A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients
To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions of propofol using protocols that include scheduled daily interruption of sedation. A randomized open-label trial enrolling patients from October 20...
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Published in | Critical care medicine Vol. 34; no. 5; p. 1326 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
01.05.2006
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Abstract | To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions of propofol using protocols that include scheduled daily interruption of sedation.
A randomized open-label trial enrolling patients from October 2001 to March 2004.
Medical intensive care units of two tertiary care medical centers.
Adult patients expected to require mechanical ventilation for >48 hrs and who required > or =10 mg of lorazepam or a continuous infusion of a sedative to achieve adequate sedation.
Patients were randomized to receive lorazepam by intermittent bolus administration or propofol by continuous infusion to maintain a Ramsay score of 2-3. Sedation was interrupted on a daily basis for both groups.
The primary outcome was median ventilator days. Secondary outcomes included 28-day ventilator-free survival, intensive care unit and hospital length of stay, and hospital mortality. Median ventilator days were significantly lower in the daily interruption propofol group compared with the intermittent bolus lorazepam group (5.8 vs. 8.4, p = .04). The difference was largest for hospital survivors (4.4 vs. 9.0, p = .006). There was a trend toward greater ventilator-free survival for patients in the daily interruption propofol group (median 18.5 days for propofol vs. 10.2 for lorazepam, p = .06). Hospital mortality was not different.
For medical patients requiring >48 hrs of mechanical ventilation, sedation with propofol results in significantly fewer ventilator days compared with intermittent lorazepam when sedatives are interrupted daily. |
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AbstractList | To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions of propofol using protocols that include scheduled daily interruption of sedation.
A randomized open-label trial enrolling patients from October 2001 to March 2004.
Medical intensive care units of two tertiary care medical centers.
Adult patients expected to require mechanical ventilation for >48 hrs and who required > or =10 mg of lorazepam or a continuous infusion of a sedative to achieve adequate sedation.
Patients were randomized to receive lorazepam by intermittent bolus administration or propofol by continuous infusion to maintain a Ramsay score of 2-3. Sedation was interrupted on a daily basis for both groups.
The primary outcome was median ventilator days. Secondary outcomes included 28-day ventilator-free survival, intensive care unit and hospital length of stay, and hospital mortality. Median ventilator days were significantly lower in the daily interruption propofol group compared with the intermittent bolus lorazepam group (5.8 vs. 8.4, p = .04). The difference was largest for hospital survivors (4.4 vs. 9.0, p = .006). There was a trend toward greater ventilator-free survival for patients in the daily interruption propofol group (median 18.5 days for propofol vs. 10.2 for lorazepam, p = .06). Hospital mortality was not different.
For medical patients requiring >48 hrs of mechanical ventilation, sedation with propofol results in significantly fewer ventilator days compared with intermittent lorazepam when sedatives are interrupted daily. |
Author | Bourdet, Sharya Vinayak, Ajeet Kress, John P Hall, Jesse Rich, Preston B Ivanova, Anastasia Chang, Lydia Rodgers, Jo Ellen Pohlman, Anne Levitt, Joseph Henderson, Ashley G Carson, Shannon S Campbell-Bright, Stacy |
Author_xml | – sequence: 1 givenname: Shannon S surname: Carson fullname: Carson, Shannon S email: scarson@med.unc.edu organization: Division of Pulmonary and Critical Care, Department of Medicine, University of North Carolina at Chapel Hill, 4134 Bioinformatics Building, Chapel Hill, NC 27599-7020, USA. scarson@med.unc.edu – sequence: 2 givenname: John P surname: Kress fullname: Kress, John P – sequence: 3 givenname: Jo Ellen surname: Rodgers fullname: Rodgers, Jo Ellen – sequence: 4 givenname: Ajeet surname: Vinayak fullname: Vinayak, Ajeet – sequence: 5 givenname: Stacy surname: Campbell-Bright fullname: Campbell-Bright, Stacy – sequence: 6 givenname: Joseph surname: Levitt fullname: Levitt, Joseph – sequence: 7 givenname: Sharya surname: Bourdet fullname: Bourdet, Sharya – sequence: 8 givenname: Anastasia surname: Ivanova fullname: Ivanova, Anastasia – sequence: 9 givenname: Ashley G surname: Henderson fullname: Henderson, Ashley G – sequence: 10 givenname: Anne surname: Pohlman fullname: Pohlman, Anne – sequence: 11 givenname: Lydia surname: Chang fullname: Chang, Lydia – sequence: 12 givenname: Preston B surname: Rich fullname: Rich, Preston B – sequence: 13 givenname: Jesse surname: Hall fullname: Hall, Jesse |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16540958$$D View this record in MEDLINE/PubMed |
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Title | A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients |
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