PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy

Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because...

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Published inFrontiers in pharmacology Vol. 10; p. 808
Main Authors Li, Yanping, Zhang, Ting, Liu, Qinhui, He, Jinhan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.07.2019
Subjects
cancer immunochemotherapy
cancer therapy
drug loading capacity
dual-functional nanomicelles
multidrug resistance
Pharmacology
polyethylene glycol (PEG)
cancer immunochemotherapy
cancer therapy
multidrug resistance
dual-functional nanomicelles
polyethylene glycol (PEG)
drug loading capacity
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Abstract Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because it is biocompatible and biodegradable. One disadvantage of traditional polymeric micelles is that they include a large amount of inert carrier materials, which do not contribute to therapeutic activity but increase cost and toxicity risk. A better alternative may be "dual-functional" micellar carriers, in which the hydrophobic carrier material (conjugated to PEG) has intrinsic therapeutic activity that complements, or even synergizes with, the antitumor activity of the drug cargo. This review summarizes recent progress in the development of PEG-derivatized dual-functional nanomicelles and surveys the evidence of their feasibility and promise for cancer therapy.
AbstractList Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because it is biocompatible and biodegradable. One disadvantage of traditional polymeric micelles is that they include a large amount of inert carrier materials, which do not contribute to therapeutic activity but increase cost and toxicity risk. A better alternative may be “dual-functional” micellar carriers, in which the hydrophobic carrier material (conjugated to PEG) has intrinsic therapeutic activity that complements, or even synergizes with, the antitumor activity of the drug cargo. This review summarizes recent progress in the development of PEG-derivatized dual-functional nanomicelles and surveys the evidence of their feasibility and promise for cancer therapy.
Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because it is biocompatible and biodegradable. One disadvantage of traditional polymeric micelles is that they include a large amount of inert carrier materials, which do not contribute to therapeutic activity but increase cost and toxicity risk. A better alternative may be "dual-functional" micellar carriers, in which the hydrophobic carrier material (conjugated to PEG) has intrinsic therapeutic activity that complements, or even synergizes with, the antitumor activity of the drug cargo. This review summarizes recent progress in the development of PEG-derivatized dual-functional nanomicelles and surveys the evidence of their feasibility and promise for cancer therapy.Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been approved for human use by the US Food and Drug Administration, is the most commonly used hydrophilic component of polymeric micelles because it is biocompatible and biodegradable. One disadvantage of traditional polymeric micelles is that they include a large amount of inert carrier materials, which do not contribute to therapeutic activity but increase cost and toxicity risk. A better alternative may be "dual-functional" micellar carriers, in which the hydrophobic carrier material (conjugated to PEG) has intrinsic therapeutic activity that complements, or even synergizes with, the antitumor activity of the drug cargo. This review summarizes recent progress in the development of PEG-derivatized dual-functional nanomicelles and surveys the evidence of their feasibility and promise for cancer therapy.
Author Liu, Qinhui
Zhang, Ting
He, Jinhan
Li, Yanping
AuthorAffiliation 2 Department of Pharmacy, West China Hospital of Sichuan University , Chengdu , China
1 Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital of Sichuan University , Chengdu , China
AuthorAffiliation_xml – name: 2 Department of Pharmacy, West China Hospital of Sichuan University , Chengdu , China
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  givenname: Qinhui
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31379579$$D View this record in MEDLINE/PubMed
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Keywords cancer immunochemotherapy
cancer therapy
multidrug resistance
dual-functional nanomicelles
polyethylene glycol (PEG)
drug loading capacity
Language English
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Reviewed by: Baolin Guo, Xi’an Jiaotong University, China; Song Li, University of Pittsburgh, United States
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Snippet Polymeric micelles have attracted considerable attention for effective delivery of poorly water-soluble cancer drugs. Polyethylene glycol (PEG), which has been...
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SubjectTerms cancer immunochemotherapy
cancer therapy
drug loading capacity
dual-functional nanomicelles
multidrug resistance
Pharmacology
polyethylene glycol (PEG)
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Title PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy
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