A comment on two-locus epistatic interaction models for genome-wide association studies

• Published in: Journal of bioinformatics and computational biology Vol. 13; no. 6; p. 1571004
• Main Authors: Sohn, Kyung-Ah, Wee, Kyubum
• Format: Journal Article
• Language: English
• Published: Singapore 01.12.2015
• Subjects: Epistasis, Genetic; Genetic Predisposition to Disease; Genome-Wide Association Study - methods; Humans; Models, Genetic; Penetrance; Polymorphism, Single Nucleotide; GWAS; epistasis; disease models; simulation study

Detection of epistatic interactions in genome-wide association studies is a computationally hard problem. Many detection algorithms have been proposed and will continue to be. Most of those algorithms measure their predictive power by running on simulated data many times under various disease models...