Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study

The pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic or pathophysiological biomarkers. This pilot study's primary objective was to explore the pathophysiology of BMS through a comparative...

Full description

Saved in:
Bibliographic Details
Published inPain (Amsterdam) Vol. 164; no. 3; pp. e144 - e156
Main Authors Moreau, Charlotte, El Habnouni, Chakib, Lecron, Jean-Claude, Morel, Franck, Delwail, Adriana, Le Gall-Ianotto, Christelle, Le Garrec, Raphaele, Misery, Laurent, Piver, Eric, Vaillant, Loïc, Lefevre, Antoine, Emond, Patrick, Blasco, Hélène, Samimi, Mahtab
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer 01.03.2023
Lippincott, Williams & Wilkins
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic or pathophysiological biomarkers. This pilot study's primary objective was to explore the pathophysiology of BMS through a comparative analysis of the salivary metabolome among 26 BMS female cases and 25 age- and sex-matched control subjects. Secondary objectives included comparative analyses of inflammatory cytokines, neuroinflammatory markers, and steroid hormones among cases and control subjects, and among BMS patients according to their clinical characteristics. Salivary metabolome, neuroinflammatory markers, cytokines, and steroids were, respectively, analysed by liquid chromatography coupled with mass spectrometry, ELISA and protease activity assay, and multiparametric Luminex method. Among the 166 detected metabolites, univariate analysis did not find any discriminant metabolite between groups. Supervised multivariate analysis divided patients into 2 groups with an accuracy of 60% but did not allow significant discrimination (permutation test, P = 0.35). Among the metabolites contributing to the model, 3 belonging to the tyrosine pathway ( l -dopa, l -tyrosine, and tyramine) were involved in the discrimination between cases and control subjects, and among BMS patients according to their levels of pain. Among the detectable molecules, levels of cytokines, steroid hormones, and neuroinflammatory markers did not differ between cases and control subjects and were not associated with characteristics of BMS patients. These results do not support the involvement of steroid hormones, inflammatory cytokines, or inflammatory neurogenic mediators in the pathophysiology of pain in BMS, whereas the observed shift in tyrosine metabolism may indicate an adaptative response to chronic pain or an impaired dopaminergic transmission.
AbstractList The pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic or pathophysiological biomarkers. This pilot study's primary objective was to explore the pathophysiology of BMS through a comparative analysis of the salivary metabolome among 26 BMS female cases and 25 age- and sex-matched control subjects. Secondary objectives included comparative analyses of inflammatory cytokines, neuroinflammatory markers, and steroid hormones among cases and control subjects, and among BMS patients according to their clinical characteristics. Salivary metabolome, neuroinflammatory markers, cytokines, and steroids were, respectively, analysed by liquid chromatography coupled with mass spectrometry, ELISA and protease activity assay, and multiparametric Luminex method. Among the 166 detected metabolites, univariate analysis did not find any discriminant metabolite between groups. Supervised multivariate analysis divided patients into 2 groups with an accuracy of 60% but did not allow significant discrimination (permutation test, P = 0.35). Among the metabolites contributing to the model, 3 belonging to the tyrosine pathway ( l -dopa, l -tyrosine, and tyramine) were involved in the discrimination between cases and control subjects, and among BMS patients according to their levels of pain. Among the detectable molecules, levels of cytokines, steroid hormones, and neuroinflammatory markers did not differ between cases and control subjects and were not associated with characteristics of BMS patients. These results do not support the involvement of steroid hormones, inflammatory cytokines, or inflammatory neurogenic mediators in the pathophysiology of pain in BMS, whereas the observed shift in tyrosine metabolism may indicate an adaptative response to chronic pain or an impaired dopaminergic transmission.
ABSTRACTThe pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic or pathophysiological biomarkers. This pilot study's primary objective was to explore the pathophysiology of BMS through a comparative analysis of the salivary metabolome among 26 BMS female cases and 25 age- and sex-matched control subjects. Secondary objectives included comparative analyses of inflammatory cytokines, neuroinflammatory markers, and steroid hormones among cases and control subjects, and among BMS patients according to their clinical characteristics. Salivary metabolome, neuroinflammatory markers, cytokines, and steroids were, respectively, analysed by liquid chromatography coupled with mass spectrometry, ELISA and protease activity assay, and multiparametric Luminex method. Among the 166 detected metabolites, univariate analysis did not find any discriminant metabolite between groups. Supervised multivariate analysis divided patients into 2 groups with an accuracy of 60% but did not allow significant discrimination (permutation test, P = 0.35). Among the metabolites contributing to the model, 3 belonging to the tyrosine pathway ( l -dopa, l -tyrosine, and tyramine) were involved in the discrimination between cases and control subjects, and among BMS patients according to their levels of pain. Among the detectable molecules, levels of cytokines, steroid hormones, and neuroinflammatory markers did not differ between cases and control subjects and were not associated with characteristics of BMS patients. These results do not support the involvement of steroid hormones, inflammatory cytokines, or inflammatory neurogenic mediators in the pathophysiology of pain in BMS, whereas the observed shift in tyrosine metabolism may indicate an adaptative response to chronic pain or an impaired dopaminergic transmission.
