year: 2012 ident: ref_3 article-title: Muscle-to-Organ Cross Talk Mediated by Myokines publication-title: Adipocyte doi: 10.4161/adip.20344 – volume: 14 start-page: 255 year: 2018 ident: ref_21 article-title: Risk Factors and Disease Mechanisms in Myositis publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2018.48 – volume: 21 start-page: 610 year: 2009 ident: ref_33 article-title: Role of Cytokines and Chemokines in Idiopathic Inflammatory Myopathies publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0b013e3283317b31 – volume: 41 start-page: bnaa016 year: 2020 ident: ref_2 article-title: Muscle-Organ Crosstalk: The Emerging Roles of Myokines publication-title: Endocr. Rev. doi: 10.1210/endrev/bnaa016 – volume: 58 start-page: 17 year: 2018 ident: ref_35 article-title: Relevance of Serum Angiogenic Cytokines in Adult Patients with Dermatomyositis publication-title: Adv. Rheumatol. doi: 10.1186/s42358-018-0018-8 – volume: 97 start-page: 642 year: 1999 ident: ref_38 article-title: Local Expression of Monocyte Chemoattractant Protein-1 (MCP-1) in Idiopathic Inflammatory Myopathies publication-title: Acta Neuropathol. doi: 10.1007/s004010051041 – volume: 1866 start-page: 165823 year: 2020 ident: ref_11 article-title: Exercise-Induced Immune System Response: Anti-Inflammatory Status on Peripheral and Central Organs publication-title: Biochim. Biophys. Acta Mol. Basis Dis. doi: 10.1016/j.bbadis.2020.165823 – volume: 473 start-page: 2439 year: 2016 ident: ref_44 article-title: Mechanisms of Hsp90 Regulation publication-title: Biochem. J. doi: 10.1042/BCJ20160005 – volume: 21 start-page: 599 year: 2009 ident: ref_30 article-title: Exercise as an Anti-Inflammatory Intervention to Combat Inflammatory Diseases of Muscle publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0b013e3283319d53 – volume: 34 start-page: 101504 year: 2020 ident: ref_27 article-title: Exercise and Inflammation publication-title: Best Pract. Res. Clin. Rheumatol. doi: 10.1016/j.berh.2020.101504 – ident: ref_7 doi: 10.1007/978-3-319-11251-0_24 – volume: 29 start-page: 273 year: 2010 ident: ref_66 article-title: Expression of TLR2, TLR4, and TLR9 in Dermatomyositis and Polymyositis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-009-1316-7 – volume: 95 start-page: 514 year: 2005 ident: ref_79 article-title: Plasma Cytokine Changes in Relation to Exercise Intensity and Muscle Damage publication-title: Eur. J. Appl. Physiol. doi: 10.1007/s00421-005-0035-2 – volume: 18 start-page: 273 year: 2022 ident: ref_9 article-title: Exerkines in Health, Resilience and Disease publication-title: Nat. Rev. Endocrinol. doi: 10.1038/s41574-022-00641-2 – volume: 21 start-page: 213 year: 2016 ident: ref_45 article-title: Anti-Hsp90 Therapy in Autoimmune and Inflammatory Diseases:A Review of Preclinical Studies publication-title: Cell Stress Chaperones doi: 10.1007/s12192-016-0670-z – volume: 110 start-page: 629 year: 2017 ident: ref_71 article-title: The Effect of Exercise Interventions on Inflammatory Biomarkers in Healthy, Physically Inactive Subjects: A Systematic Review publication-title: QJM – volume: 24 start-page: 12 year: 2019 ident: ref_39 article-title: Detection of Serum MCP-1 and TGF-Β1 in Polymyositis/Dermatomyositis Patients and Its Significance publication-title: Eur. J. Med. Res. doi: 10.1186/s40001-019-0368-7 – volume: 164 start-page: 6593 year: 2000 ident: ref_37 article-title: Increased CD40 Expression on Muscle Cells of Polymyositis and Dermatomyositis: Role of CD40-CD40 Ligand Interaction in IL-6, IL-8, IL-15, and Monocyte Chemoattractant Protein-1 Production publication-title: J. Immunol. doi: 10.4049/jimmunol.164.12.6593 – volume: 51 start-page: 845 year: 2021 ident: ref_24 article-title: Idiopathic Inflammatory Myopathies: A Review publication-title: Intern. Med. J. doi: 10.1111/imj.15358 – volume: 58 start-page: 1779 year: 2002 ident: ref_78 article-title: Differential Expression of Chemokines in Inflammatory Myopathies publication-title: Neurology doi: 10.1212/WNL.58.12.1779 – volume: 2014 start-page: 627150 year: 2014 ident: ref_50 article-title: Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans publication-title: Mediat. Inflamm. doi: 10.1155/2014/627150 – volume: 228 start-page: