Effects of metabolic genotypes on intermediary biomarkers in subjects exposed to PAHS: results from the EXPAH study

• Published in: Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis Vol. 620; no. 1-2; pp. 7 - 15
• Main Authors: Garte, Seymour, Taioli, Emanuela, Raimondi, Sara, Paracchini, Valentina, Binkova, Blanka, Sram, Radim J, Kalina, Ivan, Popov, Todor A, Singh, Rajinder, Farmer, Peter B
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2007
• Subjects: Air Pollutants - toxicity; Aryl Hydrocarbon Hydroxylases - genetics; Benzo(a)pyrene - toxicity; Biomarkers; Carcinogens, Environmental - toxicity; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1B1; DNA Adducts - analysis; DNA Damage; Environmental Monitoring; Genotype; Glutathione S-Transferase pi - genetics; Glutathione Transferase - genetics; Humans; Polycyclic Aromatic Hydrocarbons - toxicity

Data from the EXPAH project on PAH exposure and intermediary biomarkers were analyzed with respect to individual genotypes at seven metabolic gene loci. The GSTM1 null allele was associated with significantly higher levels of two biomarkers, malondialdehyde-2'-deoxyguanosine and benzo[a]pyrene...