Author Moreau, Charlotte
Blasco, Hélène
Samimi, Mahtab
Le Gall-Ianotto, Christelle
Lecron, Jean-Claude
Vaillant, Loïc
Morel, Franck
El Habnouni, Chakib
Delwail, Adriana
Misery, Laurent
Emond, Patrick
Lefevre, Antoine
Le Garrec, Raphaele
Piver, Eric
AuthorAffiliation Univ Brest, LIEN (Laboratoire Interactions Epithelium Neurones), Brest, France
Laboratory Inflammation, Tissus Epithéliaux et Cytokines, Poitiers University and Immunology/inflammation Laboratory, Poitiers University Hospital, Poitiers, France
ImageUP, Plate-forme d’Imagerie and Laboratoire Signalisation et Transport Ioniques Membranaires ERL CNRS 7003/EA 7349, Poitiers University, Poitiers, France
UMR 1253 iBrain, Université de Tours, Inserm, Tours, France
AuthorAffiliation_xml – name: Univ Brest, LIEN (Laboratoire Interactions Epithelium Neurones), Brest, France
– name: Laboratory Inflammation, Tissus Epithéliaux et Cytokines, Poitiers University and Immunology/inflammation Laboratory, Poitiers University Hospital, Poitiers, France
– name: ImageUP, Plate-forme d’Imagerie and Laboratoire Signalisation et Transport Ioniques Membranaires ERL CNRS 7003/EA 7349, Poitiers University, Poitiers, France
– name: UMR 1253 iBrain, Université de Tours, Inserm, Tours, France
Author_xml – sequence: 1
  givenname: Charlotte
  surname: Moreau
  fullname: Moreau, Charlotte
  organization: University François Rabelais, Tours, France
– sequence: 2
  givenname: Chakib
  surname: El Habnouni
  fullname: El Habnouni, Chakib
  organization: University François Rabelais, Tours, France
– sequence: 3
  givenname: Jean-Claude
  surname: Lecron
  fullname: Lecron, Jean-Claude
  organization: Laboratory Inflammation, Tissus Epithéliaux et Cytokines, Poitiers University and Immunology/inflammation Laboratory, Poitiers University Hospital, Poitiers, France
– sequence: 4
  givenname: Franck
  surname: Morel
  fullname: Morel, Franck
  organization: Laboratory Inflammation, Tissus Epithéliaux et Cytokines, Poitiers University and Immunology/inflammation Laboratory, Poitiers University Hospital, Poitiers, France
– sequence: 5
  givenname: Adriana
  surname: Delwail
  fullname: Delwail, Adriana
  organization: ImageUP, Plate-forme d’Imagerie and Laboratoire Signalisation et Transport Ioniques Membranaires ERL CNRS 7003/EA 7349, Poitiers University, Poitiers, France
– sequence: 6
  givenname: Christelle
  surname: Le Gall-Ianotto
  fullname: Le Gall-Ianotto, Christelle
  organization: Univ Brest, LIEN (Laboratoire Interactions Epithelium Neurones), Brest, France
– sequence: 7
  givenname: Raphaele
  surname: Le Garrec
  fullname: Le Garrec, Raphaele
  organization: Univ Brest, LIEN (Laboratoire Interactions Epithelium Neurones), Brest, France
– sequence: 8
  givenname: Laurent
  surname: Misery
  fullname: Misery, Laurent
  organization: Univ Brest, LIEN (Laboratoire Interactions Epithelium Neurones), Brest, France
– sequence: 9
  givenname: Eric
  surname: Piver
  fullname: Piver, Eric
  organization: Department of Biochemistry and Molecular Biology, University Hospital of Tours, Tours Cedex, France
– sequence: 10
  givenname: Loïc
  surname: Vaillant
  fullname: Vaillant, Loïc
  organization: University François Rabelais, Tours, France
– sequence: 11
  givenname: Antoine
  surname: Lefevre
  fullname: Lefevre, Antoine
  organization: UMR 1253 iBrain, Université de Tours, Inserm, Tours, France
– sequence: 12
  givenname: Patrick
  surname: Emond
  fullname: Emond, Patrick
  organization: UMR 1253 iBrain, Université de Tours, Inserm, Tours, France
– sequence: 13
  givenname: Hélène
  surname: Blasco
  fullname: Blasco, Hélène
  organization: Department of Biochemistry and Molecular Biology, University Hospital of Tours, Tours Cedex, France
– sequence: 14
  givenname: Mahtab
  surname: Samimi
  fullname: Samimi, Mahtab
  organization: University François Rabelais, Tours, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35916738$$D View this record in MEDLINE/PubMed
https://hal.inrae.fr/hal-03886871$$DView record in HAL
BookMark eNpdkc1u1DAUhS1URKeFVwAvYZHBP4kds6sqSpFGYgGsLce5IR4cZ4idGc2OJfu-IU-Cw7QVwhvLR98511fnAp2FMQBCryhZU6Lk2-16Z1xYk38Ok5w_QStaS1YIwfgZWhFOyoKrSp2jixi3C8SYeobOeaWokLxeoV-fjXd7Mx3xAMk0ox8HwC60zpoEERsce9elrOB0nMboAjyALg6LvDPJQUgRH1zqcTNPwYVveBjn_IrH0E458F3O2WX3Dmxye8DWRPj9886OIU2jxzHN7fE5etoZH-HF_X2Jvt68_3J9W2w-ffh4fbUpLFeMF2BaI-qKW-AdKC67umo7SilpmW1JVYJVtm4aRamomGINKZtaqqYGZhqwJeWX6M0ptzde7yY35N31aJy-vdroRSO8rkUt6X5hX5_Y_PkfM8SkBxcteG8CjHPUTCjJhSglyag8oTbvGSfoHrMp0UtlequXyvT_lWXny_shczNA--h76CgD5Qk4jD7BFL_7-QCT7sH41P_NE1yJghHGc-GEFEsy538AkjaoaA
CitedBy_id crossref_primary_10_1038_s41392_023_01399_3
crossref_primary_10_1016_j_oooo_2023_10_002
crossref_primary_10_3390_ani13122024
crossref_primary_10_3389_fvets_2024_1396492
crossref_primary_10_1111_joor_13407
Cites_doi 10.1111/j.1460-9568.2007.05623.x
10.1002/brb3.214
10.3389/fimmu.2020.588322
10.1038/srep06802
10.21873/invivo.11587
10.1038/srep31520
10.1002/ijc.25881
10.1155/MI/2006/54632
10.1016/0304-3959(87)90113-8
10.3390/molecules26144111
10.1016/j.jocn.2006.09.002
10.1016/j.jns.2012.07.007
10.1007/s10072-015-2131-3
10.1016/S0034-7094(11)70029-0
10.1212/01.WNL.0000125188.79106.29
10.1016/S0304-3959(02)00323-8
10.3390/dj8040111
10.3390/metabo10020047
10.1371/journal.pone.0080766
10.1177/0333102417738202
10.1111/j.1365-2567.2007.02705.x
10.1016/j.cca.2018.11.030
10.1111/odi.12802
10.1016/j.cyto.2021.155506
10.1371/journal.pone.0105181
10.1111/ipd.12270
10.1016/j.pain.2005.03.028
10.1177/0300060517745388
10.1016/j.jpain.2006.02.011
10.1016/j.intimp.2008.03.002
10.1146/annurev.psych.51.1.29
10.1128/CMR.00021-13
10.1111/cei.12683
10.1097/MOO.0000000000000502
10.1111/j.1601-0825.2005.01209.x
10.1177/1744806916686796
10.1373/clinchem.2010.153767
10.1111/joor.12795
10.1002/bmc.3886
10.1371/journal.pone.0204249
10.1097/00001756-199304000-00002
10.1177/154411130301400405
10.1371/journal.pntd.0002198
10.1523/JNEUROSCI.20-16-06289.2000
10.3390/biom11081237
10.1016/j.archoralbio.2009.05.007
10.1016/j.nrl.2015.10.008
10.3892/or.2017.5561
10.1371/journal.pone.0107626
10.1038/s41598-019-41297-9
10.1016/j.tripleo.2007.10.002
10.1016/S0304-3959(03)00275-6
10.4097/kjae.2017.70.6.601
10.1021/ac9020598
10.12998/wjcc.v9.i23.6916
10.1111/odi.12630
10.1007/s11306-019-1593-3
10.11607/ofph.1691
10.3390/jcm9040929
10.3390/metabo11070429
10.4103/0976-237X.183059
10.1111/j.1533-2500.2007.00124.x
10.1016/j.clim.2007.08.014
10.1097/j.pain.0000000000002052
10.1007/s11306-009-0178-y
10.1002/ejp.1871
10.11607/jop.1038
10.1002/jor.22949
10.1016/j.cca.2017.05.037
10.1111/j.1741-2358.1998.00073.x
10.1177/0333102413480755
10.1177/0022034516661142
10.1016/0003-9969(88)90117-3
10.1016/S0304-3959(03)00067-8
10.1016/j.pain.2013.10.005
10.1111/j.1601-0825.2009.01648.x
10.1007/s10194-008-0003-4
10.1016/j.joca.2015.12.004
10.1111/j.1601-0825.2012.01937.x
10.1016/S0304-3959(03)00261-6
10.1007/s00280-015-2750-7
10.1111/scd.12214
10.1016/j.bbagen.2018.07.003
10.1007/s11306-019-1513-6
10.1177/17448069211041853
10.1159/000367714
10.1017/S002966511900106X
10.1016/j.clinbiochem.2012.09.009
10.1016/j.archoralbio.2004.01.012
10.1016/S0304-3959(00)00409-7
10.1016/0304-3959(93)90204-3
ContentType Journal Article
Copyright Wolters Kluwer
Copyright © 2022 International Association for the Study of Pain.