e13367 year: 2020 ident: ref_10 article-title: Myokines in Skeletal Muscle Physiology and Metabolism: Recent Advances and Future Perspectives publication-title: Acta Physiol. doi: 10.1111/apha.13367 – volume: 1228 start-page: 395 year: 2020 ident: ref_12 article-title: Exercise Regulates the Immune System publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-981-15-1792-1_27 – volume: 98 start-page: 1154 year: 2005 ident: ref_48 article-title: The Anti-Inflammatory Effect of Exercise publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00164.2004 – volume: 16 start-page: 473 year: 2014 ident: ref_75 article-title: Safety and Possible Effects of Low-Intensity Resistance Training Associated with Partial Blood Flow Restriction in Polymyositis and Dermatomyositis publication-title: Arthritis Res. Ther. doi: 10.1186/s13075-014-0473-5 – volume: 48 start-page: 757 year: 2010 ident: ref_60 article-title: Biochemical Markers of Muscular Damage publication-title: Clin. Chem. Lab. Med. doi: 10.1515/CCLM.2010.179 – volume: 34 start-page: 101547 year: 2020 ident: ref_74 article-title: Exercise Therapy in Patients with Idiopathic Inflammatory Myopathies and Systemic Lupus Erythematosus—A Systematic Literature Review publication-title: Best Pract. Res. Clin. Rheumatol. doi: 10.1016/j.berh.2020.101547 – volume: 11 start-page: 86 year: 2015 ident: ref_28 article-title: Exercise as an Anti-Inflammatory Therapy for Rheumatic Diseases-Myokine Regulation publication-title: Nat. Rev. Rheumatol. doi: 10.1038/nrrheum.2014.193 – volume: 45 start-page: 569 year: 2019 ident: ref_23 article-title: Idiopathic Inflammatory Myopathies publication-title: Rheum. Dis. Clin. N. Am. doi: 10.1016/j.rdc.2019.07.006 – volume: 32 start-page: 534 year: 2020 ident: ref_34 article-title: Cytokines and Inflammatory Mediators as Promising Markers of Polymyositis/Dermatomyositis publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0000000000000744 – volume: 3 start-page: 1337 year: 2013 ident: ref_8 article-title: Muscle as a Secretory Organ publication-title: Compr. Physiol. doi: 10.1002/cphy.c120033 – volume: 25 start-page: 811 year: 2011 ident: ref_5 article-title: Exercise-Induced Myokines and Their Role in Chronic Diseases publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2011.02.010 – volume: 67 start-page: 87 year: 2011 ident: ref_72 article-title: A Single Session of Intense Exercise Improves the Inflammatory Response in Healthy Sedentary Women publication-title: J. Physiol. Biochem. doi: 10.1007/s13105-010-0052-4 – volume: 120 start-page: 683 year: 2016 ident: ref_16 article-title: Heat Shock Proteins and Exercise Adaptations. Our Knowledge Thus Far and the Road Still Ahead publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.00811.2015 – ident: ref_46 doi: 10.1007/978-3-030-03952-3 – ident: ref_47 doi: 10.3390/cancers12010021 – volume: 10 start-page: 536 year: 2019 ident: ref_32 article-title: Eccentric Muscle Contractions: Risks and Benefits publication-title: Front. Physiol. doi: 10.3389/fphys.2019.00536 – volume: 47 start-page: 600 year: 2017 ident: ref_4 article-title: Anti-Inflammatory Effects of Exercise: Role in Diabetes and Cardiovascular Disease publication-title: Eur. J. Clin. Investig. doi: 10.1111/eci.12781 – volume: 59 start-page: 219 year: 2022 ident: ref_25 article-title: Clinical Features and Diagnostic Tools in Idiopathic Inflammatory Myopathies publication-title: Crit. Rev. Clin. Lab. Sci. doi: 10.1080/10408363.2021.2000584 – volume: Volume 16 start-page: 155 year: 2019 ident: ref_18 article-title: Chaperones in Sterile Inflammation and Injury publication-title: Chaperokine Activity of Heat Shock Proteins doi: 10.1007/978-3-030-02254-9_8 – volume: 46 start-page: 407 year: 2012 ident: ref_53 article-title: Early Inflammatory and Myogenic Responses to Resistance Exercise in the Elderly publication-title: Muscle Nerve doi: 10.1002/mus.23317 – volume: 23 start-page: 280 year: 2021 ident: ref_51 article-title: Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis publication-title: Biol. Res. Nurs. doi: 10.1177/1099800420958068 – volume: 22 start-page: 26 year: 2012 ident: ref_63 article-title: Heat Shock Protein Families 70 and 90 in Duchenne Muscular Dystrophy and