Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 33; no. 2; pp. 406 - 412
• Main Authors: Violi, Francesco, Pignatelli, Pasquale, Pignata, Claudio, Plebani, Alessandro, Rossi, Paolo, Sanguigni, Valerio, Carnevale, Roberto, Soresina, Annarosa, Finocchi, Andrea, Cirillo, Emilia, Catasca, Elisa, Angelico, Francesco, Loffredo, Lorenzo
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.02.2013
• Subjects: Adult; Atherosclerosis - enzymology; Atherosclerosis - genetics; Atherosclerosis - pathology; Atherosclerosis - physiopathology; Atherosclerosis - prevention & control; Biomarkers - blood; Biomarkers - urine; Brachial Artery - physiopathology; Carotid Intima-Media Thickness; Case-Control Studies; Chi-Square Distribution; Female; Genetic Predisposition to Disease; Humans; Isoprostanes - blood; Isoprostanes - urine; Italy; Linear Models; Membrane Glycoproteins - blood; Membrane Glycoproteins - genetics; Middle Aged; NADPH Oxidase 2; NADPH Oxidases - blood; NADPH Oxidases - genetics; Nitrates - blood; Nitrites - blood; Obesity - enzymology; Obesity - pathology; Obesity - physiopathology; Oxidative Stress - genetics; Phenotype; Predictive Value of Tests; Vasodilation

OBJECTIVE—NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced at...