Copyright
Copyright_xml – notice: Wolters Kluwer
– notice: Copyright © 2022 International Association for the Study of Pain.
– notice: Copyright
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
1XC
DOI 10.1097/j.pain.0000000000002733
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Hyper Article en Ligne (HAL)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic

Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1872-6623
EndPage e156
ExternalDocumentID oai_HAL_hal_03886871v1
10_1097_j_pain_0000000000002733
35916738
00006396-202303000-00023
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
--K
026
0R~
123
1B1
1~5
4.4
71M
AAAAV
AAAXR
AACTN
AAGIX
AAHPQ
AAIQE
AAMOA
AAQKA
AARTV
AASCR
AASXQ
AAUEB
AAXQO
ABASU
ABBUW
ABDIG
ABIVO
ABJNI
ABLJU
ABOCM
ABVCZ
ABXVJ
ABZAD
ACDDN
ACEWG
ACGFO
ACGFS
ACILI
ACLDA
ACNWC
ACOAL
ACWDW
ACWRI
ACXJB
ACXNZ
ADGGA
ADHPY
AEKER
AENEX
AFDTB
AFSOK
AGGSO
AHOMT
AHQNM
AHVBC
AHXIK
AIJEX
AINUH
AJIOK
AJNWD
AJZMW
AKRWK
AKULP
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
AMNEI
AOHHW
BOYCO
BQLVK
BYPQX
C45
CS3
DIWNM
DU5
EBS
EEVPB
ERAAH
EX3
F5P
FCALG
FDB
GNXGY
GQDEL
HLJTE
HMQ
HZ~
IHE
IKREB
IKYAY
L-C
L7B
MJL
MO0
N9A
O-L
O9-
OBH
OJAPA
OLW
OPUJH
OVD
OVDNE
OVIDH
OVLEI
OVOZU
OXXIT
OZT
P2P
RLZ
RPZ
SCC
SEL
SES
TEORI
TSPGW
TWZ
CGR
CUY
CVF
ECM
EIF
NPM
.55
.GJ
.~1
1CY
1RT
1~.
29O
3O-
4G.
53G
5VS
7-5
9JO
AABNK
AAGUQ
AAIKJ
AALRI
AAQFI
AAQQT
AAXUO
AAYXX
ABBQC
ABCQJ
ABFNM
ABMAC
ABZDS
ACIUM
ACJTP
ACXNI
ADBBV
ADNKB
AEETU
AERZD
AFXBA
AGWIK
AGYEJ
AHHHB
AITUG
AJNYG
AJRQY
ALCLG
AMRAJ
CITATION
DUNZO
EJD
EO8
EO9
EP2
EP3
FEDTE
FGOYB
FIRID
FNPLU
G-2
G-Q
HDV
HMK
HMO
HVGLF
H~9
IPNFZ
J1W
J5H
LX1
M29
M2V
M41
OHT
OUVQU
P-8
P-9
PC.
Q38
R2-
RIG
ROL
SAE
SDF
SDG
SDP
SEW
SNS
SSZ
WUQ
X7M
XPP
YCJ
ZGI
ZZMQN
7X8
1XC
ID FETCH-LOGICAL-c3923-eada6853ce3fe937f85df1110d2cd054ec9c8bb91165292b04b879b8e2abec413
ISSN 0304-3959
IngestDate Tue Oct 15 16:01:53 EDT 2024
Fri Oct 25 09:52:57 EDT 2024
Fri Nov 22 00:29:43 EST 2024
Wed Oct 16 00:40:34 EDT 2024
Thu Nov 14 18:59:24 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
License Copyright © 2022 International Association for the Study of Pain.
Copyright: http://hal.archives-ouvertes.fr/licences/copyright
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c3923-eada6853ce3fe937f85df1110d2cd054ec9c8bb91165292b04b879b8e2abec413
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-9665-5815
0000-0001-6107-0035
0000-0002-5324-2164
0000-0003-3812-9304
0000-0003-3990-5213
0000-0001-6742-9088
PMID 35916738
PQID 2697366470
PQPubID 23479
ParticipantIDs hal_primary_oai_HAL_hal_03886871v1
proquest_miscellaneous_2697366470
crossref_primary_10_1097_j_pain_0000000000002733
pubmed_primary_35916738
wolterskluwer_health_00006396-202303000-00023
PublicationCentury 2000
PublicationDate 2023-March-01
2023-03-01
2023-03-00
20230301
2023-03
PublicationDateYYYYMMDD 2023-03-01
PublicationDate_xml – month: 03
  year: 2023
  text: 2023-March-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Pain (Amsterdam)
PublicationTitleAlternate Pain
PublicationYear 2023
Publisher Wolters Kluwer
Lippincott, Williams & Wilkins
Publisher_xml – name: Wolters Kluwer
– name: Lippincott, Williams & Wilkins
References Ji (R42-20230213) 2017; 13
Nosratzehi (R70-20230213) 2017; 37
Wood (R94-20230213) 2007; 25
Castillo-Felipe (R17-20230213) 2021; 10
Krief (R46-20230213) 2019; 9
Aro (R5-20230213) 2019; 27
Guimarães (R31-20230213) 2006; 7
Woda (R92-20230213) 2009; 23
In (R38-20230213) 2017; 70
Martias (R62-20230213) 2021; 26
Barnes (R6-20230213) 2014; 9
Wang (R89-20230213) 2014; 4
Liu (R54-20230213) 2017; 31
Suh (R87-20230213) 2009; 54
Zuo (R100-20230213) 2003; 105
Lopez-Jornet (R58-20230213) 2020; 9
de Souza (R83-20230213) 2015; 22
Dufour-Rainfray (R25-20230213) 2015; 73
Grushka (R30-20230213) 1987; 28
Singh (R82-20230213) 2019; 15
(R34-20230213) 2018; 38
Lewis (R51-20230213) 2006; 27
Boras (R10-20230213) 2006; 12
Hagelberg (R33-20230213) 2003; 101
Lauria (R50-20230213) 2005; 115
Mikkonen (R68-20230213) 2012; 3
Wei (R91-20230213) 2011; 129
Ishikawa (R39-20230213) 2016; 6
Orliaguet (R74-20230213) 2021; 11
Imamura (R37-20230213) 2019; 46
Brennan (R14-20230213) 2020; 79
D'Andrea (R20-20230213) 2013; 33
Watkins (R90-20230213) 2000; 51
Hagelberg (R32-20230213) 2003; 106
Loeb (R55-20230213) 2008; 8
Cárcamo Fonfría (R16-20230213) 2017; 32
Scala (R79-20230213) 2003; 14
Bertram (R8-20230213) 2009; 81
Kulka (R48-20230213) 2008; 123
Menon (R66-20230213) 2016; 7
Yoshizawa (R97-20230213) 2013; 26
BrAud (R12-20230213) 2017; 23
Braud (R13-20230213) 2013; 27
Hershkovich (R35-20230213) 2004; 49
Kawanishi (R44-20230213) 2019; 489
Zhang (R99-20230213) 2016; 24
Gewehr (R29-20230213) 2013; 7
Clifford (R18-20230213) 1998; 15
JaÈaÈskelaÈinen (R40-20230213) 2001; 90
