Some effects of dimethyl sulphoxide (DMSO) on the frog neuromuscular junction
Summary 1 Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg2+ on the frog sartorius nerve‐muscle preparation. 2 The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 mm or...
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Published in | British journal of pharmacology Vol. 49; no. 4; pp. 651 - 657 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.1973
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Subjects | |
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Abstract | Summary
1
Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg2+ on the frog sartorius nerve‐muscle preparation.
2
The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 mm or greater.
3
Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 mm or greater, but the increase in amplitude was generally less than in the case of the e.p.p.
4
The resting muscle membrane potential was significantly depolarized by DMSO at 70 mm or greater concentrations, both at the endplate and remote from an endplate.
5
The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle. |
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AbstractList | 1. Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)-tubocurarine or Mg(2+) on the frog sartorius nerve-muscle preparation.2. The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 mM or greater.3. Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 mM or greater, but the increase in amplitude was generally less than in the case of the e.p.p.4. The resting muscle membrane potential was significantly depolarized by DMSO at 70 mM or greater concentrations, both at the endplate and remote from an endplate.5. The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle. 1. Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)-tubocurarine or Mg 2+ on the frog sartorius nerve-muscle preparation. 2. The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 m M or greater. 3. Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 m M or greater, but the increase in amplitude was generally less than in the case of the e.p.p. 4. The resting muscle membrane potential was significantly depolarized by DMSO at 70 m M or greater concentrations, both at the endplate and remote from an endplate. 5. The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle. Summary Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg 2+ on the frog sartorius nerve‐muscle preparation. The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 m m or greater. Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 m m or greater, but the increase in amplitude was generally less than in the case of the e.p.p. The resting muscle membrane potential was significantly depolarized by DMSO at 70 m m or greater concentrations, both at the endplate and remote from an endplate. The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle. Summary 1 Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg2+ on the frog sartorius nerve‐muscle preparation. 2 The amplitude and duration of the endplate potential (e.p.p.) were increased by DMSO at concentrations of 70 mm or greater. 3 Miniature endplate potentials were raised in frequency, prolonged in duration and increased in amplitude by DMSO at concentrations of 141 mm or greater, but the increase in amplitude was generally less than in the case of the e.p.p. 4 The resting muscle membrane potential was significantly depolarized by DMSO at 70 mm or greater concentrations, both at the endplate and remote from an endplate. 5 The reversal of neurmuscular blockade by DMSO can be explained in terms of its previously reported ability to inhibit cholinesterase activity, together with the depolarizing action on muscle. |
Author | JAGGARD, PAMELA J. EVANS, M. H. |
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Cites_doi | 10.1113/jphysiol.1951.sp004675 10.1111/j.1749-6632.1967.tb34870.x 10.1111/j.2042-7158.1972.tb09022.x 10.1007/BF02476090 10.1111/j.1749-6632.1967.tb34885.x 10.1111/j.1749-6632.1967.tb34871.x 10.1111/j.1749-6632.1967.tb34896.x 10.3181/00379727-122-31063 |
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References | 1972; 24 1972; 10 1967; 141 1966; 122 1951; 115 e_1_2_1_7_1 e_1_2_1_8_1 e_1_2_1_5_1 e_1_2_1_6_1 e_1_2_1_3_1 e_1_2_1_4_1 e_1_2_1_2_1 e_1_2_1_9_1 |
References_xml | – volume: 115 start-page: 320 year: 1951 end-page: 370 article-title: An analysis of the end‐plate potential recorded with an intra‐cellular electrode publication-title: J. Physiol., Lond. – volume: 141 start-page: 310 year: 1967 end-page: 325 article-title: Procoagulant and nerve‐blocking effects of DMSO publication-title: Ann. N. Y. Acad. Sci. – volume: 122 start-page: 103 year: 1966 end-page: 107 article-title: Effect of dimethylsulphoxide on isolated‐innervated skeletal, smooth, and cardiac muscle publication-title: Proc. Soc. exp. Biol. – volume: 141 start-page: 96 year: 1967 end-page: 109 article-title: The single‐ and repeated‐dose toxicity of dimethyl sulphoxide publication-title: Ann. N. Y. Acad. Sci. – volume: 141 start-page: 110 year: 1967 end-page: 125 article-title: Limits of toxic and teratogenic tolerance of dimethyl sulphoxide publication-title: Ann. N.Y. Acad. Sci. – volume: 141 start-page: 242 year: 1967 end-page: 247 article-title: The effects of dimethyl sulphoxide on nerve conduction publication-title: Ann. N. Y. Acad. Sci. – volume: 24 start-page: 417 year: 1972 end-page: 419 article-title: Some actions of dimethylsulphoxide at the neuromuscular junction publication-title: J. Pharm. Pharmac. – volume: 10 start-page: 697 year: 1972 end-page: 700 article-title: A window‐type pulse‐height discriminator with limit monitoring publication-title: Med. & Biol. Eng. – ident: e_1_2_1_4_1 doi: 10.1113/jphysiol.1951.sp004675 – ident: e_1_2_1_9_1 doi: 10.1111/j.1749-6632.1967.tb34870.x – ident: e_1_2_1_5_1 doi: 10.1111/j.2042-7158.1972.tb09022.x – ident: e_1_2_1_6_1 doi: 10.1007/BF02476090 – ident: e_1_2_1_7_1 doi: 10.1111/j.1749-6632.1967.tb34885.x – ident: e_1_2_1_2_1 doi: 10.1111/j.1749-6632.1967.tb34871.x – ident: e_1_2_1_3_1 doi: 10.1111/j.1749-6632.1967.tb34896.x – ident: e_1_2_1_8_1 doi: 10.3181/00379727-122-31063 |
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Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg2+ on the frog sartorius... 1. Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)-tubocurarine or Mg(2+) on the frog sartorius... Summary Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)‐tubocurarine or Mg 2+ on the frog sartorius... 1. Dimethyl sulphoxide (DMSO) partially reversed neuromuscular blockade brought about by the action of (+)-tubocurarine or Mg 2+ on the frog sartorius... |
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SubjectTerms | Animals Anura Dimethyl Sulfoxide - pharmacology Dose-Response Relationship, Drug Drug Mechanisms In Vitro Techniques Magnesium - antagonists & inhibitors Membrane Potentials - drug effects Muscles - drug effects Neuromuscular Junction - drug effects Rana temporaria Time Factors Tubocurarine - antagonists & inhibitors |
Title | Some effects of dimethyl sulphoxide (DMSO) on the frog neuromuscular junction |
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