Evaluation of the suitability of ex vivo handled ovarian tissues for optical diagnosis by Raman microspectroscopy

• Published in: Biopolymers Vol. 79; no. 5; pp. 269 - 276
• Main Authors: Krishna, C. Murali, Sockalingum, G. D., Venteo, L., Bhat, Rani A., Kushtagi, Pralhad, Pluot, M., Manfait, M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.12.2005
• Subjects: Biochemistry - methods; Biomarkers, Tumor; characterization; classification; Female; Fixatives - chemistry; Formaldehyde - chemistry; Formaldehyde - pharmacology; Humans; Immunohistochemistry; Micro-Raman spectroscopy; Ovarian Neoplasms - diagnosis; ovarian tissues; Ovary - pathology; Paraffin Embedding - methods; Principal Component Analysis; Specimen Handling; Spectrum Analysis, Raman - methods; Tissue Fixation - methods; tissue handling; Tissue Preservation

A pilot Raman microspectroscopy study of formalin‐fixed, paraffin‐embedded, and deparaffinized sections from the same ovarian normal and malignant tissues was carried out. This approach was considered in order to evaluate the suitability of these ex vivo tissue handling procedures in discrimination...