Diesch (R23-20230213) 2021; 143
Labus (R49-20230213) 2021; 17
Prakash (R77-20230213) 2012; 320
Jenzano (R41-20230213) 1988; 33
Pfaffe (R76-20230213) 2011; 57
Sharma (R80-20230213) 2017; 471
Kim (R45-20230213) 2012; 18
Ohshima (R71-20230213) 2017; 37
Alexander (R2-20230213) 2013; 2013
Gawron (R28-20230213) 2019; 33
Mearow (R64-20230213) 1993; 4
Masson Regnault (R63-20230213) 2020; 11
Santos (R78-20230213) 2017; 27
Xia (R95-20230213) 2003; 21
Simcić (R81-20230213) 2006; 2006
Oprée (R73-20230213) 2000; 20
Yilmaz (R96-20230213) 2007; 14
D'Andrea (R21-20230213) 2004; 62
Aghabeigi (R1-20230213) 1993; 54
de Oliveira (R72-20230213) 2011; 61
Liu (R53-20230213) 2021; 162
Kuboniwa (R47-20230213) 2016; 95
Lončar-Brzak (R57-20230213) 2020; 8
Lohavanichbutr (R56-20230213) 2018; 13
D'Andrea (R19-20230213) 2015; 36
Maltsman-Tseikhin (R60-20230213) 2007; 7
Meissner (R65-20230213) 2014; 155
Mickiewicz (R67-20230213) 2015; 33
Srinivasan (R84-20230213) 2008; 126
Trbojević-Akmačić (R88-20230213) 2018; 1862
Wolf (R93-20230213) 2003; 104
Nadal (R69-20230213) 2018; 24
Li (R52-20230213) 2018; 46
Pels (R75-20230213) 2015; 76
Buchanan (R98-20230213) 2008; 2008
Hsu (R36-20230213) 2022; 26
Sugimoto (R86-20230213) 2010; 6
Becker (R7-20230213) 2013; 8
Malatji (R59-20230213) 2019; 15
Stuginski-Barbosa (R85-20230213) 2008; 9
Marino (R61-20230213) 2021; 11
Du (R24-20230213) 2021; 9
Amenábar (R3-20230213) 2008; 105
Kageyama (R43-20230213) 2015; 182
Bonenfant (R9-20230213) 2016; 30
Caboni (R15-20230213) 2014; 9
Borelli (R11-20230213) 2010; 16
Gardner (R27-20230213) 2020; 10
Dieb (R22-20230213) 2014; 4
Fais (R26-20230213) 2013; 46
References_xml – volume: 25
  start-page: 3576
  year: 2007
  ident: R94-20230213
  article-title: Fibromyalgia patients show an abnormal dopamine response to pain
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2007.05623.x
  contributor:
    fullname: Wood
– volume: 4
  start-page: 368
  year: 2014
  ident: R22-20230213
  article-title: Lesion of the dopaminergic nigrostriatal pathway induces trigeminal dynamic mechanical allodynia
  publication-title: Brain Behav
  doi: 10.1002/brb3.214
  contributor:
    fullname: Dieb
– volume: 11
  start-page: 588322
  year: 2020
  ident: R63-20230213
  article-title: Cytokine signature in schnitzler syndrome: proinflammatory cytokine production associated to Th suppression
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.588322
  contributor:
    fullname: Masson Regnault
– volume: 4
  start-page: 6802
  year: 2014
  ident: R89-20230213
  article-title: The early diagnosis and monitoring of squamous cell carcinoma via saliva metabolomics
  publication-title: Sci Rep
  doi: 10.1038/srep06802
  contributor:
    fullname: Wang
– volume: 33
  start-page: 1165
  year: 2019
  ident: R28-20230213
  article-title: Metabolomic status of the oral cavity in chronic periodontitis
  publication-title: In Vivo
  doi: 10.21873/invivo.11587
  contributor:
    fullname: Gawron
– volume: 6
  start-page: 31520
  year: 2016
  ident: R39-20230213
  article-title: Identification of salivary metabolomic biomarkers for oral cancer screening
  publication-title: Sci Rep
  doi: 10.1038/srep31520
  contributor:
    fullname: Ishikawa
– volume: 129
  start-page: 2207
  year: 2011
  ident: R91-20230213
  article-title: Salivary metabolite signatures of oral cancer and leukoplakia
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25881
  contributor:
    fullname: Wei
– volume: 2006
  start-page: 54632
  year: 2006
  ident: R81-20230213
  article-title: Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome
  publication-title: Mediators Inflamm
  doi: 10.1155/MI/2006/54632
  contributor:
    fullname: Simcić
– volume: 28
  start-page: 155
  year: 1987
  ident: R30-20230213
  article-title: Pain and personality profiles in burning mouth syndrome
  publication-title: PAIN
  doi: 10.1016/0304-3959(87)90113-8
  contributor:
    fullname: Grushka
– volume: 26
  start-page: 4111
  year: 2021
  ident: R62-20230213
  article-title: Optimization of sample preparation for metabolomics exploration of urine, feces, blood and saliva in humans using combined NMR and UHPLC-HRMS platforms
  publication-title: Molecules
  doi: 10.3390/molecules26144111
  contributor:
    fullname: Martias
– volume: 14
  start-page: 864
  year: 2007
  ident: R96-20230213
  article-title: Burning mouth syndrome as a trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score
  publication-title: J Clin Neurosci
  doi: 10.1016/j.jocn.2006.09.002
  contributor:
    fullname: Yilmaz
– volume: 320
  start-page: 156
  year: 2012
  ident: R77-20230213
  article-title: Dopa responsive burning mouth syndrome: restless mouth syndrome or oral variant of restless legs syndrome?
