The JAK-STAT Signaling Pathway: Input and Output Integration

• Published in: Journal of Immunology Vol. 178; no. 5; pp. 2623 - 2629
• Main Author: Murray, Peter J
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.03.2007
• Subjects: Animals; Gene Expression Regulation - genetics; Gene Expression Regulation - immunology; Humans; Janus Kinase 1 - genetics; Janus Kinase 1 - immunology; Receptors, Interleukin-10 - genetics; Receptors, Interleukin-10 - immunology; Receptors, Interleukin-6 - genetics; Receptors, Interleukin-6 - immunology; Signal Transduction - genetics; Signal Transduction - immunology; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - immunology; Transcriptional Activation

Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal transduction cascades. Almost 40 cytokine receptors signal through combinations of four JAK and seven STAT family members, suggesting commonality across the JAK-STAT signaling system. De...