Influence of directional positive Darwinian selection-driven evolution on arboviruses Dengue and Zika virulence and pathogenesis

• Published in: Molecular phylogenetics and evolution Vol. 140; p. 106607
• Main Authors: Durães-Carvalho, Ricardo, Ludwig-Begall, Louisa F., Salemi, Marco, Lins, Roberto D., Marques, Ernesto T.A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019
• Subjects: Arbovirus; arboviruses; Bayes Theorem; Bayesian theory; Biological Evolution; Codon - genetics; codons; cross immunity; data collection; dengue; Dengue - virology; Dengue Virus - genetics; Dengue Virus - pathogenicity; glycosylation; hosts; Humans; Likelihood Functions; North America; Pathogenesis; pathogens; phosphorylation; Phylogeny; polyproteins; prediction; Selection, Genetic; Selection-driven evolution; South America; Virulence; virus transmission; Zika Virus - genetics; Zika Virus - pathogenicity; Zika Virus Infection - virology; South America; North America; Arbovirus; Pathogenesis; Virulence; Selection-driven evolution

[Display omitted] •DENV and ZIKV evolution are driven essentially by directional positive selection.•DENV and ZIKV polyproteins are under an intense directional evolution pressure.•We mapped mutations associated to changes in DENV and ZIKV virulence and pathogenesis.•The impact of certain mutations...