  publication-title: J Neurol Sci
  doi: 10.1016/j.jns.2012.07.007
  contributor:
    fullname: Prakash
– volume: 36
  start-page: 17
  issue: suppl 1
  year: 2015
  ident: R19-20230213
  article-title: Biochemistry of primary headaches: role of tyrosine and tryptophan metabolism
  publication-title: Neurol Sci
  doi: 10.1007/s10072-015-2131-3
  contributor:
    fullname: D'Andrea
– volume: 61
  start-page: 255
  year: 2011
  ident: R72-20230213
  article-title: Cytokines and pain
  publication-title: Rev Bras Anestesiol
  doi: 10.1016/S0034-7094(11)70029-0
  contributor:
    fullname: de Oliveira
– volume: 62
  start-page: 1701
  year: 2004
  ident: R21-20230213
  article-title: Elevated levels of circulating trace amines in primary headaches
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000125188.79106.29
  contributor:
    fullname: D'Andrea
– volume: 101
  start-page: 149
  year: 2003
  ident: R33-20230213
  article-title: Striatal dopamine D1 and D2 receptors in burning mouth syndrome
  publication-title: PAIN
  doi: 10.1016/S0304-3959(02)00323-8
  contributor:
    fullname: Hagelberg
– volume: 8
  start-page: E111
  year: 2020
  ident: R57-20230213
  article-title: Salivary hormones and quality of life in female postmenopausal burning mouth patients-A pilot case-control study
  publication-title: Dent J (Basel)
  doi: 10.3390/dj8040111
  contributor:
    fullname: Lončar-Brzak
– volume: 10
  start-page: E47
  year: 2020
  ident: R27-20230213
  article-title: Salivary metabolomics: from diagnostic biomarker discovery to investigating biological function
  publication-title: Metabolites
  doi: 10.3390/metabo10020047
  contributor:
    fullname: Gardner
– volume: 8
  start-page: e80766
  year: 2013
  ident: R7-20230213
  article-title: Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0080766
  contributor:
    fullname: Becker
– volume: 38
  start-page: 1
  year: 2018
  ident: R34-20230213
  article-title: Headache Classification Committee of the International Headache Society (IHS) The international classification of headache disorders, 3rd edition
  publication-title: Cephalalgia
  doi: 10.1177/0333102417738202
– volume: 123
  start-page: 398
  year: 2008
  ident: R48-20230213
  article-title: Neuropeptides activate human mast cell degranulation and chemokine production
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2007.02705.x
  contributor:
    fullname: Kulka
– volume: 489
  start-page: 41
  year: 2019
  ident: R44-20230213
  article-title: Effects of inter-day and intra-day variation on salivary metabolomic profiles
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2018.11.030
  contributor:
    fullname: Kawanishi
– volume: 23
  start-page: 202
  year: 2009
  ident: R92-20230213
  article-title: Steroid dysregulation and stomatodynia (burning mouth syndrome)
  publication-title: J Orofac Pain
  contributor:
    fullname: Woda
– volume: 24
  start-page: 552
  year: 2018
  ident: R69-20230213
  article-title: Salivary scintigraphy for Sjögren’s syndrome in patients with xerostomia: a retrospective study
  publication-title: Oral Dis
  doi: 10.1111/odi.12802
  contributor:
    fullname: Nadal
– volume: 143
  start-page: 155506
  year: 2021
  ident: R23-20230213
  article-title: Cytokines in saliva as biomarkers of oral and systemic oncological or infectious diseases: a systematic review
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2021.155506
  contributor:
    fullname: Diesch
– volume: 9
  start-page: e105181
  year: 2014
  ident: R6-20230213
  article-title: Global metabolomic analysis of human saliva and plasma from healthy and diabetic subjects, with and without periodontal disease
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0105181
  contributor:
    fullname: Barnes
– volume: 27
  start-page: 364
  year: 2017
  ident: R78-20230213
  article-title: Inflammatory markers in saliva as indicators of gingival inflammation in cerebral palsy children with and without cervical motor control
  publication-title: Int J Paediatr Dent
  doi: 10.1111/ipd.12270
  contributor:
    fullname: Santos
– volume: 115
  start-page: 332
  year: 2005
  ident: R50-20230213
  article-title: Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome
  publication-title: PAIN
  doi: 10.1016/j.pain.2005.03.028
  contributor:
    fullname: Lauria
– volume: 46
  start-page: 1052
  year: 2018
  ident: R52-20230213
  article-title: Salivary metabolomics profile of patients with recurrent aphthous ulcer as revealed by liquid chromatography-tandem mass spectrometry
  publication-title: J Int Med Res
  doi: 10.1177/0300060517745388
  contributor:
    fullname: Li
– volume: 7
  start-page: 654
  year: 2006
  ident: R31-20230213
  article-title: Interleukin-1beta and serotonin transporter gene polymorphisms in burning mouth syndrome patients
  publication-title: J Pain
  doi: 10.1016/j.jpain.2006.02.011
  contributor:
    fullname: Guimarães
– volume: 8
  start-page: 1056
  year: 2008
  ident: R55-20230213
  article-title: Chondroitin sulfate and kallikrein in saliva: markers for glossodynia
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2008.03.002
  contributor:
    fullname: Loeb
– volume: 51
  start-page: 29
  year: 2000
  ident: R90-20230213
  article-title: The pain of being sick: implications of immune-to-brain communication for understanding pain
  publication-title: Annu Rev Psychol
  doi: 10.1146/annurev.psych.51.1.29
  contributor:
    fullname: Watkins
– volume: 26
  start-page: 781
  year: 2013
  ident: R97-20230213
  article-title: Salivary biomarkers: toward future clinical and diagnostic utilities
  publication-title: Clin Microbiol Rev
  doi: 10.1128/CMR.00021-13
  contributor:
    fullname: Yoshizawa
– volume: 182
  start-page: 149
  year: 2015
  ident: R43-20230213
  article-title: Metabolomics analysis of saliva from patients with primary Sjögren’s syndrome
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12683
  contributor:
    fullname: Kageyama
– volume: 27
  start-page: 91
  year: 2019
  ident: R5-20230213
  article-title: Salivaomics in oral cancer
  publication-title: Curr Opin Otolaryngol Head Neck Surg
  doi: 10.1097/MOO.0000000000000502
  contributor:
    fullname: Aro
– volume: 12
  start-page: 353
  year: 2006
  ident: R10-20230213
  article-title: Salivary interleukin-6 and tumor necrosis factor-alpha in patients with burning mouth syndrome
  publication-title: Oral Dis
  doi: 10.1111/j.1601-0825.2005.01209.x
  contributor:
    fullname: Boras
– volume: 27
  start-page: 139
  year: 2006
  ident: R51-20230213
  article-title: Steroid analysis in saliva: an overview
  publication-title: Clin Biochem Rev
  contributor:
    fullname: Lewis
– volume: 13
  start-page: 1744806916686796
  year: 2017
  ident: R42-20230213
  article-title: Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics
  publication-title: Mol Pain
  doi: 10.1177/1744806916686796
  contributor:
    fullname: Ji
– volume: 57
  start-page: 675
  year: 2011
  ident: R76-20230213
  article-title: Diagnostic potential of saliva: current state and future applications
  publication-title: Clin Chem
  doi: 10.1373/clinchem.2010.153767
  contributor:
    fullname: Pfaffe
– volume: 46
  start-page: 574
  year: 2019
  ident: R37-20230213
  article-title: An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives
