Doxycycline serum protein binding in pigs reveals a relatively high free fraction

• Published in: Journal of veterinary pharmacology and therapeutics Vol. 46; no. 2; pp. 112 - 118
• Main Authors: Portugal, Felipe Ramon, Lacroix, Marlène Z., Roques, Béatrice B., Gayrard, Véronique, Toutain, Pierre‐Louis, Bousquet‐Mélou, Alain
• Format: Journal Article
• Language: English
• Published: England Wiley-Blackwell 01.03.2023
• Subjects: Animals; Anti-Bacterial Agents; antibiotic resistance; Blood Proteins; dialysis; Doxycycline; Life Sciences; pharmacology; pigs; PK/PD cut‐off; plasma protein binding; Protein Binding; Swine; therapeutics; pigs; plasma protein binding; doxycycline; PK/PD cut-off

Doxycycline is an antibiotic widely used in pig farming. As with all antibiotics, only the free concentrations are considered to be bacteriologically active. Historically, the free fraction (fu) in pig plasma has been estimated at 7%, which, given the effective dosage regime used in pigs, leads to f...