Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated Invariant T Cells in Chronic Hepatitis B Virus Infection

• Published in: Frontiers in immunology Vol. 9; p. 472
• Main Authors: Yong, Yean K., Saeidi, Alireza, Tan, Hong Y., Rosmawati, Mohamed, Enström, Philip F., Batran, Rami Al, Vasuki, V., Chattopadhyay, Indranil, Murugesan, Amudhan, Vignesh, Ramachandran, Kamarulzaman, Adeeba, Rajarajeswaran, Jayakumar, Ansari, Abdul W., Vadivelu, Jamuna, Ussher, James E., Velu, Vijayakumar, Larsson, Marie, Shankar, Esaki M.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.03.2018
• Subjects: HBV infection; HLA-DR; immune exhaustion; Immunology; immunosenescence; mucosal-associated invariant T cells; PD-1; immunosenescence; HLA-DR; HBV infection; mucosal-associated invariant T cells; CTLA-4; immune exhaustion; PD-1

Mucosal-associated invariant T (MAIT) cells, defined as CD161 TCR iVα7.2 T cells, play an important role in the innate defense against bacterial infections, and their functionality is impaired in chronic viral infections. Here, we investigated the frequency and functional role of MAIT cells in chron...