  publication-title: J Oral Rehabil
  doi: 10.1111/joor.12795
  contributor:
    fullname: Imamura
– volume: 31
  start-page: e3886
  year: 2017
  ident: R54-20230213
  article-title: Urinary metabolomics of complete Freund's adjuvant-induced hyperalgesia in rats: urinary metabolomics of Freund's adjuvant-induced hyperalgesia
  publication-title: Biomed Chromatogr
  doi: 10.1002/bmc.3886
  contributor:
    fullname: Liu
– volume: 73
  start-page: 70
  year: 2015
  ident: R25-20230213
  article-title: Mass spectrometry for steroid assays
  publication-title: Ann Biol Clin
  contributor:
    fullname: Dufour-Rainfray
– volume: 13
  start-page: e0204249
  year: 2018
  ident: R56-20230213
  article-title: Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0204249
  contributor:
    fullname: Lohavanichbutr
– volume: 4
  start-page: 351
  year: 1993
  ident: R64-20230213
  article-title: Increased NGF mRNA expression in denervated rat skin
  publication-title: Neuroreport
  doi: 10.1097/00001756-199304000-00002
  contributor:
    fullname: Mearow
– volume: 21
  start-page: 377
  year: 2003
  ident: R95-20230213
  article-title: Correlations among mood disorder, serum interleukin-2 and interleukin-6 in patients with burning mouth syndrome [in Chinese]
  publication-title: Hua Xi Kou Qiang Yi Xue Za Zhi
  contributor:
    fullname: Xia
– volume: 14
  start-page: 275
  year: 2003
  ident: R79-20230213
  article-title: Update on burning mouth syndrome: overview and patient management
  publication-title: Crit Rev Oral Biol Med
  doi: 10.1177/154411130301400405
  contributor:
    fullname: Scala
– volume: 7
  start-page: e2198
  year: 2013
  ident: R29-20230213
  article-title: Mechanisms involved in the nociception triggered by the venom of the armed spider phoneutria nigriventer
  publication-title: Plos Negl Trop Dis
  doi: 10.1371/journal.pntd.0002198
  contributor:
    fullname: Gewehr
– volume: 20
  start-page: 6289
  year: 2000
  ident: R73-20230213
  article-title: Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.20-16-06289.2000
  contributor:
    fullname: Oprée
– volume: 11
  start-page: 1237
  year: 2021
  ident: R74-20230213
  article-title: Neuropathic and psychogenic components of burning mouth syndrome: a systematic review
  publication-title: Biomolecules
  doi: 10.3390/biom11081237
  contributor:
    fullname: Orliaguet
– volume: 54
  start-page: 797
  year: 2009
  ident: R87-20230213
  article-title: Salivary levels of IL-1beta, IL-6, IL-8, and TNF-alpha in patients with burning mouth syndrome
  publication-title: Arch Oral Biol
  doi: 10.1016/j.archoralbio.2009.05.007
  contributor:
    fullname: Suh
– volume: 32
  start-page: 219
  year: 2017
  ident: R16-20230213
  article-title: Burning mouth syndrome: clinical description, pathophysiological approach, and a new therapeutic option
  publication-title: Neurología
  doi: 10.1016/j.nrl.2015.10.008
  contributor:
    fullname: Cárcamo Fonfría
– volume: 37
  start-page: 2727
  year: 2017
  ident: R71-20230213
  article-title: Metabolomic analysis of the saliva of Japanese patients with oral squamous cell carcinoma
  publication-title: Oncol Rep
  doi: 10.3892/or.2017.5561
  contributor:
    fullname: Ohshima
– volume: 9
  start-page: e107626
  year: 2014
  ident: R15-20230213
  article-title: Metabolomics analysis and modeling suggest a lysophosphocholines-PAF receptor interaction in fibromyalgia
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0107626
  contributor:
    fullname: Caboni
– volume: 9
  start-page: 4794
  year: 2019
  ident: R46-20230213
  article-title: Proteomic profiling of whole-saliva reveals correlation between Burning Mouth Syndrome and the neurotrophin signaling pathway
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-41297-9
  contributor:
    fullname: Krief
– volume: 105
  start-page: 460
  year: 2008
  ident: R3-20230213
  article-title: Anxiety and salivary cortisol levels in patients with burning mouth syndrome: case-control study
  publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  doi: 10.1016/j.tripleo.2007.10.002
  contributor:
    fullname: Amenábar
– volume: 106
  start-page: 43
  year: 2003
  ident: R32-20230213
  article-title: Altered dopamine D2 receptor binding in atypical facial pain
  publication-title: PAIN
  doi: 10.1016/S0304-3959(03)00275-6
  contributor:
    fullname: Hagelberg
– volume: 70
  start-page: 601
  year: 2017
  ident: R38-20230213
  article-title: Introduction of a pilot study
  publication-title: Korean J Anesthesiol
  doi: 10.4097/kjae.2017.70.6.601
  contributor:
    fullname: In
– volume: 81
  start-page: 9188
  year: 2009
  ident: R8-20230213
  article-title: Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification
  publication-title: Anal Chem
  doi: 10.1021/ac9020598
  contributor:
    fullname: Bertram
– volume: 3
  year: 2012
  ident: R68-20230213
  article-title: Metabolic profiling of saliva in patients with primary Sjogren's syndrome
  publication-title: Metabolomics
  contributor:
    fullname: Mikkonen
– volume: 9
  start-page: 6916
  year: 2021
  ident: R24-20230213
  article-title: Dopamine agonist responsive burning mouth syndrome: report of eight cases
  publication-title: World J Clin Cases
  doi: 10.12998/wjcc.v9.i23.6916
  contributor:
    fullname: Du
– volume: 23
  start-page: 395
  year: 2017
  ident: R12-20230213
  article-title: Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study
  publication-title: Oral Dis
  doi: 10.1111/odi.12630
  contributor:
    fullname: BrAud
– volume: 15
  start-page: 141
  year: 2019
  ident: R82-20230213
  article-title: Post-periodontal surgery propounds early repair salivary biomarkers by 1H NMR based metabolomics
  publication-title: Metabolomics
  doi: 10.1007/s11306-019-1593-3
  contributor:
    fullname: Singh
– volume: 2013
  start-page: 742407
  year: 2013
  ident: R2-20230213
  article-title: Plasma amino acids changes in complex regional pain syndrome
  publication-title: Pain Res Treat
  contributor:
    fullname: Alexander
– volume: 30
  start-page: 318
  year: 2016
  ident: R9-20230213
  article-title: Characterization of burning mouth syndrome in patients with Parkinson's disease
  publication-title: J Oral Facial Pain Headache
  doi: 10.11607/ofph.1691
  contributor:
    fullname: Bonenfant
– volume: 9
  start-page: E929
  year: 2020
  ident: R58-20230213
  article-title: Salivary biomarkers and their correlation with pain and stress in patients with burning mouth syndrome
  publication-title: J Clin Med
  doi: 10.3390/jcm9040929
  contributor:
    fullname: Lopez-Jornet
– volume: 11
  start-page: 429
  year: 2021
  ident: R61-20230213
  article-title: Fibromyalgia and depression in women: an 1H-NMR metabolomic study
  publication-title: Metabolites
  doi: 10.3390/metabo11070429
  contributor:
    fullname: Marino
– volume: 7
  start-page: 198
  year: 2016
  ident: R66-20230213
  article-title: Evaluation of salivary interleukin-6 in children with early childhood caries after treatment
  publication-title: Contemp Clin Dent
  doi: 10.4103/0976-237X.183059
  contributor:
    fullname: Menon
– volume: 7
  start-page: 151
  year: 2007
  ident: R60-20230213
  article-title: Burning mouth syndrome: will better understanding yield better management?
  publication-title: Pain Pract
  doi: 10.1111/j.1533-2500.2007.00124.x
  contributor:
    fullname: Maltsman-Tseikhin
– volume: 126
  start-page: 31
  year: 2008
  ident: R84-20230213
  article-title: Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2007.08.014
  contributor:
    fullname: Srinivasan
– volume: 162
  start-page: 600
  year: 2021
  ident: R53-20230213
  article-title: Metabolomic analysis coupled with extreme phenotype sampling identified that lysophosphatidylcholines are associated with multisite musculoskeletal pain
  publication-title: PAIN
  doi: 10.1097/j.pain.0000000000002052
  contributor:
    fullname: Liu
– volume: 6
  start-page: 78
  year: 2010
  ident: R86-20230213
  article-title: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
  publication-title: Metabolomics
  doi: 10.1007/s11306-009-0178-y
  contributor:
    fullname: Sugimoto
– volume: 26
  start-page: 445
  year: 2022
  ident: R36-20230213
  article-title: Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia
  publication-title: Eur J Pain
  doi: 10.1002/ejp.1871
  contributor:
    fullname: Hsu
– volume: 27
  start-page: 235
  year: 2013
  ident: R13-20230213
  article-title: Characteristics of pain assessed with visual analog scale and questionnaire in burning mouth syndrome patients: a pilot study
  publication-title: J Orofac Pain
  doi: 10.11607/jop.1038
  contributor:
    fullname: Braud
– volume: 2008
  start-page: 1301
  year: 2008
  ident: R98-20230213
  article-title: Burning mouth syndrome
  publication-title: BMJ Clin Evid
  contributor:
    fullname: Buchanan
– volume: 33
  start-page: 1631
  year: 2015
  ident: R67-20230213
  article-title: Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis
  publication-title: J Orthop Res
  doi: 10.1002/jor.22949
  contributor:
    fullname: Mickiewicz
– volume: 471
  start-page: 158
  year: 2017
  ident: R80-20230213
  article-title: Diagnostic potential of inflammatory biomarkers in early childhood caries—a case control study
  publication-title: Clin Chim Acta
  doi: 10.1016/j.cca.2017.05.037
  contributor:
    fullname: Sharma
– volume: 15
  start-page: 73
  year: 1998
  ident: R18-20230213
  article-title: Burning mouth in Parkinson's Disease sufferers
  publication-title: Gerodontology
  doi: 10.1111/j.1741-2358.1998.00073.x
  contributor:
    fullname: Clifford
– volume: 33
  start-page: 932
  year: 2013
  ident: R20-20230213
  article-title: The role of tyrosine metabolism in the pathogenesis of chronic migraine
  publication-title: Cephalalgia
  doi: 10.1177/0333102413480755
  contributor:
    fullname: D'Andrea
– volume: 95
  start-page: 1381
  year: 2016
  ident: R47-20230213
  article-title: Prediction of periodontal inflammation via metabolic profiling of saliva
  publication-title: J Dent Res
  doi: 10.1177/0022034516661142
  contributor:
    fullname: Kuboniwa
– volume: 33
  start-page: 641
  year: 1988
  ident: R41-20230213
  article-title: The assay of glandular kallikrein and prekallikrein in human mixed saliva
  publication-title: Arch Oral Biol
  doi: 10.1016/0003-9969(88)90117-3
  contributor:
    fullname: Jenzano
– volume: 104
  start-page: 471
  year: 2003
  ident: R93-20230213
  article-title: Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects
  publication-title: PAIN
  doi: 10.1016/S0304-3959(03)00067-8
  contributor:
    fullname: Wolf
– volume: 155
  start-page: 190
  year: 2014
  ident: R65-20230213
  article-title: 1H-NMR metabolic profiling of cerebrospinal fluid in patients with complex regional pain syndrome–related dystonia
  publication-title: PAIN
  doi: 10.1016/j.pain.2013.10.005
  contributor:
    fullname: Meissner
– volume: 16
  start-page: 365
  year: 2010
  ident: R11-20230213
  article-title: Neuropeptides in saliva of subjects with burning mouth syndrome: a pilot study
  publication-title: Oral Dis
  doi: 10.1111/j.1601-0825.2009.01648.x
  contributor:
    fullname: Borelli
– volume: 9
  start-page: 43
  year: 2008
  ident: R85-20230213
  article-title: Burning mouth syndrome responsive to pramipexol
  publication-title: J Headache Pain
  doi: 10.1007/s10194-008-0003-4
  contributor:
    fullname: Stuginski-Barbosa
– volume: 10
  start-page: 392
  year: 2021
  ident: R17-20230213
  article-title: Proteomics-based identification of salivary changes in patients with burning mouth syndrome
  publication-title: Biology (Basel)
  contributor:
    fullname: Castillo-Felipe
– volume: 24
  start-page: 827
  year: 2016
  ident: R99-20230213
  article-title: Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2015.12.004
  contributor:
    fullname: Zhang
– volume: 18
  start-page: 613
  year: 2012
  ident: R45-20230213
  article-title: Salivary cortisol, 17β-estradiol, progesterone, dehydroepiandrosterone, and α-amylase in patients with burning mouth syndrome
  publication-title: Oral Dis
  doi: 10.1111/j.1601-0825.2012.01937.x
  contributor:
    fullname: Kim
– volume: 105
  start-page: 467
  year: 2003
  ident: R100-20230213
  article-title: Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells
  publication-title: PAIN
  doi: 10.1016/S0304-3959(03)00261-6
  contributor:
    fullname: Zuo
– volume: 76
  start-page: 205
  year: 2015
  ident: R75-20230213
  article-title: Comparison of saliva interleukin-2 concentration to the condition of gums in children with acute lymphoblastic leukaemia during anti-tumour treatment
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-015-2750-7
