Rhythmic cilia changes support SCN neuron coherence in circadian clock

• Published in: Science (American Association for the Advancement of Science) Vol. 380; no. 6648; pp. 972 - 979
• Main Authors: Tu, Hai-Qing, Li, Sen, Xu, Yu-Ling, Zhang, Yu-Cheng, Li, Pei-Yao, Liang, Li-Yun, Song, Guang-Ping, Jian, Xiao-Xiao, Wu, Min, Song, Zeng-Qing, Li, Ting-Ting, Hu, Huai-Bin, Yuan, Jin-Feng, Shen, Xiao-Lin, Li, Jia-Ning, Han, Qiu-Ying, Wang, Kai, Zhang, Tao, Zhou, Tao, Li, Ai-Ling, Zhang, Xue-Min, Li, Hui-Yan
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 02.06.2023
• Subjects: Animals; Biological clocks; Cilia; Cilia - metabolism; Cilia - physiology; Circadian Clocks - genetics; Circadian Rhythm - physiology; Circadian rhythms; Gene expression; Gene Expression Regulation; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Jet lag; Mice; Mice, Transgenic; Neurons; Signal Transduction; Signaling; Suprachiasmatic nucleus; Suprachiasmatic Nucleus Neurons - physiology

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia...