The human nervous tissue in proximity to granulomatous lesions induced by Taenia solium metacestodes displays an active response

In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium metacestode. In this study, a histological and immunohistochemical analysis of five brain specimens from patients with neurocysticercosis reveal...

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Published inJournal of neuroimmunology Vol. 127; no. 1; pp. 139 - 144
Main Authors Alvarez, J.I., Colegial, C.H., Castaño, C.A., Trujillo, J., Teale, J.M., Restrepo, B.I.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2002
Subjects
Animals
Astrocytes - parasitology
Astrocytoma
Blood-Brain Barrier - immunology
Brain Chemistry - immunology
Cytokines - analysis
Fibroblast Growth Factor 2 - analysis
Humans
Immunohistochemistry
Immunology
Macrophages - parasitology
Mast cells
Mast Cells - pathology
Microglia - parasitology
Neurocysticercosis
Neurocysticercosis - immunology
Neurocysticercosis - pathology
Taenia - immunology
Taenia solium
Th1 Cells - immunology
Th2 Cells - immunology
Immunohistochemistry
Mast cells
Neurocysticercosis
Immunology
Taenia solium
Astrocytoma
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Abstract In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium metacestode. In this study, a histological and immunohistochemical analysis of five brain specimens from patients with neurocysticercosis revealed a proinflammatory activity reflected by an apparently altered blood–brain barrier permeability, secretion of pro-inflammatory cytokines, and up-regulation of molecules associated with antigen presentation. There were also anti-inflammatory cytokines, as well as an active wound-healing process reflected by angiogenesis, collagen deposition and glial scar formation. This immune response displayed by the nervous tissue adjacent to chronic neurocysticercosis lesions appeared to be contributing to the local tissue damage, and hence, may be fundamental in the pathology of NCC.
AbstractList In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium metacestode. In this study, a histological and immunohistochemical analysis of five brain specimens from patients with neurocysticercosis revealed a proinflammatory activity reflected by an apparently altered blood-brain barrier permeability, secretion of pro-inflammatory cytokines, and up-regulation of molecules associated with antigen presentation. There were also anti-inflammatory cytokines, as well as an active wound-healing process reflected by angiogenesis, collagen deposition and glial scar formation. This immune response displayed by the nervous tissue adjacent to chronic neurocysticercosis lesions appeared to be contributing to the local tissue damage, and hence, may be fundamental in the pathology of NCC.
In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium metacestode. In this study, a histological and immunohistochemical analysis of five brain specimens from patients with neurocysticercosis revealed a proinflammatory activity reflected by an apparently altered blood–brain barrier permeability, secretion of pro-inflammatory cytokines, and up-regulation of molecules associated with antigen presentation. There were also anti-inflammatory cytokines, as well as an active wound-healing process reflected by angiogenesis, collagen deposition and glial scar formation. This immune response displayed by the nervous tissue adjacent to chronic neurocysticercosis lesions appeared to be contributing to the local tissue damage, and hence, may be fundamental in the pathology of NCC.
Author Trujillo, J.
Alvarez, J.I.
Teale, J.M.
Castaño, C.A.
Colegial, C.H.
Restrepo, B.I.
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Keywords Immunohistochemistry
Mast cells
Neurocysticercosis
Immunology
Taenia solium
Astrocytoma
Language English
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Snippet In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium...
In neurocysticercosis, the nervous tissue surrounding the brain lesion is affected as a consequence of the local immune response induced by a Taenia solium...
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StartPage 139
SubjectTerms Animals
Astrocytes - parasitology
Astrocytoma
Blood-Brain Barrier - immunology
Brain Chemistry - immunology
Cytokines - analysis
Fibroblast Growth Factor 2 - analysis
Humans
Immunohistochemistry
Immunology
Macrophages - parasitology
Mast cells
Mast Cells - pathology
Microglia - parasitology
Neurocysticercosis
Neurocysticercosis - immunology
Neurocysticercosis - pathology
Taenia - immunology
Taenia solium
Th1 Cells - immunology
Th2 Cells - immunology
Title The human nervous tissue in proximity to granulomatous lesions induced by Taenia solium metacestodes displays an active response
URI https://dx.doi.org/10.1016/S0165-5728(02)00101-7
https://www.ncbi.nlm.nih.gov/pubmed/12044985
https://search.proquest.com/docview/18588436
https://search.proquest.com/docview/71780884
Volume 127
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