  contributor:
    fullname: Pels
– volume: 37
  start-page: 120
  year: 2017
  ident: R70-20230213
  article-title: Comparison of salivary cortisol and α-amylase levels and psychological profiles in patients with burning mouth syndrome
  publication-title: Spec Care Dentist
  doi: 10.1111/scd.12214
  contributor:
    fullname: Nosratzehi
– volume: 1862
  start-page: 2124
  year: 2018
  ident: R88-20230213
  article-title: Plasma N-glycome composition associates with chronic low back pain
  publication-title: Biochim Biophys Acta Gen Subj
  doi: 10.1016/j.bbagen.2018.07.003
  contributor:
    fullname: Trbojević-Akmačić
– volume: 15
  start-page: 54
  year: 2019
  ident: R59-20230213
  article-title: The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
  publication-title: Metabolomics
  doi: 10.1007/s11306-019-1513-6
  contributor:
    fullname: Malatji
– volume: 17
  start-page: 17448069211041853
  year: 2021
  ident: R49-20230213
  article-title: Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: an exploratory metabolomics study
  publication-title: Mol Pain
  doi: 10.1177/17448069211041853
  contributor:
    fullname: Labus
– volume: 22
  start-page: 250
  year: 2015
  ident: R83-20230213
  article-title: The association of openness personality trait with stress-related salivary biomarkers in burning mouth syndrome
  publication-title: Neuroimmunomodulation
  doi: 10.1159/000367714
  contributor:
    fullname: de Souza
– volume: 79
  start-page: 205
  year: 2020
  ident: R14-20230213
  article-title: Sex matters: a focus on the impact of biological sex on metabolomic profiles and dietary interventions
  publication-title: Proc Nutr Soc
  doi: 10.1017/S002966511900106X
  contributor:
    fullname: Brennan
– volume: 46
  start-page: 37
  year: 2013
  ident: R26-20230213
  article-title: Purine metabolites in fibromyalgia syndrome
  publication-title: Clin Biochem
  doi: 10.1016/j.clinbiochem.2012.09.009
  contributor:
    fullname: Fais
– volume: 49
  start-page: 515
  year: 2004
  ident: R35-20230213
  article-title: Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbances
  publication-title: Arch Oral Biol
  doi: 10.1016/j.archoralbio.2004.01.012
  contributor:
    fullname: Hershkovich
– volume: 90
  start-page: 257
  year: 2001
  ident: R40-20230213
  article-title: Role of the dopaminergic system in chronic pain—a fluorodopa-PET study
  publication-title: PAIN
  doi: 10.1016/S0304-3959(00)00409-7
  contributor:
    fullname: JaÈaÈskelaÈinen
– volume: 54
  start-page: 159
  year: 1993
  ident: R1-20230213
  article-title: Tyramine conjugation deficit in patients with chronic idiopathic temporomandibular joint and orofacial pain
  publication-title: PAIN
  doi: 10.1016/0304-3959(93)90204-3
  contributor:
    fullname: Aghabeigi
SSID ssj0002229
Score 2.4884167
Snippet The pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic or...
ABSTRACTThe pathophysiology of primary burning mouth syndrome (BMS) remains controversial. Targeted analyses or "omics" approach of saliva provide diagnostic...
SourceID hal
proquest
crossref
pubmed
wolterskluwer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage e144
SubjectTerms Burning Mouth Syndrome
Case-Control Studies
Chronic Pain - metabolism
Cytokines - metabolism
Dermatology
Female
Hormones
Human health and pathology
Humans
Life Sciences
Metabolome
Pilot Projects
Saliva - chemistry
Title Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study
URI http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00006396-202303000-00023
https://www.ncbi.nlm.nih.gov/pubmed/35916738
https://search.proquest.com/docview/2697366470
https://hal.inrae.fr/hal-03886871
Volume 164
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1tb9MwELa6TpqGEOKd8iaD-Fa55KW1E75VE6hiFCHYxL5FseNo3dqkWlvQ-AH8Dn4qd7GdZBuTgH6IKid129yTu-eSu8eEvIJkLZNC-CwfjiBB0X7IJOTNLOTZSHkqUnmKN_SnH_nkcPj-aHTU6fxqVS1t1nKgfvyxr-R_rApjYFfskv0Hy9aTwgC8B_vCFiwM27-y8ZcUH-ScneM60GDMeblACZCsamtb9dP-6niWmyUAziEYIp-0B-LKGI2oqu1wg9Nb3SRZ4Kp6tZSB6YYGP-t6MvsKAh9zJe6NPK1luJ_SGeIpGi9QgiFDvNX3GqYlUNRN_ZS_dFVGVe1If5LKAnzPzO4_ncmmWgjChWki0WnB9ubpJtPtSeeOg1uJf3sbIwibOq6BNq43EgHj3HQf177ZSJxbEIYtT6t9oxt5JQQYaeGTwRL-rlGntC8gamH7E3D-losKGeEISLIwKjOX1Lfdri2yjVKLwy7ZHu9__rpfR3tcD93VDcbi9TXfu0t23EwXCNDWMZbfXs1tbpCb30ssl1idVt0SLc5zcJvcsskKHRvk3SEdXdwlO1NbjnGP_HQApA0AaQ1AmtIKgDBCHQBpA0AcdgCkCEBqAUgrAFIHwDcwTwt-tA0_WsHvPjl89_Zgb8Lswh5MAR0PGXivlANPVDrMNfDjPBplOQRdLwtUBjmEVrGKpIxRGiqIA-kNZSRiGekgBZcDtOsB6RZloR8R6keQ4WgBniaDXFeomGsFcUkDz5Yi07xHPHe2k6XRb0lc3cVJgrZKLtuqR16CVeqjUX99Mv6Q4BhKJ_FI-N_8HnnhjJaAQ8anbGmhy80qCXgsQs6HwuuRh8aa9VwOAz3CLpg3MU3P1U-BlIEzvEIg_BrVhyB8fO1MT8huczU9Jd312UY_A5q8ls8tUn8Ds4G-bw
link.rule.ids 230,314,780,784,885,27924,27925
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Salivary+metabolome+indicates+a+shift+in+tyrosine+metabolism+in+patients+with+burning+mouth+syndrome%3A+a+prospective+case-control+study&rft.jtitle=Pain+%28Amsterdam%29&rft.au=Moreau%2C+Charlotte&rft.au=El+Habnouni%2C+Chakib&rft.au=Lecron%2C+Jean-Claude&rft.au=Morel%2C+Franck&rft.date=2023-03-01&rft.eissn=1872-6623&rft.volume=164&rft.issue=3&rft.spage=e144&rft_id=info:doi/10.1097%2Fj.pain.0000000000002733&rft_id=info%3Apmid%2F35916738&rft.externalDocID=35916738
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3959&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3959&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3959&client=summon