Inflammatory Myopathy: Balancing Muscle Protection and Destruction publication-title: Neuromuscul. Disord. doi: 10.1016/j.nmd.2011.07.007 – volume: 8 start-page: e14552 year: 2020 ident: ref_15 article-title: Heat Shock Protein 90 Modulates Cutaneous Vasodilation during an Exercise-Heat Stress, but Not during Passive Whole-Body Heating in Young Women publication-title: Physiol. Rep. doi: 10.14814/phy2.14552 – volume: 30 start-page: 2212 year: 2002 ident: ref_59 article-title: Elimination Kinetics of Myoglobin and Creatine Kinase in Rhabdomyolysis: Implications for Follow-Up publication-title: Crit. Care Med. doi: 10.1097/00003246-200210000-00006 – volume: 175 start-page: 139 year: 2002 ident: ref_61 article-title: HSP70 and HSP90 Expression in Leucocytes after Exercise in Moderately Trained Humans publication-title: Acta Physiol. Scand. doi: 10.1046/j.1365-201X.2002.00979.x – volume: 113 start-page: 427 year: 2019 ident: ref_55 article-title: Hsp90 Inhibitors Suppress P53 Phosphorylation in LPS-Induced Endothelial Inflammation publication-title: Cytokine doi: 10.1016/j.cyto.2018.10.020 – volume: 40 start-page: 999 year: 2021 ident: ref_40 article-title: Hierarchical Cluster Analysis of Cytokine Profiles Reveals a Cutaneous Vasculitis-Associated Subgroup in Dermatomyositis publication-title: Clin. Rheumatol. doi: 10.1007/s10067-020-05339-2 – volume: 97 start-page: 226 year: 1999 ident: ref_56 article-title: Interleukin-10 Activates Heat-Shock Protein 90beta Gene Expression publication-title: Immunology doi: 10.1046/j.1365-2567.1999.00773.x – volume: 126 start-page: 916 year: 2019 ident: ref_17 article-title: Role of Heat Shock Proteins 70/90 in Exercise Physiology and Exercise Immunology and Their Diagnostic Potential in Sports publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.01052.2018 – volume: 62 start-page: 1523 year: 2019 ident: ref_1 article-title: Myokines in Metabolic Homeostasis and Diabetes publication-title: Diabetologia doi: 10.1007/s00125-019-4927-9 – volume: 88 start-page: 83 year: 2013 ident: ref_26 article-title: Idiopathic Inflammatory Myopathies: Current Trends in Pathogenesis, Clinical Features, and up-to-Date Treatment Recommendations publication-title: Mayo Clin. Proc. doi: 10.1016/j.mayocp.2012.10.017 – volume: 33 start-page: 563 year: 2021 ident: ref_29 article-title: Physical Exercise for the Management of Systemic Autoimmune Myopathies: Recent Findings, and Future Perspectives publication-title: Curr. Opin. Rheumatol. doi: 10.1097/BOR.0000000000000829 – volume: 24 start-page: 113 year: 2003 ident: ref_6 article-title: Searching for the Exercise Factor: Is IL-6 a Candidate? publication-title: J. Muscle Res. Cell Motil. doi: 10.1023/A:1026070911202 – volume: 274 start-page: 1723 year: 1999 ident: ref_43 article-title: Signal Transducer and Activator of Transcription-1 and Heat ShockFactor-1 Interact and Activate the Transcription of the Hsp-70 and Hsp-90b Gene Promoters publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.3.1723 – volume: 7 start-page: 311 year: 1999 ident: ref_42 article-title: Transcriptional Regulation of the Heat Shock Protein Genes by STAT Family Transcription Factors publication-title: Gene Expr. – volume: 41 start-page: 77 year: 2021 ident: ref_68 article-title: Inflammatory Milieu of Muscle Biopsies in Juvenile Dermatomyositis publication-title: Rheumatol. Int. doi: 10.1007/s00296-020-04735-w – volume: 31 start-page: 657 year: 2017 ident: ref_67 article-title: Elevated IL-4 and IFN-γ Levels in Muscle Tissue of Patients with Dermatomyositis publication-title: In Vivo doi: 10.21873/invivo.11108 – volume: 11 start-page: 98 year: 2019 ident: ref_52 article-title: Effect of Aerobic Exercise on Inflammatory Markers in Healthy Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2019.00098 – volume: 1173 start-page: 463 year: 2009 ident: ref_62 article-title: A Dual Role for HSP90 and HSP70 in the Inflammatory Myopathies: From Muscle Fiber Protection to Active Invasion by Macrophages publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2009.04812.x |
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| Title | Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects |
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